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This paper studies a two-stage model of experimentation, where the researcher first samples representative units from an eligible pool, then assigns each sampled unit to treatment or control. To implement balanced sampling and assignment,…

计量经济学 · 经济学 2023-08-22 Max Cytrynbaum

In the integrative analyses of omics data, it is often of interest to extract data representation from one data type that best reflect its relations with another data type. This task is traditionally fulfilled by linear methods such as…

应用统计 · 统计学 2021-03-30 Tianwei Yu

We seek to identify genes involved in Parkinson's Disease (PD) by combining information across different experiment types. Each experiment, taken individually, may contain too little information to distinguish some important genes from…

Various statistical tests have been developed for testing the equality of means in matched pairs with missing values. However, most existing methods are commonly based on certain distributional assumptions such as normality, 0-symmetry or…

统计理论 · 数学 2016-03-02 Lubna Amro , Markus Pauly

As the size of modern data sets exceeds the disk and memory capacities of a single computer, machine learning practitioners have resorted to parallel and distributed computing. Given that optimization is one of the pillars of machine…

机器学习 · 统计学 2019-12-10 Biyi Fang , Diego Klabjan

Urban structure detection is a basic task in urban geography. Clustering is a core technology to detect the patterns of urban spatial structure, urban functional region, and so on. In big data era, diverse urban sensing datasets recording…

社会与信息网络 · 计算机科学 2017-07-13 Xin Lin , Haifeng Li , Yan Zhang , Lei Gao , Ling Zhao , Min Deng

This paper proposes nonparametric two-sample tests for the direct comparison of the probabilities of a particular transition between states of a continuous time nonhomogeneous Markov process with a finite state space. The proposed tests are…

统计方法学 · 统计学 2020-02-24 Giorgos Bakoyannis

The continuing advances of omic technologies mean that it is now more tangible to measure the numerous features collectively reflecting the molecular properties of a sample. When multiple omic methods are used, statistical and computational…

基因组学 · 定量生物学 2023-08-14 Tim Downing , Nicos Angelopoulos

Many studies collect data that can be considered as a realization of a point process. Included are medical imaging data where photon counts are recorded by a gamma camera from patients being injected with a gamma emitting tracer. It is of…

统计方法学 · 统计学 2025-10-21 Jamshid Namdari , Robert T Krafty , Amita Manatunga

Training large language models (LLMs) from scratch can yield models with unique functionalities and strengths, but it is costly and often leads to redundant capabilities. A more cost-effective alternative is to fuse existing pre-trained…

This paper studies the problem of estimation from relative measurements in a graph, in which a vector indexed over the nodes has to be reconstructed from pairwise measurements of differences between its components associated to nodes…

系统与控制 · 计算机科学 2018-07-27 Chiara Ravazzi , Nelson P. K. Chan , Paolo Frasca

We consider a partially linear framework for modelling massive heterogeneous data. The major goal is to extract common features across all sub-populations while exploring heterogeneity of each sub-population. In particular, we propose an…

统计理论 · 数学 2016-01-26 Tianqi Zhao , Guang Cheng , Han Liu

Rapid technological advances have allowed for molecular profiling across multiple omics domains from a single sample for clinical decision making in many diseases, especially cancer. As tumor development and progression are dynamic…

统计方法学 · 统计学 2022-02-11 Dongyan Yan , Subharup Guha

In this paper, a novel diffusion estimation algorithm is proposed from a probabilistic perspective by combining diffusion strategy and the probabilistic least-mean-squares (PLMS) at all agents. The proposed method diffusion probabilistic…

信号处理 · 电气工程与系统科学 2019-08-27 Sihai Guan , Chun Meng , Bharat Biswal

To generate synthetic datasets, e.g., in domains such as healthcare, the literature proposes approaches of two main types: Probabilistic Graphical Models (PGMs) and Deep Learning models, such as LLMs. While PGMs produce synthetic data that…

数据库 · 计算机科学 2026-03-31 Antheas Kapenekakis , Bent Thomsen , Katja Hose , Michele Albano

This paper introduces a novel hybrid model combining Partial Differential Equations (PDEs) and Ordinary Differential Equations (ODEs) to simulate infectious disease dynamics across geographic regions. By leveraging the spatial detail of…

动力系统 · 数学 2025-11-18 Kristina Kehrer , Martin Weiser , Tim Conrad

Recently, the use of Polynomial Chaos Expansion (PCE) has been increasing to study the uncertainty in mathematical models for a wide range of applications and several extensions of the original PCE technique have been developed to deal with…

数值分析 · 数学 2014-06-23 Maria Navarro , Jeroen Witteveen , Joke Blom

Partial least squares (PLS) is a dimensionality reduction technique introduced in the field of chemometrics and successfully employed in many other areas. The PLS components are obtained by maximizing the covariance between linear…

统计方法学 · 统计学 2023-12-05 David del Val , José R. Berrendero , Alberto Suárez

In physics we often use very simple models to describe systems with many degrees of freedom, but it is not clear why or how this success can be transferred to the more complex biological context. We consider models for the joint…

神经元与认知 · 定量生物学 2024-12-06 Luisa Ramirez , William Bialek , Stephanie E. Palmer , David J. Schwab

In statistics, series of ordinary least squares problems (OLS) are used to study the linear correlation among sets of variables of interest; in many studies, the number of such variables is at least in the millions, and the corresponding…

计算工程、金融与科学 · 计算机科学 2015-04-30 Alvaro Frank , Diego Fabregat-Traver , Paolo Bientinesi