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The de novo design of molecular structures using deep learning generative models introduces an encouraging solution to drug discovery in the face of the continuously increased cost of new drug development. From the generation of original…

生物大分子 · 定量生物学 2021-02-08 Yuemin Bian , Xiang-Qun Xie

We discuss new developments of interstellar chemistry, with particular emphasis on the carbon chemistry. We confirm that carbon chains and cycles are ubiquitous in the ISM and closely chemically related to ea ch other, and to carbon.…

天体物理学 · 物理学 2007-05-23 Maryvonne Gerin , David Fosse , Evelyne Roueff

The combination of modern scientific computing with electronic structure theory can lead to an unprecedented amount of data amenable to intelligent data analysis for the identification of meaningful, novel, and predictive structure-property…

Astrochemical modelling of the interstellar medium typically makes use of complex computational codes with parameters whose values can be varied. It is not always clear what the exact nature of the relationship is between these input…

星系天体物理 · 物理学 2023-09-14 Johannes Heyl , Joshua Butterworth , Serena Viti

Recent applications of machine learning and statistical inference provide case studies demonstrating how such approaches can accelerate the discovery process in physical chemistry and related fields. Examples discussed in this review…

化学物理 · 物理学 2017-06-20 Ryan B. Jadrich , Beth A. Lindquist , Thomas M. Truskett

The construction of viable and physically-realistic interstellar dust models is only possible if the constraints imposed by laboratory data on interstellar dust analogue materials are respected and used within a meaningful theoretical…

星系天体物理 · 物理学 2015-11-26 Ant Jones

Chemical composition of a molecular cloud is highly sensitive to the physical properties of the cloud. In order to obtain the chemical composition around a star forming region, we carry out a two dimensional hydrodynamical simulation of the…

星系天体物理 · 物理学 2013-06-04 Ankan Das , Liton Majumdar , Sandip K. Chakrabarti , Sonali Chakrabarti

In studies of the interstellar medium in galaxies, radiative transfer models of molecular emission are useful for relating molecular line observations back to the physical conditions of the gas they trace. However, doing this requires…

星系天体物理 · 物理学 2019-10-02 Damien de Mijolla , Serena Viti , Jonathan Holdship , Ioanna Manolopoulou , Jeremy Yates

The study of the chemical composition of the interstellar medium (ISM) requires a strong synergy between laboratory astrophysics, modeling, and observations. In particular, astrochemical models have been developed for decades now and…

星系天体物理 · 物理学 2024-07-24 V. Wakelam , P. Gratier , J. -C. Loison , K. M. Hickson , J. Penguen , A. Mechineau

Machine learning has been widely applied to clearly defined problems of astronomy and astrophysics. However, deep learning and its conceptual differences to classical machine learning have been largely overlooked in these fields. The broad…

天体物理仪器与方法 · 物理学 2024-10-15 Nima Sedaghat , Martino Romaniello , Jonathan E. Carrick , François-Xavier Pineau

Discovery of the molecular candidates for applications in drug targets, biomolecular systems, catalysts, photovoltaics, organic electronics, and batteries, necessitates development of machine learning algorithms capable of rapid exploration…

机器学习 · 计算机科学 2023-12-12 Ayana Ghosh , Sergei V. Kalinin , Maxim A. Ziatdinov

The size of chemical compound space is too large to be probed exhaustively. This leads high-throughput protocols to drastically subsample and results in sparse and non-uniform datasets. Rather than arbitrarily selecting compounds, we…

软凝聚态物质 · 物理学 2019-09-11 Christian Hoffmann , Roberto Menichetti , Kiran H. Kanekal , Tristan Bereau

A novel approach is presented for the solution of instantaneous chemical equilibrium problems. The chemical equilibrium can be considered, due to its intrinsically local character, as a mapping of the three-dimensional parameter space…

天体物理学 · 物理学 2009-11-11 A. Asensio Ramos , H. Socas-Navarro

While the uptake of data-driven approaches for materials science and chemistry is at an exciting, early stage, to realise the true potential of machine learning models for successful scientific discovery, they must have qualities beyond…

材料科学 · 物理学 2022-06-28 Felipe Oviedo , Juan Lavista Ferres , Tonio Buonassisi , Keith Butler

In recent years, conventional chemistry techniques have faced significant challenges due to their inherent limitations, struggling to cope with the increasing complexity and volume of data generated in contemporary research endeavors.…

Machine learning techniques have found their way into computational chemistry as indispensable tools to accelerate atomistic simulations and materials design. In addition, machine learning approaches hold the potential to boost the…

化学物理 · 物理学 2025-10-03 Johannes Voss

The determination of chemical abundances in star-forming galaxies and the study of their evolution on cosmological timescales are powerful tools for understanding galaxy formation and evolution. This contribution presents the latest results…

天体物理学 · 物理学 2007-05-23 Thierry Contini

The detailed analysis of molecular structures and properties holds great potential for drug development discovery through machine learning. Developing an emergent property in the model to understand molecules would broaden the horizons for…

Integrative modeling of macromolecular assemblies allows for structural characterization of large assemblies that are recalcitrant to direct experimental observation. A Bayesian inference approach facilitates combining data from…

生物大分子 · 定量生物学 2026-01-13 Shreyas Arvindekar , Kartik Majila , Shruthi Viswanath

We investigate the extent to which supervised machine learning techniques can distinguish between neutron-star matter models using macroscopic and oscillation-related quantities derived from theoretical stellar configurations. Four…

高能天体物理现象 · 物理学 2026-05-26 Wasif Husain