相关论文: AxonEM Dataset: 3D Axon Instance Segmentation of B…
Atom segmentation and localization, noise reduction and deblurring of atomic-resolution scanning transmission electron microscopy (STEM) images with high precision and robustness is a challenging task. Although several conventional…
Discovering the 3D atomic structure of molecules such as proteins and viruses is a fundamental research problem in biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising vision-based technique for structure estimation which…
Cryo-electron microscopy (cryo-EM) has become a tool of fundamental importance in structural biology, helping us understand the basic building blocks of life. The algorithmic challenge of cryo-EM is to jointly estimate the unknown 3D poses…
A connectivity graph of neurons at the resolution of single synapses provides scientists with a tool for understanding the nervous system in health and disease. Recent advances in automatic image segmentation and synapse prediction in…
Accurate instance-level segmentation of organelles in electron microscopy (EM) is critical for quantitative analysis of subcellular morphology and inter-organelle interactions. However, current benchmarks, based on small, curated datasets,…
Analyzing and reconstructing visual stimuli from brain signals effectively advances the understanding of human visual system. However, the EEG signals are complex and contain significant noise. This leads to substantial limitations in…
Quantifying axon and myelin properties (e.g., axon diameter, myelin thickness, g-ratio) in histology images can provide useful information about microstructural changes caused by neurodegenerative diseases. Automatic tissue segmentation is…
Reliable segmentation of anatomical tissues of human head is a major step in several clinical applications such as brain mapping, surgery planning and associated computational simulation studies. Segmentation is based on identifying…
We propose a new gradient-domain technique for processing registered EM image stacks to remove inter-image discontinuities while preserving intra-image detail. To this end, we process the image stack by first performing anisotropic…
This retrospective-prospective study evaluated whether a deep learning-based MRI reconstruction algorithm can preserve diagnostic quality in brain MRI scans accelerated up to fourfold, using both public and prospective clinical data. The…
A major limitation of two-dimensional scanning electron microscopy (SEM) in imaging porous membranes is its inability to resolve three-dimensional pore architecture and interconnectivity, which are critical factors governing membrane…
Resective surgery may be curative for drug-resistant focal epilepsy, but only 40% to 70% of patients achieve seizure freedom after surgery. Retrospective quantitative analysis could elucidate patterns in resected structures and patient…
A detailed analysis of ptychography for 3D phase reconstructions of thick specimens is performed. We introduce multi-focus ptychography, which incorporates a 4D-STEM defocus series to enhance the quality of 3D reconstructions along the beam…
Neuropathological analyses benefit from spatially precise volumetric reconstructions that enhance anatomical delineation and improve morphometric accuracy. Our prior work has shown the feasibility of reconstructing 3D brain volumes from 2D…
Excitable tissue is fundamental to brain function, yet its study is complicated by extreme morphological complexity and the physiological processes governing its dynamics. Consequently, detailed computational modeling of this tissue…
Reconstructing seeing images from fMRI recordings is an absorbing research area in neuroscience and provides a potential brain-reading technology. The challenge lies in that visual encoding in brain is highly complex and not fully revealed.…
Purpose: Neural network image reconstruction directly from measurement data is a relatively new field of research, that until now has been limited to producing small single-slice images (e.g., 1x128x128). This paper proposes a novel and…
The EMI (Extracellular-Membrane-Intracellular) model describes electrical activity in excitable tissue, where the extracellular and intracellular spaces and cellular membrane are explicitly represented. The model couples a system of partial…
Detecting synaptic clefts is a crucial step to investigate the biological function of synapses. The volume electron microscopy (EM) allows the identification of synaptic clefts by photoing EM images with high resolution and fine details.…
Cryogenic electron microscopy (cryo-EM) provides a unique opportunity to study the structural heterogeneity of biomolecules. Being able to explain this heterogeneity with atomic models would help our understanding of their functional…