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This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a control and hypoxia induced hypertensive mouse. We use local…

流体动力学 · 物理学 2019-10-02 Mitchel J. Colebank , M. Umar Qureshi , Mette S. Olufsen

Microcirculation of blood and oxygen transport play important roles in biological function of optic nerve and are directly affected by damages or pathologies. This work develops a multi-domain model for optic nerve, that includes important…

生物物理 · 物理学 2024-01-18 Zilong Song , Shixin Xu , Robert Eisenberg , Huaxiong Huang

Stochastic simulation is widely used to study complex systems composed of various interconnected subprocesses, such as input processes, routing and control logic, optimization routines, and data-driven decision modules. In practice, these…

统计计算 · 统计学 2026-02-19 Mohammadmahdi Ghasemloo , David J. Eckman , Yaxian Li

We report an ab-initio simulation of liquid Indium in a wide range of pressures and temperatures. We calculate equation of state, thermal expansion and compressibility coefficients. The structure of the system is analyzed by radial…

软凝聚态物质 · 物理学 2022-02-11 Yu. D. Fomin

The aim of this paper is to provide a mathematical model for spatial distribution of membrane electrical potential changes by fluorescence diffuse optical tomography. We derive the resolving power of the imaging method in the presence of…

数学物理 · 物理学 2013-07-09 Habib Ammari , Josselin Garnier , Laure Giovangigli

We propose a computational method to quantitatively evaluate the systematic uncertainties that arise from undetectable sources in biological measurements using live-cell imaging techniques. We then demonstrate this method in measuring…

定量方法 · 定量生物学 2019-07-09 Masaki Watabe , Satya N. V. Arjunan , Wei Xiang Chew , Kazunari Kaizu , Koichi Takahashi

Visual uncertainties such as occlusions, lack of texture, and noise present significant challenges in obtaining accurate kinematic models for safe robotic manipulation. We introduce a probabilistic real-time approach that leverages the…

机器人学 · 计算机科学 2025-11-04 Adrian Pfisterer , Xing Li , Vito Mengers , Oliver Brock

We provide an efficient method to approximate the covariance between decision variables and uncertain parameters in solutions to a general class of stochastic nonlinear complementarity problems. We also develop a sensitivity metric to…

最优化与控制 · 数学 2018-10-10 Sriram Sankaranarayanan , Felipe Feijoo , Sauleh Siddiqui

Understanding the mechanisms of interactions within cells, tissues, and organisms is crucial to driving developments across biology and medicine. Mathematical modeling is an essential tool for simulating biological systems and revealing…

分子网络 · 定量生物学 2024-08-13 Lingxia Qiao , Ali Khalilimeybodi , Nathaniel J Linden-Santangeli , Padmini Rangamani

In the context of industrially mass-manufactured products, quality management is based on physically inspecting a small sample from a large batch and reasoning about the batch's quality conformance. When complementing physical inspections…

应用统计 · 统计学 2024-02-22 Simon Cramer , Tobias Müller , Robert H. Schmitt

Understanding the mental state of other people is an important skill for intelligent agents and robots to operate within social environments. However, the mental processes involved in `mind-reading' are complex. One explanation of such…

计算机视觉与模式识别 · 计算机科学 2019-11-05 Jonathan Vitale , Mary-Anne Williams , Benjamin Johnston , Giuseppe Boccignone

In the framework of the estimation of safety margins in nuclear accident analysis, a quantitative assessment of the uncertainties tainting the results of computer simulations is essential. Accurate uncertainty propagation (estimation of…

应用统计 · 统计学 2019-01-01 Bertrand Iooss , Amandine Marrel

In many areas of engineering and sciences, decision rules and control strategies are usually designed based on nominal values of relevant system parameters. To ensure that a control strategy or decision rule will work properly when the…

概率论 · 数学 2020-06-16 Xinjia Chen

Simulations using machine learning (ML) models and mechanistic models are often run to inform decision-making processes. Uncertainty estimates of simulation results are critical to the decision-making process because simulation results of…

机器学习 · 计算机科学 2023-08-08 Babajide Kolade

In this article, we review the mathematical modeling for the vascular system.

组织与器官 · 定量生物学 2021-04-23 Ju Liu , Ingrid S. Lan , Alison L. Marsden

Computational cardiovascular models are promising tools for clinical decision support, particularly in complex conditions, such as intraoperative hypotension (IOH). IOH arises from different mechanisms, making treatment selection…

医学物理 · 物理学 2025-09-19 Jan-Niklas Thiel , Marko Zlicar , Ulrich Steinseifer , Borut Kirn , Michael Neidlin

A set of physics models and parameters pertaining to the simulation of proton energy deposition in matter are evaluated in the energy range up to approximately 65 MeV, based on their implementations in the Geant4 toolkit. The analysis…

计算物理 · 物理学 2016-11-17 Maria Grazia Pia , Marcia Begalli , Anton Lechner , Lina Quintieri , Paolo Saracco

Computational mechanisms for uncertainty management must support interactive and incremental problem formulation, inference, hypothesis testing, and decision making. However, most current uncertainty inference systems concentrate primarily…

人工智能 · 计算机科学 2013-04-10 Bruce D'Ambrosio

Assessing the validity of a real-world system with respect to given quality criteria is a common yet costly task in industrial applications due to the vast number of required real-world tests. Validating such systems by means of simulation…

机器学习 · 计算机科学 2024-09-06 David Reeb , Kanil Patel , Karim Barsim , Martin Schiegg , Sebastian Gerwinn

Effectively measuring and modeling the reliability of a trained model is essential to the real-world deployment of monocular depth estimation (MDE) models. However, the intrinsic ill-posedness and ordinal-sensitive nature of MDE pose major…

计算机视觉与模式识别 · 计算机科学 2023-07-20 Mochu Xiang , Jing Zhang , Nick Barnes , Yuchao Dai