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Disease subtype identification (clustering) is an important problem in biomedical research. Gene expression profiles are commonly utilized to infer disease subtypes, which often lead to biologically meaningful insights into disease. Despite…

统计方法学 · 统计学 2016-09-27 Jiehuan Sun , Joshua L. Warren , Hongyu Zhao

The usefulness of Bayesian models for density and cluster estimation is well established across multiple literatures. However, there is still a known tension between the use of simpler, more interpretable models and more flexible, complex…

统计方法学 · 统计学 2025-10-07 Henrique Bolfarine , Hedibert F. Lopes , Carlos M. Carvalho

We develop a factor analysis for mixed continuous and binary observed variables. To this end, we utilized a recently developed multivariate probability distribution for mixed-type random variables, the Gaussian-Grassmann distribution. In…

统计方法学 · 统计学 2025-12-12 Takashi Arai

The analysis of multivariate functional curves has the potential to yield important scientific discoveries in domains such as healthcare, medicine, economics and social sciences. However, it is common for real-world settings to present…

统计方法学 · 统计学 2024-07-23 Tui Nolan , Sylvia Richardson , Hélène Ruffieux

Consistent experiment data are crucial to adjust parameters of physics models and to determine best estimates of observables. However, often experiment data are not consistent due to unrecognized systematic errors. Standard methods of…

核理论 · 物理学 2018-03-05 Georg Schnabel

Rate variation among the sites of a molecular sequence is commonly found in applications of phylogenetic inference. Several approaches exist to account for this feature but they do not usually enable the investigator to pinpoint the sites…

定量方法 · 定量生物学 2013-05-23 Elisa Loza-Reyes , Merrilee Hurn , Tony Robinson

This paper develops a Bayesian graphical model for fusing disparate types of count data. The motivating application is the study of bacterial communities from diverse high dimensional features, in this case transcripts, collected from…

Structural transformation, the shift from agrarian economies to more diversified industrial and service-based systems, is a key driver of economic development. However, in low- and middle-income countries (LMICs), data scarcity and…

应用统计 · 统计学 2025-10-02 Ronald Katende

Modern cancer genomics datasets involve widely varying sizes and scales, measurement variables, and correlation structures. A fundamental analytical goal in these high-throughput studies is the development of general statistical techniques…

统计方法学 · 统计学 2022-04-12 Chiyu Gu , Veerabhadran Baladandayuthapani , Subharup Guha

This article introduces a nonparametric approach to spectral analysis of a high-dimensional multivariate nonstationary time series. The procedure is based on a novel frequency-domain factor model that provides a flexible yet parsimonious…

统计方法学 · 统计学 2019-10-29 Zeda Li , Ori Rosen , Fabio Ferrarelli , Robert T. Krafty

Dynamic factor models are often estimated by point-estimation methods, disregarding parameter uncertainty. We propose a method accounting for parameter uncertainty by means of posterior approximation, using variational inference. Our…

统计方法学 · 统计学 2022-10-14 Erik Spånberg

Factor analysis models are widely utilized in social and behavioral sciences, such as psychology, education, and marketing, to measure unobservable latent traits. In this article, we introduce a nonlinear structured latent factor analysis…

统计方法学 · 统计学 2025-01-07 Yimang Zhang , Xiaorui Wang , Jian Qing Shi

We investigate the problem of reliably assessing group fairness when labeled examples are few but unlabeled examples are plentiful. We propose a general Bayesian framework that can augment labeled data with unlabeled data to produce more…

机器学习 · 统计学 2020-10-21 Disi Ji , Padhraic Smyth , Mark Steyvers

Mixture models are widely used in modeling heterogeneous data populations. A standard approach of mixture modeling assumes that the mixture component takes a parametric kernel form. In many applications, making parametric assumptions on the…

统计方法学 · 统计学 2026-03-06 Yilei Zhang , Yun Wei , Aritra Guha , XuanLong Nguyen

The flexibility of the Bayesian approach to account for covariates with measurement error is combined with semiparametric regression models for a class of continuous, discrete and mixed univariate response distributions with potentially all…

Under model misspecification, the MLE generally converges to the pseudo-true parameter, the parameter corresponding to the distribution within the model that is closest to the distribution from which the data are sampled. In many problems,…

统计方法学 · 统计学 2012-11-02 Peter Hoff , Jon Wakefield

Functional factor analysis is an important dimension reduction method for functional and longitudinal data. Factor loadings give insight into patterns of variability of the observations, while latent factors provide a low-dimensional…

统计方法学 · 统计学 2026-04-29 James Matuk , Amy H. Herring , David B. Dunson

A family of parsimonious ultrametric mixture models with the Manly transformation is developed for clustering high-dimensional and asymmetric data. Advances in Gaussian mixture modeling sufficiently handle high-dimensional data but struggle…

统计方法学 · 统计学 2025-12-16 Alexa A. Sochaniwsky , Paul D. McNicholas

We present a fully Bayesian statistical approach to the problem of compartmental modelling in the context of Positron Emission Tomography. We cluster homogeneous region of interest and perform kinetic parameter estimation simultaneously. A…

There has been increased research interest in the subfield of sparse Bayesian factor analysis with shrinkage priors, which achieve additional sparsity beyond the natural parsimonity of factor models. In this spirit, we estimate the number…

统计方法学 · 统计学 2023-01-18 Sylvia Frühwirth-Schnatter , Darjus Hosszejni , Hedibert Freitas Lopes