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Techniques for preclinical intensity modulated radiation therapy are being developed to improve translation by replicating the clinical paradigm. This study presents the first treatment planning comparison between small animal IMRT…

To accurately verify the dose of intensity-modulated radiation therapy (IMRT), we have used a global optimization method to investigate a new dose-verification algorithm. In practical application of this quality assurance (QA) procedure,…

Temporally modulated pulsed radiotherapy (TMPRT) delivers conventional fraction doses of radiation using temporally separated pulses of low doses (<30 cGy) yielding fraction-effective dose rates of around 6.7 cGy/min with the goal to…

医学物理 · 物理学 2026-01-13 Christian Velten , Adam Bayliss , Jiayi Huang , Wolfgang A. Tomé

A central problem in the field of radiation therapy (RT) is how to optimally deliver dose to a patient in a way that fully accounts for anatomical position changes over time. As current RT is a static process, where beam intensities are…

医学物理 · 物理学 2019-09-04 Rodney D. Wiersma , Xinmin Liu

Intensity modulated radiotherapy (IMRT) is one of the most common modalities for treating cancer patients. One of the biggest challenges is precise treatment delivery that accounts for varying motion patterns originating from…

计算机视觉与模式识别 · 计算机科学 2023-03-15 Matej Gazda , Peter Drotar , Liset Vazquez Romaguera , Samuel Kadoury

Radiotherapy (RT) is a key component in the treatment of various cancers, including Acute Lymphocytic Leukemia (ALL) and Acute Myelogenous Leukemia (AML). Precise delineation of organs at risk (OARs) and target areas is essential for…

计算机视觉与模式识别 · 计算机科学 2023-11-14 Ricardo Coimbra Brioso , Damiano Dei , Ciro Franzese , Nicola Lambri , Daniele Loiacono , Pietro Mancosu , Marta Scorsetti

Objective: Intensity-modulated radiation therapy (IMRT) beam angle optimization (BAO) is a challenging combinatorial optimization problem that is NP-hard. In this study, we aim to develop a personalized BAO algorithm for IMRT that improves…

医学物理 · 物理学 2023-03-08 Peng Bao , Gong Wang , Ruijie Yang , Bin Dong

The total variation (TV) regularization has phenomenally boosted various variational models for image processing tasks. We propose to combine the backward diffusion process in the earlier literature of image enhancement with the TV…

图像与视频处理 · 电气工程与系统科学 2023-06-14 Congpei An , Hao-Ning Wu , Xiaoming Yuan

Today, intensity-modulated radiation therapy (IMRT) is one of the methods used to treat brain tumors. In conventional treatment planning methods, after identifying planning target volume (PTV), and organs at risk (OARs), and determining the…

定量方法 · 定量生物学 2023-05-15 Mobina Naeemi , Mohamad Reza Esmaeili , Iraj Abedi

Total variation (TV) is a powerful regularization method that has been widely applied in different imaging applications, but is difficult to apply to diffuse optical tomography (DOT) image reconstruction (inverse problem) due to complex and…

计算机视觉与模式识别 · 计算机科学 2019-04-08 Wenqi Lu , Jinming Duan , David Orive-Miguel , Lionel Herve , Iain B Styles

We present a novel application of Tensor Network methods in cancer treatment as a potential tool to solve the dose optimization problem in radiotherapy. In particular, the Intensity-Modulated Radiation Therapy (IMRT) technique - that allows…

医学物理 · 物理学 2021-08-11 Samuele Cavinato , Timo Felser , Marco Fusella , Marta Paiusco , Simone Montangero

Radiation therapy is considered to be one of important treatment protocols for cancers. Radiation therapy employs several beams of ionizing radiation to kill cancer tumors, but such irradiation also causes damage to normal tissues.…

最优化与控制 · 数学 2016-12-06 Shogo Kishimoto , Makoto Yamashita

Purpose: To evaluate automated multicriteria optimization (MCO)-- designed for intensity modulated radiation therapy (IMRT), but invoked with limited segmentation -- to efficiently produce high quality 3D conformal treatment (3D-CRT) plans.…

医学物理 · 物理学 2014-02-03 Fazal Khan , David Craft

Non-coplanar Intensity-Modulated Radiation Therapy (IMRT) goes a step further by orienting the gantry carrying the radiation beam and the patient couch in a non-coplanar manner to accurately target the cancer region and better avoid…

医学物理 · 物理学 2023-05-16 Fang Guo , Franklin Okoli , Ulrike Schick , Dimitris Visvikis , Antoine Valeri , Julien Bert

Purpose: To investigate the impact of delivery techniques and planning parameters on interplay effect in lung SBRT. Methods: A dynamic virtual patient model containing normal structures and a tumor with adjustable sizes, locations, and 3D…

This work considers using reduced basis techniques in connection to (smoothened) total variation regularization in electrical impedance tomography, but analogous ideas can also be used for other inverse elliptic boundary value problems. It…

数值分析 · 数学 2026-02-18 A. Hannukainen , N. Hyvönen , V. Toresen

Conventional planning objectives in optimization of intensity-modulated radiotherapy treatment (IMRT) plans are designed to minimize the violation of dose-volume histogram (DVH) thresholds using penalty functions. Although successful in…

医学物理 · 物理学 2023-07-19 Lovisa Engberg , Kjell Eriksson , Anders Forsgren , Björn Hårdemark

A split feasibility formulation for the inverse problem of intensity-modulated radiation therapy (IMRT) treatment planning with dose-volume constraints (DVCs) included in the planning algorithm is presented. It involves a new type of…

医学物理 · 物理学 2017-04-26 S. Penfold , R. Zalas , M. Casiraghi , M. Brooke , Y. Censor , R. Schulte

A new strategy for radiation therapy dosimetry planning (RTDP) used to reduce dose estimation errors due to respiratory motion in breast treatment was illustrated and evaluated in this study. On CT data set acquired for breast treatment,…

医学物理 · 物理学 2021-10-20 Mazen Moussallem , Pauline Harb , Hanane Rima , Zeina Al Kattar , Saad Ayoubi

Implicit Neural Representations (INRs) are a learning-based approach to accelerate Magnetic Resonance Imaging (MRI) acquisitions, particularly in scan-specific settings when only data from the under-sampled scan itself are available.…

图像与视频处理 · 电气工程与系统科学 2024-12-11 Yamin Arefeen , Brett Levac , Zach Stoebner , Jonathan Tamir
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