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We introduce TempoCave, a novel visualization application for analyzing dynamic brain networks, or connectomes. TempoCave provides a range of functionality to explore metrics related to the activity patterns and modular affiliations of…

人机交互 · 计算机科学 2020-01-16 Ran Xu , Manu Mathew Thomas , Alex Leow , Olusola Ajilore , Angus G. Forbes

Motivation. While recent studies show high accuracy in the classification of Alzheimer's disease using deep neural networks, the underlying learned concepts have not been investigated. Goals. To systematically identify changes in brain…

Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…

神经元与认知 · 定量生物学 2024-11-01 Hina Shaheen , Roderick Melnik

The goal of diffusion-weighted magnetic resonance imaging (DWI) is to infer the structural connectivity of an individual subject's brain in vivo. To statistically study the variability and differences between normal and abnormal brain…

神经元与认知 · 定量生物学 2023-03-06 Haocheng Dai , Martin Bauer , P. Thomas Fletcher , Sarang Joshi

Label noise in training data can significantly degrade a model's generalization performance for supervised learning tasks. Here we focus on the problem that noisy labels are primarily mislabeled samples, which tend to be concentrated near…

机器学习 · 计算机科学 2021-03-16 Hao-Chiang Shao , Hsin-Chieh Wang , Weng-Tai Su , Chia-Wen Lin

The connectome, or the entire connectivity of a neural system represented by network, ranges various scales from synaptic connections between individual neurons to fibre tract connections between brain regions. Although the modularity they…

神经元与认知 · 定量生物学 2014-10-01 Jinseop S. Kim , Marcus Kaiser

This paper introduces a new probabilistic framework for supervised learning in neural systems. It is designed to model complex, uncertain systems whose random outputs are strongly non-Gaussian given deterministic inputs. The architecture…

机器学习 · 统计学 2025-12-12 Christian Soize

Brain network analysis provides an interpretable framework for characterizing brain organization and has been widely used for neurological disorder identification. Recent advances in self-supervised learning have motivated the development…

计算机视觉与模式识别 · 计算机科学 2026-03-24 Jiaxing Xu , Jingying Ma , Xin Lin , Yuxiao Liu , Kai He , Qika Lin , Yiping Ke , Yang Li , Dinggang Shen , Mengling Feng

We propose an algorithm grounded in dynamical systems theory that generalizes manifold learning from a global state representation, to a network of local interacting manifolds termed a Generative Manifold Network (GMN). Manifolds are…

Convolutional neural networks are ubiquitous in Machine Learning applications for solving a variety of problems. They however can not be used in their native form when the domain of the data is commonly encountered manifolds such as the…

计算机视觉与模式识别 · 计算机科学 2018-08-08 Rudrasis Chakraborty , Monami Banerjee , Baba C. Vemuri

This paper advocates Riemannian multi-manifold modeling in the context of network-wide non-stationary time-series analysis. Time-series data, collected sequentially over time and across a network, yield features which are viewed as points…

Brain lesion and anatomy segmentation in magnetic resonance images are fundamental tasks in neuroimaging research and clinical practice. Given enough training data, convolutional neuronal networks (CNN) proved to outperform all existent…

计算机视觉与模式识别 · 计算机科学 2019-04-16 Nicolas Roulet , Diego Fernandez Slezak , Enzo Ferrante

Recordings of whole brain activity with single neuron resolution are now feasible in simple organisms. Yet, it is still challenging to appropriately simplify such complex, noisy, and multivariate data in order to reveal general principles…

神经元与认知 · 定量生物学 2017-11-27 Connor Brennan , Alex Proekt

Understanding how large-scale functional brain networks reorganize during cognitive decline remains a central challenge in neuroimaging. While recent self-supervised models have shown promise for learning representations from resting-state…

机器学习 · 计算机科学 2026-03-03 Karanpartap Singh , Adam Turnbull , Mohammad Abbasi , Kilian Pohl , Feng Vankee Lin , Ehsan Adeli

The brain age is a key indicator of brain health. While electroencephalography (EEG) is a practical tool for this task, existing models struggle with the common challenge of imperfect medical data, such as learning a ``normal'' baseline…

机器学习 · 计算机科学 2025-11-25 Kunyu Zhang , Mingxuan Wang , Xiangjie Shi , Haoxing Xu , Chao Zhang

Mechanistic models of progressive neurodegeneration offer great potential utility for clinical use and novel treatment development. Toward this end, several connectome-informed models of neuroimaging biomarkers have been proposed. However,…

定量方法 · 定量生物学 2025-08-15 Daniel Semchin , Emile d'Angremont , Marco Lorenzi , Boris Gutman

Emerging evidence showed that major depressive disorder (MDD) is associated with disruptions of brain structural and functional networks, rather than impairment of isolated brain region. Thus, connectome-based models capable of predicting…

神经元与认知 · 定量生物学 2021-10-18 Aya Kabbara , Gabriel Robert , Mohamad Khalil , Marc Verin , Pascal Benquet , Mahmoud Hassan

Motivated by the analysis of high-dimensional neuroimaging signals located over the cortical surface, we introduce a novel Principal Component Analysis technique that can handle functional data located over a two-dimensional manifold. For…

应用统计 · 统计学 2019-08-02 Eardi Lila , John A. D. Aston , Laura M. Sangalli

Optimization over the Stiefel manifold is a fundamental computational problem in many scientific and engineering applications. Despite considerable research effort, high-dimensional optimization problems over the Stiefel manifold remain…

最优化与控制 · 数学 2025-05-16 Andy Yat-Ming Cheung , Jinxin Wang , Man-Chung Yue , Anthony Man-Cho So

Empirical studies over the past two decades have supported the hypothesis that schizophrenia is characterized by altered connectivity patterns in functional brain networks. These alterations have been proposed as genetically-mediated…

神经元与认知 · 定量生物学 2013-06-28 Felix Siebenhuhner , Shennan A. Weiss , Richard Coppola , Daniel R. Weinberger , Danielle S. Bassett
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