相关论文: The societal impact of ion beam therapy

Radiation damage induced by ion beams is traditionally treated at different levels of theoretical approaches, for the different scales and mechanisms involved.We present here details of a combined approach that, from a method at a…

The physical and clinical benefits of charged particle therapy (CPT) are well recognised and recent developments have led to the rapid emergence of facilities, resulting in wider adoption worldwide. Nonetheless, the availability of CPT and…

Proton therapy exploits the finite range of charged particles in tissue to achieve dose distributions no photon based modality can replicate. Yet the modality reaches fewer than 1 percent of patients who might benefit a gap rooted in cost…

According to the World Health Organization, more than one billion people worldwide have disabilities. The field of disability studies defines disability through a social lens; people are disabled to the extent that society creates…

We study how nonlinear, state-dependent health dynamics shape economic behavior, inequality, and the evaluation of disability insurance at older ages. Using English panel data, we construct a continuous health index and estimate its…

Ion beam has been used in cancer treatment, and has a unique preferable feature to deposit its main energy inside a human body so that cancer cell could be killed by the ion beam. However, conventional ion accelerator tends to be huge in…

Radiation therapy aims to deliver the prescribed amount of dose to a tumour at the same time as sparing the surrounding tissues as much as possible. In charged particle therapy, delivering the prescribed dose is equivalent to delivering the…

Dynamic treatment regimes have been proposed to personalize treatment decisions by utilizing historical patient data, but they may not always improve on the current standard of care. It is thus meaningful to integrate the standard of care…

Cancer therapy using protons and heavier ions such as carbon has demonstrated advantages over other radiotherapy treatments. To bring about the next generation of clinical facilities, the requirements are likely to reduce the footprint,…

Due to increasing environmental and economic constraints, optimization of ion beam transport and equipment design becomes essential. The future should be equipped with planet-friendly facilities, that is, solutions that reduce environmental…

A dynamic treatment regime is a sequence of medical decisions that adapts to the evolving clinical status of a patient over time. To facilitate personalized care, it is crucial to assess the probability of each available treatment option…

Treatment delivery is largely determined by capabilities of the beam delivery system (BDS), where faster delivery can have many potential benefits including improved dosimetric quality, utility, cost effectiveness, patient throughput and…

In oncology, treating cancer with a beam of photons is a well established therapeutic technique, developed over 100 years, and today over 50% of cancer patients will undergo traditional X-ray radiotherapy. However, ionizing radiation…

With the continued evolution of modern radiation therapy towards high precision delivery of high therapeutic doses to the tumour while optimally sparing surrounding healthy tissue, imaging becomes a crucial component to identify the…

We propose a multi-scale approach to understand the physics related to ion-beam cancer therapy. It allows the calculation of the probability of DNA damage as a result of irradiation of tissues with energetic ions, up to 430 MeV/u. This…

Electromagnetic radiation (photons) or particle beam (protons or heavy ions) have similar biological effects, i.e. damage to human cell DNA that eventually leads to cell death if not correctly repaired. The biological effects at the level…

Beams of radioactive heavy ions allow researchers to study rare and unstable atomic nuclei, shedding light into the internal structure of exotic nuclei and on how chemical elements are formed in stars. However, the extraction and transport…

Artificial intelligence is humanity's most promising technology because of the remarkable capabilities offered by foundation models. Yet, the same technology brings confusion and consternation: foundation models are poorly understood and…

We are in a golden age of progress in artificial intelligence (AI). Radiotherapy, due to its technology-intensive nature as well as direct human-machine interactions, is perfectly suited for benefitting from AI to enhance accuracy and…

An important objective in the development of targeted therapies is to identify the populations where the treatment under consideration has positive benefit risk balance. We consider pivotal clinical trials, where the efficacy of a treatment…