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Pre-symptomatic (or Preclinical) Alzheimer's Disease is defined by biomarker evidence of fibrillar amyloid beta pathology in the absence of clinical symptoms. Clinical trials in this early phase of disease are challenging due to the slow…

应用统计 · 统计学 2020-03-10 Dan Li , Samuel Iddi , Paul S. Aisen , Wesley K. Thompson , Michael C. Donohue

Automatic Speech Recognition (ASR) is a critical component of any fully-automated speech-based dementia detection model. However, despite years of speech recognition research, little is known about the impact of ASR accuracy on dementia…

计算与语言 · 计算机科学 2020-10-15 Aparna Balagopalan , Ksenia Shkaruta , Jekaterina Novikova

We propose an automatic detection method of Alzheimer's diseases using a gated convolutional neural network (GCNN) from speech data. This GCNN can be trained with a relatively small amount of data and can capture the temporal information in…

音频与语音处理 · 电气工程与系统科学 2018-04-02 Tifani Warnita , Nakamasa Inoue , Koichi Shinoda

Data sets for identifying Alzheimer's disease (AD) are often relatively sparse, which limits their ability to train generalizable models. Here, we augment such a data set, DementiaBank, with each of two normative data sets, the Wisconsin…

计算与语言 · 计算机科学 2017-12-04 Zeinab Noorian , Chloé Pou-Prom , Frank Rudzicz

Dementia diagnosis requires a series of different testing methods, which is complex and time-consuming. Early detection of dementia is crucial as it can prevent further deterioration of the condition. This paper utilizes a speech…

计算与语言 · 计算机科学 2023-12-18 Zih-Jyun Lin , Yi-Ju Chen , Po-Chih Kuo , Likai Huang , Chaur-Jong Hu , Cheng-Yu Chen

Alzheimer disease (AD) is a neurodegenerative disease that lacks specific treatment options. Natural drugs have displayed neuroprotective effects; however, their high-throughput discovery is challenging because of the expense of…

其他定量生物学 · 定量生物学 2026-04-28 Hafiza Syeda Yusra Tirmizi , Syed Ibad Hasnain , Muhammad Faris , Rabail Khowaja , Saad Abdullah

Alzheimer's disease (AD) is a neurodegenerative disorder with no known cure that affects tens of millions of people worldwide. Early detection of AD is critical for timely intervention to halt or slow the progression of the disease. In this…

机器学习 · 计算机科学 2025-07-08 Mahdi Moghaddami , Clayton Schubring , Mohammad-Reza Siadat

Early prediction of Alzheimer's disease (AD) is crucial for timely intervention and treatment. This study aims to use machine learning approaches to analyze longitudinal electronic health records (EHRs) of patients with AD and identify…

Alzheimer's Disease (AD) ravages the cognitive ability of more than 5 million Americans and creates an enormous strain on the health care system. This paper proposes a machine learning predictive model for AD development without medical…

定量方法 · 定量生物学 2020-06-17 Courtney Cochrane , David Castineira , Nisreen Shiban , Pavlos Protopapas

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that leads to dementia, and early intervention can greatly benefit from analyzing linguistic abnormalities. In this work, we explore the potential of Large Language Models…

计算与语言 · 计算机科学 2025-12-23 Chuyuan Li , Raymond Li , Thalia S. Field , Giuseppe Carenini

Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease…

计算机视觉与模式识别 · 计算机科学 2025-11-27 Xin Honga , Jie Lin , Minghui Wang

Early and accessible detection of Alzheimer's disease (AD) remains a major challenge, as current diagnostic methods often rely on costly and invasive biomarkers. Speech and language analysis has emerged as a promising non-invasive and…

音频与语音处理 · 电气工程与系统科学 2026-03-06 Franziska Braun , Christopher Witzl , Florian Hönig , Elmar Nöth , Tobias Bocklet , Korbinian Riedhammer

Early detection of dementia is critical for timely medical intervention and improved patient outcomes. Neuropsychological tests are widely used for cognitive assessment but have traditionally relied on manual scoring. Automatic dementia…

机器学习 · 计算机科学 2025-07-15 Liming Wang , Saurabhchand Bhati , Cody Karjadi , Rhoda Au , James Glass

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

计算机视觉与模式识别 · 计算机科学 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

Automated diagnosis of Alzheimer Disease(AD) from brain imaging, such as magnetic resonance imaging (MRI), has become increasingly important and has attracted the community to contribute many deep learning methods. However, many of these…

图像与视频处理 · 电气工程与系统科学 2024-03-01 Yifeng Wang , Ke Chen , Haohan Wang

Deep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of healthcare. This study focuses on…

计算机视觉与模式识别 · 计算机科学 2024-05-21 Nida Nasir , Muneeb Ahmed , Neda Afreen , Mustafa Sameer

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that progressively impairs memory, decision-making, and overall cognitive function. As AD is irreversible, early prediction is critical for timely intervention and…

计算机视觉与模式识别 · 计算机科学 2025-12-01 Mahdieh Behjat Khatooni , Mohsen Soryani

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural…

图像与视频处理 · 电气工程与系统科学 2025-07-15 Yang Ming , Jiang Shi Zhong , Zhou Su Juan

Fine-tuned Bidirectional Encoder Representations from Transformers (BERT)-based sequence classification models have proven to be effective for detecting Alzheimer's Disease (AD) from transcripts of human speech. However, previous research…

计算与语言 · 计算机科学 2020-11-13 Aparna Balagopalan , Jekaterina Novikova

A number of life threatening neuro-degenerative disorders had degraded the quality of life for the older generation in particular. Dementia is one such symptom which may lead to a severe condition called Alzheimer's disease if not detected…

神经与进化计算 · 计算机科学 2024-02-01 Anuvab Sen , Udayon Sen , Subhabrata Roy