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In pharmacoepidemiology research, instrumental variables (IVs) are variables that strongly predict treatment but have no causal effect on the outcome of interest except through the treatment. There remain concerns about the inclusion of IVs…

统计方法学 · 统计学 2024-03-22 Yuxi Tian , Nicole Pratt , Laura L Hester , George Hripcsak , Martijn J Schuemie , Marc A Suchard

In this paper we address the challenges posed by non-proportional hazards and informative censoring, offering a path toward more meaningful causal inference conclusions. We start from the marginal structural Cox model, which has been widely…

统计方法学 · 统计学 2023-11-15 Jiyu Luo , Denise Rava , Jelena Bradic , Ronghui Xu

Propensity score matching is a tool for causal inference in non-randomized studies that allows for conditioning on large sets of covariates. The use of propensity scores in the social sciences is currently experiencing a tremendous…

应用统计 · 统计学 2012-02-01 Felix Thoemmes

For the analysis of time-to-event data, frequently used methods such as the log-rank test or the Cox proportional hazards model are based on the proportional hazards assumption, which is often debatable. Although a wide range of parametric…

The propensity score analysis is one of the most widely used methods for studying the causal treatment effect in observational studies. This paper studies treatment effect estimation with the method of matching weights. This method…

统计方法学 · 统计学 2011-05-17 Liang Li

It is generally believed that bias is minimized in well-controlled randomized clinical trials. However, bias can arise in active controlled noninferiority trials because the inference relies on a previously estimated effect size obtained…

应用统计 · 统计学 2013-12-02 Lei Nie , Zhiwei Zhang , Daniel Rubin , Jianxiong Chu

Missing attributes are ubiquitous in causal inference, as they are in most applied statistical work. In this paper, we consider various sets of assumptions under which causal inference is possible despite missing attributes and discuss…

统计方法学 · 统计学 2020-05-25 Imke Mayer , Erik Sverdrup , Tobias Gauss , Jean-Denis Moyer , Stefan Wager , Julie Josse

Confounding remains one of the major challenges to causal inference with observational data. This problem is paramount in medicine, where we would like to answer causal questions from large observational datasets like electronic health…

统计方法学 · 统计学 2024-01-10 Linying Zhang , Yixin Wang , Martijn Schuemie , David Blei , George Hripcsak

When a strict subset of covariates are given, we propose conditional quantile treatment effect to capture the heterogeneity of treatment effects via the quantile sheet that is the function of the given covariates and quantile. We focus on…

统计理论 · 数学 2020-09-23 Niwen Zhou , Xu Guo , Lixing Zhu

To strengthen inferences meta analyses are commonly used to summarize information from a set of independent studies. In some cases, though, the data may not satisfy the assumptions underlying the meta analysis. Using three Bayesian methods…

应用统计 · 统计学 2022-04-07 Dexter Cahoy , Joseph Sedransk

To make informative public policy decisions in battling the ongoing COVID-19 pandemic, it is important to know the disease prevalence in a population. There are two intertwined difficulties in estimating this prevalence based on testing…

统计方法学 · 统计学 2020-12-01 Bryan Cai , John P. A. Ioannidis , Eran Bendavid , Lu Tian

Propensity score methods have been shown to be powerful in obtaining efficient estimators of average treatment effect (ATE) from observational data, especially under the existence of confounding factors. When estimating, deciding which type…

统计方法学 · 统计学 2021-09-14 Kangjie Zhou , Jinzhu Jia

Observational cohort studies with oversampled exposed subjects are typically implemented to understand the causal effect of a rare exposure. Because the distribution of exposed subjects in the sample differs from the source population,…

统计方法学 · 统计学 2019-02-14 Sherri Rose

Propensity score trimming, which discards subjects with propensity scores below a threshold, is a common way to address positivity violations that complicate causal effect estimation. However, most works on trimming assume treatment is…

统计方法学 · 统计学 2024-07-31 Zach Branson , Edward H. Kennedy , Sivaraman Balakrishnan , Larry Wasserman

Studies of the effects of medical interventions increasingly take place in distributed research settings using data from multiple clinical data sources including electronic health records and administrative claims. In such settings, privacy…

统计方法学 · 统计学 2021-01-06 Martijn J. Schuemie , Yong Chen , David Madigan , Marc A. Suchard

Effective property prediction methods can help accelerate the search for COVID-19 antivirals either through accurate in-silico screens or by effectively guiding on-going at-scale experimental efforts. However, existing prediction tools have…

定量方法 · 定量生物学 2020-05-08 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Propensity score matching (PSM) is a pseudo-experimental method that uses statistical techniques to construct an artificial control group by matching each treated unit with one or more untreated units of similar characteristics. To date,…

统计理论 · 数学 2022-05-27 Yukun Liu , Jing Qin

Traditionally, data scientists use exploratory data analysis techniques such as correlation analysis, summary statistics, and regression analysis for identifying the most product enhancements and roadmap planning. However, these…

应用统计 · 统计学 2024-06-06 Adam Gajtkowski , Felipe Moraes

We study Bayesian approaches to causal inference via propensity score regression. Much of the Bayesian literature on propensity score methods have relied on approaches that cannot be viewed as fully Bayesian in the context of conventional…

统计方法学 · 统计学 2022-02-01 David A. Stephens , Widemberg S. Nobre , Erica E. M. Moodie , Alexandra M. Schmidt

Collaboration between different data centers is often challenged by heterogeneity across sites. To account for the heterogeneity, the state-of-the-art method is to re-weight the covariate distributions in each site to match the distribution…

机器学习 · 统计学 2024-04-25 Tianyu Guo , Sai Praneeth Karimireddy , Michael I. Jordan