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Tens of millions of women suffer from infertility worldwide each year. In vitro fertilization (IVF) is the best choice for many such patients. However, IVF is expensive, time-consuming, and both physically and emotionally demanding. The…

定量方法 · 定量生物学 2019-11-12 Bo Zhang , Yuqi Cui , Meng Wang , Jingjing Li , Lei Jin , Dongrui Wu

In vitro fertilization (IVF) is a widely utilized assisted reproductive technology, yet predicting its success remains challenging due to the multifaceted interplay of clinical, demographic, and procedural factors. This study develops a…

In clinical In-Vitro Fertilization (IVF), identifying the most viable embryo for transfer is important to increasing the likelihood of a successful pregnancy. Traditionally, this process involves embryologists manually assessing embryos'…

计算机视觉与模式识别 · 计算机科学 2024-10-22 Junsik Kim , Zhiyi Shi , Davin Jeong , Johannes Knittel , Helen Y. Yang , Yonghyun Song , Wanhua Li , Yicong Li , Dalit Ben-Yosef , Daniel Needleman , Hanspeter Pfister

In Vitro Fertilization (IVF) is the most widely used Assisted Reproductive Technology (ART). IVF usually involves controlled ovarian stimulation, oocyte retrieval, fertilization in the laboratory with subsequent embryo transfer. The first…

人工智能 · 计算机科学 2022-01-31 Xizhe Wang , Ning Zhang , Jia Wang , Jing Ni , Xinzi Sun , John Zhang , Zitao Liu , Yu Cao , Benyuan Liu

Infertility, a pressing global health concern, affects a substantial proportion of individuals worldwide. While advancements in assisted reproductive technology (ART) have offered effective interventions, conventional in vitro…

人工智能 · 计算机科学 2025-09-25 Xueqiang Ouyang , Jia Wei

Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study. Classical genetic association studies regress a single…

应用统计 · 统计学 2017-03-22 Hélène Ruffieux , Anthony C. Davison , Jörg Hager , Irina Irincheeva

Joint models for longitudinal and survival data have gained a lot of attention in recent years, with the development of myriad extensions to the basic model, including those which allow for multivariate longitudinal data, competing risks…

统计方法学 · 统计学 2020-03-09 Katya Mauff , Ewout Steyerberg , Isabella Kardys , Eric Boersma , Dimitris Rizopoulos

Temporal embryo images and parental fertility table indicators are both valuable for pregnancy prediction in \textbf{in vitro fertilization embryo transfer} (IVF-ET). However, current machine learning models cannot make full use of the…

计算机视觉与模式识别 · 计算机科学 2025-07-03 Xueqiang Ouyang , Jia Wei , Wenjie Huo , Xiaocong Wang , Rui Li , Jianlong Zhou

Multilevel models (mixed-effect models or hierarchical linear models) are now a standard approach to analysing clustered and longitudinal data in the social, behavioural and medical sciences. This review article focuses on multilevel linear…

统计方法学 · 统计学 2019-07-16 George Leckie

In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically…

Motivation: HIV is difficult to treat because its virus mutates at a high rate and mutated viruses easily develop resistance to existing drugs. If the relationships between mutations and drug resistances can be determined from historical…

定量方法 · 定量生物学 2019-07-08 Li Xing , Mary Lesperance , Xuekui Zhang

To maximize clinical benefit, clinicians routinely tailor treatment to the individual characteristics of each patient, where individualized treatment rules are needed and are of significant research interest to statisticians. In the…

统计方法学 · 统计学 2021-11-23 Trinetri Ghosh , Yanyuan Ma , Rui Song , Pingshou Zhong

The process of fertilizing a human egg outside the body in order to help those suffering from infertility to conceive is known as in vitro fertilization (IVF). Despite being the most effective method of assisted reproductive technology…

Variational inference is a popular method for estimating model parameters and conditional distributions in hierarchical and mixed models, which arise frequently in many settings in the health, social, and biological sciences. Variational…

统计方法学 · 统计学 2019-01-10 Ted Westling , Tyler H. McCormick

Multi-model prediction efforts in infectious disease modeling and climate modeling involve multiple teams independently producing projections under various scenarios. Often these scenarios are produced by the presence and absence of a…

统计方法学 · 统计学 2022-08-11 Yuanhao Lu , Ajitesh Srivastava

Assessing causal effects in the presence of unobserved confounding is a challenging problem. Existing studies leveraged proxy variables or multiple treatments to adjust for the confounding bias. In particular, the latter approach attributes…

统计方法学 · 统计学 2023-10-17 Yong Wu , Mingzhou Liu , Jing Yan , Yanwei Fu , Shouyan Wang , Yizhou Wang , Xinwei Sun

Envelope model also known as multivariate regression model was proposed to solve the multiple response regression problems. It measures the linear association between predictors and multiple responses by using the minimal reducing subspace…

统计方法学 · 统计学 2018-05-07 Bochao Jia

Real-world problems are often dependent on multiple data modalities, making multimodal fusion essential for leveraging diverse information sources. In high-stakes domains, such as in healthcare, understanding how each modality contributes…

神经与进化计算 · 计算机科学 2025-05-19 Mafalda Malafaia , Thalea Schlender , Tanja Alderliesten , Peter A. N. Bosman

An important limitation to the development of Artificial Intelligence (AI)-based solutions for In Vitro Fertilization (IVF) is the absence of a public reference benchmark to train and evaluate deep learning (DL) models. In this work, we…

图像与视频处理 · 电气工程与系统科学 2022-05-16 Tristan Gomez , Magalie Feyeux , Nicolas Normand , Laurent David , Perrine Paul-Gilloteaux , Thomas Fréour , Harold Mouchère

Considerable interest has recently been focused on studying multiple phenotypes simultaneously in both epidemiological and genomic studies, either to capture the multidimensionality of complex disorders or to understand shared etiology of…

统计方法学 · 统计学 2015-11-26 Denis Agniel , Katherine P. Liao , Tianxi Cai
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