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Machine learning (ML) offers a collection of powerful approaches for detecting and modeling associations, often applied to data having a large number of features and/or complex associations. Currently, there are many tools to facilitate…

Risk prediction models are increasingly used in healthcare to aid in clinical decision making. In most clinical contexts, model calibration (i.e., assessing the reliability of risk estimates) is critical. Data available for model…

统计方法学 · 统计学 2024-05-01 Alex Carriero , Kim Luijken , Anne de Hond , Karel GM Moons , Ben van Calster , Maarten van Smeden

Bayesian models quantify uncertainty and facilitate optimal decision-making in downstream applications. For most models, however, practitioners are forced to use approximate inference techniques that lead to sub-optimal decisions due to…

机器学习 · 统计学 2019-09-12 Tomasz Kuśmierczyk , Joseph Sakaya , Arto Klami

As artificial intelligence systems move toward clinical deployment, ensuring reliable prediction behavior is fundamental for safety-critical decision-making tasks. One proposed safeguard is selective prediction, where models can defer…

机器学习 · 计算机科学 2026-05-25 L. Julián Lechuga López , Farah E. Shamout , Tim G. J. Rudner

Targeted therapies on the basis of genomic aberrations analysis of the tumor have shown promising results in cancer prognosis and treatment. Regardless of tumor type, trials that match patients to targeted therapies for their particular…

应用统计 · 统计学 2018-04-18 Yanxun Xu , Peter Mueller , Apostolia M Tsimberidou , Donald Berry

Modern neural networks have found to be miscalibrated in terms of confidence calibration, i.e., their predicted confidence scores do not reflect the observed accuracy or precision. Recent work has introduced methods for post-hoc confidence…

计算机视觉与模式识别 · 计算机科学 2021-09-22 Fabian Küppers , Jan Kronenberger , Jonas Schneider , Anselm Haselhoff

Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health…

Tuberculosis (TB) is a major global health challenge, and is compounded by co-morbidities such as HIV, diabetes, and anemia, which complicate treatment outcomes and contribute to heterogeneous patient responses. Traditional models of TB…

机器学习 · 计算机科学 2024-11-19 Ethan Wu , Caleb Ellington , Ben Lengerich , Eric P. Xing

Predictive uncertainty-a model's self awareness regarding its accuracy on an input-is key for both building robust models via training interventions and for test-time applications such as selective classification. We propose a novel…

机器学习 · 计算机科学 2024-01-04 Nishant Jain , Karthikeyan Shanmugam , Pradeep Shenoy

Identifying the parameters of a model and rating competitive models based on measured data has been among the most important but challenging topics in modern science and engineering, with great potential of application in structural system…

统计计算 · 统计学 2017-08-02 F. A. DiazDelaO , A. Garbuno-Inigo , S. K. Au , I. Yoshida

In the context of computer models, calibration is the process of estimating unknown simulator parameters from observational data. Calibration is variously referred to as model fitting, parameter estimation/inference, an inverse problem, and…

统计方法学 · 统计学 2023-10-16 Richard D. Wilkinson , Christopher W. Lanyon

Finding patient subgroups with similar characteristics is crucial for personalized decision-making in various disciplines such as healthcare and policy evaluation. While most existing approaches rely on unsupervised clustering methods,…

机器学习 · 统计学 2026-03-06 Luwei Wang , Nazir Lone , Sohan Seth

We address modelling and computational issues for multiple treatment effect inference under many potential confounders. Our main contribution is providing a trade-off between preventing the omission of relevant confounders, while not…

统计方法学 · 统计学 2025-02-04 Omiros Papaspiliopoulos , David Rossell , Miquel Torrens-i-Dinarès

In the last decade, the secondary use of large data from health systems, such as electronic health records, has demonstrated great promise in advancing biomedical discoveries and improving clinical decision making. However, there is an…

统计理论 · 数学 2021-03-25 Rui Duan , Yang Ning , Jiasheng Shi , Raymond J Carroll , Tianxi Cai , Yong Chen

It is argued that the Calibrated Bayesian (CB) approach to statistical inference capitalizes on the strength of Bayesian and frequentist approaches to statistical inference. In the CB approach, inferences under a particular model are…

统计方法学 · 统计学 2011-08-10 Roderick Little

This study explores the application of machine learning models, specifically a pretrained ResNet-50 model and a general SqueezeNet model, in diagnosing tuberculosis (TB) using chest X-ray images. TB, a persistent infectious disease…

计算机视觉与模式识别 · 计算机科学 2025-12-03 Daanish Hindustani , Sanober Hindustani , Preston Nguyen

We develop a new approach to solving classification problems, which is bases on the theory of coherent measures of risk and risk sharing ideas. The proposed approach aims at designing a risk-averse classifier. The new approach allows for…

机器学习 · 统计学 2018-07-24 Constantine Vitt , Darinka Dentcheva , Hui Xiong

Objectives: Metabolic Bariatric Surgery (MBS) is a critical intervention for patients living with obesity and related health issues. Accurate classification and prediction of patient outcomes are vital for optimizing treatment strategies.…

We study objective Bayesian inference for linear regression models with residual errors distributed according to the class of two-piece scale mixtures of normal distributions. These models allow for capturing departures from the usual…

应用统计 · 统计学 2016-05-09 F. J. Rubio , K. Yu

In prediction problems, it is common to model the data-generating process and then use a model-based procedure, such as a Bayesian predictive distribution, to quantify uncertainty about the next observation. However, if the posited model is…

统计方法学 · 统计学 2021-07-06 Pei-Shien Wu , Ryan Martin