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Optical coherence tomography (OCT) has seen widespread success as an in vivo clinical diagnostic 3D imaging modality, impacting areas including ophthalmology, cardiology, and gastroenterology. Despite its many advantages, such as high…

We present a general theory of optical coherence tomography (OCT), which synthesizes the fundamental concepts and implementations of OCT under a common 3D k-space framework. At the heart of this analysis is the Fourier diffraction theorem,…

光学 · 物理学 2021-06-28 Kevin C. Zhou , Ruobing Qian , Al-Hafeez Dhalla , Sina Farsiu , Joseph A. Izatt

Modern imaging techniques at the molecular scale rely on utilizing novel coherent light sources like X-ray free electron lasers for the ultimate goal of visualizing such objects as individual biomolecules rather than crystals. Here, unlike…

Optical imaging plays a critical role in advancing our understanding of three dimensional dynamics of biological systems. Coherent imaging (CI) methods exploit spatial phase information, encoded through propagation of coherent signal light…

光学 · 物理学 2015-07-24 Jeffrey J. Field , David G. Winters , Randy A. Bartels

Deconvolution phase microscopy enables high-contrast visualization of transparent samples through reconstructions of their transmitted phases or refractive indexes. Herein, we propose a method to extend 2D deconvolution phase microscopy to…

光学 · 物理学 2022-04-20 Herve Hugonnet , Mahn Jae Lee , Yongkeun Park

Optical coherence tomography (OCT) is a non-invasive, micrometer-scale imaging modality that has become a clinical standard in ophthalmology. By raster-scanning the retina, sequential cross-sectional image slices are acquired to generate…

图像与视频处理 · 电气工程与系统科学 2024-02-20 Stefan Ploner , Jungeun Won , Julia Schottenhamml , Jessica Girgis , Kenneth Lam , Nadia Waheed , James Fujimoto , Andreas Maier

We highlight the impact of Emil Wolf's work on coherence and polarization on an ever increasing amount of applications in the 21 st century. We present a brief review of how partial coherence at the level of increasing order of coherence…

光学 · 物理学 2020-01-17 Girish S. Agarwal , Anton Classen

Methods of three-dimensional deconvolution (3DD) or volumetric deconvolution of optical complex-valued wavefronts diffracted by 3D samples with the 3D point spread function are presented. Particularly, the quantitative correctness of the…

光学 · 物理学 2022-01-11 Tatiana Latychevskaia

Refractive Index Tomography is the inverse problem of reconstructing the continuously-varying 3D refractive index in a scene using 2D projected image measurements. Although a purely refractive field is not directly visible, it bends light…

计算机视觉与模式识别 · 计算机科学 2023-12-06 Brandon Zhao , Aviad Levis , Liam Connor , Pratul P. Srinivasan , Katherine L. Bouman

In this paper, we study the mathematical imaging problem of diffraction tomography (DT), which is an inverse scattering technique used to find material properties of an object by illuminating it with probing waves and recording the…

For partially coherent light fields with random fluctuations, the intensity distributions and statistics have been proven to be more propagation robust compared with coherent light. However, its full potential in practical applications has…

光学 · 物理学 2023-03-30 Xingyuan Lu , Zhuoyi Wang , Qiwen Zhan , Yangjian Cai , Chengliang Zhao

Holographic coherent X-ray imaging enables nanoscale imaging of biological cells and tissues, rendering both phase and absorption contrast, i.e. real and imaginary parts of the refractive index. Unlike the standard model, which assumes a…

偏微分方程分析 · 数学 2026-05-29 Thorsten Hohage , Milad Karimi , Björn Müller

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing…

A broad class of imaging modalities involve the resolution of an inverse-scattering problem. Among them, three-dimensional optical diffraction tomography (ODT) comes with its own challenges. These include a limited range of views, a large…

图像与视频处理 · 电气工程与系统科学 2020-04-20 Thanh-an Pham , Emmanuel Soubies , Ahmed Ayoub , Joowon Lim , Demetri Psaltis , Michael Unser

We use a spatial light modulator in a diffraction tomographic system to assess the accuracy of different refractive index reconstruction algorithms. Optical phase conjugation principles through complex media, allows us to quantify the error…

光学 · 物理学 2019-10-02 Ahmed B. Ayoub , Thanh-An Pham , Joowon Lim , Michael Unser , Demetri Psaltis

Coherent Diffractive Imaging is a lensless technique that allows imaging of matter at a spatial resolution not limited by lens aberrations. This technique exploits the measured diffraction pattern of a coherent beam scattered by periodic…

Quantitative phase imaging (QPI) is a label-free technique that provides optical path length information for transparent specimens, finding utility in biology, materials science, and engineering. Here, we present quantitative phase imaging…

The Wavelength-shifting Optical Module (WOM) is a novel photosensor concept for the instrumentation of large detector volumes with single-photon sensitivity. The key objective is to improve the signal-to-noise ratio which is achieved by…

Biological tissues are composed of discrete compartments of biochemical media that often exhibit subtle differences in refractive index. Light propagating through these compartments partially diffracts in a forward direction with a pi/2…

光学 · 物理学 2025-05-12 Gregory N. McKay , Jerome Mertz , Nicholas J. Durr

We consider the imaging problem of the reconstruction of a three-dimensional object via optical diffraction tomography under the assumptions of the Born approximation. Our focus lies in the situation that a rigid object performs an…

数值分析 · 数学 2024-07-11 Robert Beinert , Michael Quellmalz