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Post-translational modifications (PTMs) profoundly expand the complexity and functionality of the proteome, regulating protein attributes and interactions that are crucial for biological processes. Accurately predicting PTM sites and their…

机器学习 · 计算机科学 2024-11-05 Cheng Tan , Zhenxiao Cao , Zhangyang Gao , Lirong Wu , Siyuan Li , Yufei Huang , Jun Xia , Bozhen Hu , Stan Z. Li

Spin-Transfer Torque RAM (STTRAM) is promising for cache applications. However, it brings new data security issues that were absent in volatile memory counterparts such as Static RAM (SRAM) and embedded Dynamic RAM (eDRAM). This is…

密码学与安全 · 计算机科学 2016-03-22 Nitin Rathi , Asmit De , Helia Naeimi , Swaroop Ghosh

Modern processors utilize an increasingly large register set to facilitate efficient floating point and SIMD computation. This large register set is a burden for operating systems, as its content needs to be saved and restored when the…

操作系统 · 计算机科学 2018-06-21 Julian Stecklina , Thomas Prescher

As the High Performance Computing world moves towards the Exa-Scale era, huge amounts of data should be analyzed, manipulated and stored. In the traditional storage/memory hierarchy, each compute node retains its data objects in its local…

分布式、并行与集群计算 · 计算机科学 2021-09-07 Yehonatan Fridman , Yaniv Snir , Matan Rusanovsky , Kfir Zvi , Harel Levin , Danny Hendler , Hagit Attiya , Gal Oren

The emerging hybrid DRAM-NVM architecture is challenging the existing memory management mechanism in operating system. In this paper, we introduce memos, which can schedule memory resources over the entire memory hierarchy including cache,…

操作系统 · 计算机科学 2017-03-23 Lei Liu , Mengyao Xie , Hao Yang

Content-Centric Networking (CCN) offers a novel architectural paradigm that seeks to address the inherent limitations of the prevailing Internet Protocol (IP)-based networking model. In contrast to the host-centric communication approach of…

网络与互联网体系结构 · 计算机科学 2025-08-05 Azadeh Sadat Miraftab , Ahmadreza Montazerolghaem , Behrad Mahboobi

Even with generational improvements in DRAM technology, memory access latency still remains the major bottleneck for application accelerators, primarily due to limitations in memory interface IPs which cannot fully account for variations in…

硬件体系结构 · 计算机科学 2021-08-24 Sasindu Wijeratne , Sanket Pattnaik , Zhiyu Chen , Rajgopal Kannan , Viktor Prasanna

Persistent memory (pmem) products bring the persistence domain up to the memory level. Intel recently introduced the eADR feature that guarantees to flush data buffered in CPU cache to pmem on a power outage, thereby making the CPU cache a…

硬件体系结构 · 计算机科学 2022-11-01 Chongnan Ye , Meng Chen , Qisheng Jiang , Chundong Wang

Resistive Random Access Memory (ReRAM) based Processing In Memory (PIM) Accelerator has emerged as a promising computing architecture for memory intensive applications, such as Deep Neural Networks (DNNs). However, due to its immaturity,…

新兴技术 · 计算机科学 2023-12-19 Je-Woo Jang , Thai-Hoang Nguyen , Joon-Sung Yang

Processing-in-cache (PiC) and Processing-in-memory (PiM) architectures, especially those utilizing bit-line computing, offer promising solutions to mitigate data movement bottlenecks within the memory hierarchy. While previous studies have…

计算机与社会 · 计算机科学 2024-07-30 Dhruv Gajaria , Tosiron Adegbija , Kevin Gomez

Genome analysis has revolutionized fields such as personalized medicine and forensics. Modern sequencing machines generate vast amounts of fragmented strings of genome data called reads. The alignment of these reads into a complete DNA…

硬件体系结构 · 计算机科学 2024-11-22 Rotem Ben-Hur , Orian Leitersdorf , Ronny Ronen , Lidor Goldshmidt , Idan Magram , Lior Kaplun , Leonid Yavitz , Shahar Kvatinsky

Spiking neural networks (SNNs) have shown a potential for having low energy with unsupervised learning capabilities due to their biologically-inspired computation. However, they may suffer from accuracy degradation if their processing is…

硬件体系结构 · 计算机科学 2023-03-06 Rachmad Vidya Wicaksana Putra , Muhammad Abdullah Hanif , Muhammad Shafique

AI chips commonly employ SRAM memory as buffers for their reliability and speed, which contribute to high performance. However, SRAM is expensive and demands significant area and energy consumption. Previous studies have explored replacing…

硬件体系结构 · 计算机科学 2023-12-07 Duy-Thanh Nguyen , Abhiroop Bhattacharjee , Abhishek Moitra , Priyadarshini Panda

Adjusting the latency, power, and accuracy of natural language understanding models is a desirable objective of an efficient architecture. This paper proposes an efficient Transformer architecture that adjusts the inference computational…

计算与语言 · 计算机科学 2024-09-20 Sajjad Kachuee , Mohammad Sharifkhani

Heterogeneous Memory Architecture (HMA) aims to optimize memory usage by leveraging a combination of memory types, such as high-bandwidth memory (HBM), commodity DRAM, and non-volatile memory (NVM), when utilized as main memory. To achieve…

硬件体系结构 · 计算机科学 2026-04-23 Upasna , Venkata Kalyan Tavva

Storage Class Memory (SCM) is a class of memory technology which has recently become viable for use. Their namearises from the fact that they exhibit non-volatility of data, similar to secondary storage while also having latencies…

硬件体系结构 · 计算机科学 2019-09-27 Aditya K Kamath , Leslie Monis , A Tarun Karthik , Basavaraj Talawar

In modern computer architectures, the performance of many memory-bound workloads (e.g., machine learning, graph processing, databases) is limited by the data movement bottleneck that emerges when transferring large amounts of data between…

分布式、并行与集群计算 · 计算机科学 2025-08-12 Pedro Carrinho , Hamid Moghadaspour , Oscar Ferraz , João Dinis Ferreira , Yann Falevoz , Vitor Silva , Gabriel Falcao

A novel deep neural network (DNN) architecture is proposed wherein the filtering and linear transform are realized solely with product quantization (PQ). This results in a natural implementation via content addressable memory (CAM), which…

机器学习 · 计算机科学 2022-08-30 Jie Ran , Rui Lin , Jason Chun Lok Li , Jiajun Zhou , Ngai Wong

Despite their remarkable capabilities, Large Language Models (LLMs) struggle to effectively leverage historical interaction information in dynamic and complex environments. Memory systems enable LLMs to move beyond stateless interactions by…

With emerging storage-class memory (SCM) nearing commercialization, there is evidence that it will deliver the much-anticipated high density and access latencies within only a few factors of DRAM. Nevertheless, the latency-sensitive nature…