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Drug repositioning aims to identify potential new indications for existing drugs to reduce the time and financial costs associated with developing new drugs. Most existing deep learning-based drug repositioning methods predominantly utilize…

机器学习 · 计算机科学 2025-06-02 Renye Zhang , Mengyun Yang , Qichang Zhao , Jianxin Wang

Drug combinations offer therapeutic benefits but also carry the risk of adverse drug-drug interactions (DDIs), especially under complex molecular structures. Accurate DDI event prediction requires capturing fine-grained inter-drug…

机器学习 · 计算机科学 2025-10-27 Xuan Lin , Aocheng Ding , Tengfei Ma , Hua Liang , Zhe Quan

Large-scale Electronic Health Record (EHR) databases have become indispensable in supporting clinical decision-making through data-driven treatment recommendations. However, existing medication recommender methods often struggle with a user…

机器学习 · 计算机科学 2026-02-02 Arya Hadizadeh Moghaddam , Mohsen Nayebi Kerdabadi , Dongjie Wang , Mei Liu , Zijun Yao

Graph Neural Networks (GNNs) have substantially advanced the field of recommender systems. However, despite the creation of more than a thousand knowledge graphs (KGs) under the W3C standard RDF, their rich semantic information has not yet…

信息检索 · 计算机科学 2025-06-11 Michael Färber , David Lamprecht , Yuni Susanti

Despite extensive safety assessments of drugs prior to their introduction to the market, certain adverse drug reactions (ADRs) remain undetected. The primary objective of pharmacovigilance is to identify these ADRs (i.e., signals). In…

统计方法学 · 统计学 2024-04-23 Louis Dijkstra , Tania Schink , Ronja Foraita

The graph-based recommendation has achieved great success in recent years. However, most existing graph-based recommendations focus on capturing user preference based on positive edges/feedback, while ignoring negative edges/feedback (e.g.,…

信息检索 · 计算机科学 2024-05-27 Yiqing Wu , Ruobing Xie , Zhao Zhang , Xu Zhang , Fuzhen Zhuang , Leyu Lin , Zhanhui Kang , Yongjun Xu

Recent recommender system advancements have focused on developing sequence-based and graph-based approaches. Both approaches proved useful in modeling intricate relationships within behavioral data, leading to promising outcomes in…

信息检索 · 计算机科学 2024-03-18 Vladimir Baikalov , Evgeny Frolov

Click-through rate (CTR) prediction is an essential task in web applications such as online advertising and recommender systems, whose features are usually in multi-field form. The key of this task is to model feature interactions among…

信息检索 · 计算机科学 2020-07-27 Zekun Li , Zeyu Cui , Shu Wu , Xiaoyu Zhang , Liang Wang

Electronic Health Records (EHR) are high-dimensional data with implicit connections among thousands of medical concepts. These connections, for instance, the co-occurrence of diseases and lab-disease correlations can be informative when…

机器学习 · 计算机科学 2021-03-29 Weicheng Zhu , Narges Razavian

User and item attributes are essential side-information; their interactions (i.e., their co-occurrence in the sample data) can significantly enhance prediction accuracy in various recommender systems. We identify two different types of…

信息检索 · 计算机科学 2021-07-26 Yixin Su , Rui Zhang , Sarah Erfani , Junhao Gan

Medication recommendation is an essential task of AI for healthcare. Existing works focused on recommending drug combinations for patients with complex health conditions solely based on their electronic health records. Thus, they have the…

机器学习 · 计算机科学 2022-07-20 Chaoqi Yang , Cao Xiao , Fenglong Ma , Lucas Glass , Jimeng Sun

Recommender system research has oftentimes focused on approaches that operate on large-scale datasets containing millions of user interactions. However, many small businesses struggle to apply state-of-the-art models due to their very…

Drug-target interaction (DTI) prediction has become a foundational task in drug repositioning, polypharmacology, drug discovery, as well as drug resistance and side-effect prediction. DTI identification using machine learning is gaining…

Personalized drug response has received public awareness in recent years. How to combine gene test result and drug sensitivity records is regarded as essential in the real-world implementation. Research articles are good sources to train…

社会与信息网络 · 计算机科学 2019-06-20 Shiyin Wang

Incorporating Knowledge Graphs (KG) into recommeder system has attracted considerable attention. Recently, the technical trend of Knowledge-aware Recommendation (KGR) is to develop end-to-end models based on graph neural networks (GNNs).…

信息检索 · 计算机科学 2022-08-23 Ding Zou , Wei Wei , Ziyang Wang , Xian-Ling Mao , Feida Zhu , Rui Fang , Dangyang Chen

Sequential recommendation aims to model users' evolving interests from noisy and non-stationary interaction streams, where long-term preferences, short-term intents, and localized behavioral fluctuations may coexist across temporal scales.…

信息检索 · 计算机科学 2026-04-24 Peilin Liu , Zhiquan Ji , Gang Yan

Medication recommendations aim to generate safe and effective medication sets from health records. However, accurately recommending medications hinges on inferring a patient's latent clinical condition from sparse and noisy observations,…

信息检索 · 计算机科学 2026-03-20 Xiangxu Zhang , Xiao Zhou , Hongteng Xu , Jianxun Lian

Collaborative recommendation fundamentally involves learning high-quality user and item representations from interaction data. Recently, graph convolution networks (GCNs) have advanced the field by utilizing high-order connectivity patterns…

信息检索 · 计算机科学 2024-12-30 Jiajia Chen , Jiancan Wu , Jiawei Chen , Chongming Gao , Yong Li , Xiang Wang

Benefiting from the powerful expressive capability of graphs, graph-based approaches have achieved impressive performance in various biomedical applications. Most existing methods tend to define the adjacency matrix among samples manually…

机器学习 · 计算机科学 2021-07-02 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yao Zhao

With the development of social platforms, people are more and more inclined to combine into groups to participate in some activities, so group recommendation has gradually become a problem worthy of research. For group recommendation, an…

信息检索 · 计算机科学 2021-09-24 Bojie Wang , Yuheng Lu
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