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The rapid spread of the Coronavirus SARS-2 is a major challenge that led almost all governments worldwide to take drastic measures to respond to the tragedy. Chief among those measures is the massive lockdown of entire countries and cities,…

Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to…

偏微分方程分析 · 数学 2019-02-28 Pierre Gabriel , Shawn P. Garbett , Vito Quaranta , Darren R. Tyson , Glenn F. Webb

Dynamic processes on networks are fundamental to understanding modern-day phenomena such as information diffusion and opinion polarization on the internet or epidemics spreading through society. However, such processes are notoriously…

物理与社会 · 物理学 2025-07-15 Noam Abadi , Franco Ruzzenenti

Pandemic control measures like lock-down, restrictions on restaurants and gatherings, social-distancing have shown to be effective in curtailing the spread of COVID-19. However, their sustained enforcement has negative economic effects. To…

Epidemiological models increasingly rely on self-reported behavioral data such as vaccination status, mask usage, and social distancing adherence to forecast disease transmission and assess the impact of non-pharmaceutical interventions…

计算机科学与博弈论 · 计算机科学 2026-02-24 Yiqi Su , Christo Kurisummoottil Thomas , Walid Saad , Bud Mishra , Naren Ramakrishnan

Research in epidemiology often focusses on designing interventions that result in the number of infected individuals asymptotically approaching zero, without considering that this number may peak at high values during transients. Recent…

最优化与控制 · 数学 2020-03-24 Willem Esterhuizen , Tim Aschenbruck , Jean Lévine , Stefan Streif

Incorporating decision-making dynamics during an outbreak poses a challenge for epidemiology, faced by several modeling approaches siloed by different disciplines. We propose an epi-economic model where high-frequency choices of individuals…

物理与社会 · 物理学 2025-01-31 Lorenzo Amir Nemati Fard , Alberto Bisin , Michele Starnini , Michele Tizzoni

Although instantaneous interactions are unphysical, a large variety of maximum entropy statistical inference methods match the model-inferred and the empirically-measured equal-time correlation functions. Focusing on collective motion of…

We consider the problem of the optimal allocation of vaccination and protection measures for the Susceptible-Infected-Recovered-Infected (SIRI) epidemiological model, which generalizes the classical Susceptible-Infected-Recovered (SIR) and…

最优化与控制 · 数学 2025-05-09 Urmee Maitra , Ashish R. Hota , Rohit Gupta , Alfred O. Hero

Seasonal variation in environmental variables, and in rates of contact among individuals, are fundamental drivers of infectious disease dynamics. Unlike most periodically-forced physical systems, for which the precise pattern of forcing is…

种群与进化 · 定量生物学 2019-08-09 Irena Papst , David J. D. Earn

As generative models become ubiquitous, there is a critical need for fine-grained control over the generation process. Yet, while controlled generation methods from prompting to fine-tuning proliferate, a fundamental question remains…

人工智能 · 计算机科学 2026-01-12 Emily Cheng , Carmen Amo Alonso , Federico Danieli , Arno Blaas , Luca Zappella , Pau Rodriguez , Xavier Suau

We propose a system theoretic approach to select and stabilize the endemic equilibrium of an SIRS epidemic model in which the decisions of a population of strategically interacting agents determine the transmission rate. Specifically, the…

动力系统 · 数学 2022-01-26 Nuno C. Martins , Jair Certorio , Richard J. La

In this manuscript we consider a class optimal control problem for stochastic differential delay equations. First, we rewrite the problem in a suitable infinite-dimensional Hilbert space. Then, using the dynamic programming approach, we…

最优化与控制 · 数学 2023-02-20 Filippo de Feo , Salvatore Federico , Andrzej Święch

We consider an optimal control problem for a system of local continuity equations on a space of probability measures. Such systems can be viewed as macroscopic models of ensembles of non-interacting particles or homotypic individuals,…

最优化与控制 · 数学 2021-10-07 Maxim Staritsyn , Nikolay Pogodaev , Roman Chertovskih , Fernando Lobo Pereira

A general model of age-structured population dynamics is developed and the fundamental properties of its solutions are analyzed. The model is a semilinear partial differential equation with a nonlinear nonlocal boundary condition.…

偏微分方程分析 · 数学 2016-07-06 Min Gao

A key problem in modelling the evolution dynamics of infectious diseases is the mathematical representation of the mechanism of transmission of the contagion. Models with a finite number of subpopulations can be described via systems of…

最优化与控制 · 数学 2017-03-09 Sebastian Anita , Vincenzo Capasso

In the context of SARS-CoV-2 pandemic, mathematical modelling has played a fundamental role for making forecasts, simulating scenarios and evaluating the impact of preventive political, social and pharmaceutical measures. Optimal control…

最优化与控制 · 数学 2022-11-01 Giovanni Ziarelli , Luca Dede' , Nicola Parolini , Marco Verani , Alfio Quarteroni

Mathematical modeling is one of the key factors of the effective control of newly found infectious diseases, such as COVID-19. Our knowledge about the parameters and the course of the infection is highly limited in the beginning of the…

定量方法 · 定量生物学 2021-10-13 Péter Boldog , Norbert Bogya , Zsolt Vizi

Here we propose and implement a generalized mathematical model to find the time evolution of population in infectious diseases and apply the model to study the recent COVID-19 pandemic. Our model at the core is a non-local generalization of…

种群与进化 · 定量生物学 2020-05-01 Saumyak Mukherjee , Sayantan Mondal , Biman Bagchi

Augmenting classical epidemiological models with information from the social sciences helps unveil the interplay between contagion dynamics and social responses. However, multidisciplinary integration of social analysis and epidemiological…

物理与社会 · 物理学 2025-07-29 Daniele Proverbio , Riccardo Tessarin , Giulia Giordano