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Cell-cell adhesion is established by specific binding of receptor and ligand proteins. The adhesion bonds attract each other and often aggregate into large clusters that are central to many biological processes. One possible origin of…

软凝聚态物质 · 物理学 2016-07-07 Nadiv Dharan , Oded Farago

Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during…

软凝聚态物质 · 物理学 2009-06-10 Thomas R. Weikl , Mesfin Asfaw , Heinrich Krobath , Bartosz Rozycki , Reinhard Lipowsky

We study membrane-protein interactions and membrane-mediated protein-protein interactions by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers with cylindrical hydrophobic inclusions. The strength of the…

生物物理 · 物理学 2009-11-13 Beate West , Frank L. H. Brown , Friederike Schmid

The adhesion of cell membranes is mediated by the binding of membrane-anchored receptor and ligand proteins. In this article, we review recent results from simulations and theory that lead to novel insights on how the binding equilibrium…

生物大分子 · 定量生物学 2016-06-15 Thomas R. Weikl , Jinglei Hu , Guang-Kui Xu , Reinhard Lipowsky

We use a coarse grained molecular model of supported lipid bilayers to study the formation of adhesion domains. We find that this process is a first order phase transition, triggered by a combination of pairwise short range attractive…

软凝聚态物质 · 物理学 2015-06-22 Nadiv Dharan , Oded Farago

Biomimetic membranes in contact with a planar substrate or a second membrane are studied theoretically. The membranes contain specific adhesion molecules (stickers) which are attracted by the second surface. In the absence of stickers, the…

软凝聚态物质 · 物理学 2016-08-31 Thomas R. Weikl , David Andelman , Shigeyuki Komura , Reinhard Lipowsky

Modeling membrane interactions with arbitrarily shaped colloidal particles, such as environmental micro- and nanoplastics, at the cell scale remains particularly challenging, owing to the complexity of particle geometries and the need to…

软凝聚态物质 · 物理学 2025-09-15 Didarul Ahasan Redwan , Justin Reicher , Xin Yong

We theoretically consider specific adhesion of a fluctuating membrane to a hard substrate via the formation of bonds between receptors attached to the substrate and ligands in the membrane. By integrating out the degrees of freedom of the…

软凝聚态物质 · 物理学 2010-10-13 Thomas Speck , Ellen Reister , Udo Seifert

Interactions mediated by the cell membrane between inclusions, such as membrane proteins or antimicrobial peptides, play important roles in their biological activity. They also constitute a fascinating challenge for physicists, since they…

生物物理 · 物理学 2019-03-15 Anne-Florence Bitbol , Doru Constantin , Jean-Baptiste Fournier

Adhesion between membranes is studied using a phenomenological model, where the inter-membrane distance is coupled to the concentration of sticker molecules on the membranes. The model applies to both for adhesion of two flexible membranes…

软凝聚态物质 · 物理学 2012-01-31 Shigeyuki Komura , David Andelman

Adhesion processes of biological membranes that enclose cells and cellular organelles are essential for immune responses, tissue formation, and signaling. These processes depend sensitively on the binding constant K2D of the…

生物大分子 · 定量生物学 2015-11-30 Guang-Kui Xu , Jinglei Hu , Reinhard Lipowsky , Thomas R. Weikl

The adhesion of cells is mediated by receptors and ligands anchored in apposing membranes. A central question is how to characterize the binding affinity of these membrane-anchored molecules. For soluble molecules, the binding affinity is…

软凝聚态物质 · 物理学 2009-06-03 Heinrich Krobath , Bartosz Rozycki , Reinhard Lipowsky , Thomas R. Weikl

The adhesion of biological membranes is mediated by the binding of membrane-anchored receptor and ligand proteins. Central questions are how the binding kinetics of these proteins is affected by the membranes and by the membrane anchoring…

生物大分子 · 定量生物学 2015-11-30 Jinglei Hu , Guang-Kui Xu , Reinhard Lipowsky , Thomas R. Weikl

Structural lubricity arises typically at incommensurate, well-defined dry contacts where short-range elastic instability is significantly mitigated. However, under ambient conditions, airborne molecules adsorb onto solid surfaces, forming…

材料科学 · 物理学 2024-08-30 Hongyu Gao , Sergey Sukhomlinov

We consider the evolution and interaction of a 2-dimensional nematic liquid crystal of Ericksen-Leslie type within a 1-dimensional flexible viscoelastic structure. This is a fully macroscopic model in which the nematic liquid crystal is…

偏微分方程分析 · 数学 2026-05-08 Prince Romeo Mensah

A model system has been recently developed to study adhesion. It consists of a giant lipid bilayer vesicle with reconstituted lipo-polymers (repellers) as well as with lipo-ligands recognized by receptors covering the substrate. Adhesion in…

软凝聚态物质 · 物理学 2007-05-23 A. Boulbitch

Many biological systems fold thin sheets of lipid membrane into complex three-dimensional structures. This microscopic origami is often mediated by the adsorption and self-assembly of proteins on a membrane. As a model system to study…

软凝聚态物质 · 物理学 2016-10-11 Raphael Sarfati , Eric R. Dufresne

In systems composed of water and hydrocarbons Van der Waals-interactions are dominated by the non-retarded, classical (Keesom) part of the Lifshitz-interaction; the interaction is screened by salt and extends over mesoscopic distances of…

统计力学 · 物理学 2007-11-09 I. Pasichnyk , R. Everaers , A. C. Maggs

In this work a Lattice Boltzmann Immersed Boundary method is used for predicting the dynamics of rigid and deformable adhesive micro carriers (1 um) navigating a capillary by the size of 10 um with 20% hematocrit. Red cells and particles…

软凝聚态物质 · 物理学 2020-08-31 Alessandro Coclite

Molecular dynamics simulations are used to study structure formation in simple model polymer chains that are subject to excluded volume and torsional interactions. The changing conformations exhibited by chains of different lengths under…

软凝聚态物质 · 物理学 2009-11-07 D. C. Rapaport
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