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RNAs are negatively charged molecules residing in macromolecular crowding cellular environments. Macromolecular confinement can influence the ion effects in RNA folding. In this work, using the recently developed tightly bound ion model for…

生物物理 · 物理学 2015-06-15 Zhi-Jie Tan , Shi-Jie Chen

Signal models based on sparse representations have received considerable attention in recent years. On the other hand, deep models consisting of a cascade of functional layers, commonly known as deep neural networks, have been highly…

图像与视频处理 · 电气工程与系统科学 2022-01-19 Xikai Yang , Yong Long , Saiprasad Ravishankar

Scene viewing is used to study attentional selection in complex but still controlled environments. One of the main observations on eye movements during scene viewing is the inhomogeneous distribution of fixation locations: While some parts…

神经元与认知 · 定量生物学 2018-11-14 Hans A. Trukenbrod , Simon Barthelmé , Felix A. Wichmann , Ralf Engbert

The nature of yield in amorphous materials under stress has yet to be fully elucidated. In particular, understanding how microscopic rearrangement gives rise to macroscopic structural and rheological signatures in disordered systems is…

软凝聚态物质 · 物理学 2020-08-17 Erin G. Teich , K. Lawrence Galloway , Paulo E. Arratia , Danielle S. Bassett

Self-organized monolayers of highly flexible \Frechet dendrons were deposited on graphite surfaces by solution casting. Scanning tunneling microscopy (STM) reveals an unprecedented variety of patterns with up to seven stable hierarchical…

介观与纳米尺度物理 · 物理学 2011-02-18 B. A. Hermann , C. Rohr , M. Balbás Gambra , A. Malecki , M. S. Malarek , E. Frey , T. Franosch

We consider the problem of estimating fold-changes in the expected value of a multivariate outcome observed with unknown sample-specific and category-specific perturbations. This challenge arises in high-throughput sequencing studies of the…

统计方法学 · 统计学 2026-04-24 David S Clausen , Sarah Teichman , Amy D Willis

Ultrasound-induced degradation of soft polymeric colloids, like microgels, as well as a controlled drug release enabled by mechanoresponsive bonds, has recently attracted considerable attention. However, most examples in the literature…

With the advent of multi-coil imaging and compressed sensing, a number of model based reconstruction algorithms have been created. They incorporate a multitude of different regularization functions based on physics, observed phenomenology,…

图像与视频处理 · 电气工程与系统科学 2023-02-03 Nicholas Dwork , Ethan M. I. Johnson , Daniel O'Connor , Jeremy W. Gordon , Adam B. Kerr , Corey A. Baron , John M. Pauly , Peder E. Z. Larson

Recent studies of the self-assembly of Langmuir monolayers have revealed novel forms of lateral molecular ordering. Such studies typically involve the use of grazing-incidence synchrotron radiation scattering, and the lateral order…

软凝聚态物质 · 物理学 2025-09-25 L. R. Muftakhova , K. V. Nikolaev , A. V. Rogachev , N. N. Novikova , B. I. Ostrovskii , S. N. Yakunin

The vast majority of the microscopy methods currently available to study biological samples require staining prior to imaging. Nevertheless, the ability to reveal specific cell structures or organelles in a label-free manner remains…

生物物理 · 物理学 2020-10-06 R. Desapogu , G. Le Marchand , R. Smith , P. Ray , E. Gillier , S. Dutertre , M. Alouini , M. Tramier , S. Huet , J. Fade

Chemical bioreactions play a significant role in many of the microfluidic devices, and their applications in biomedical science have seen substantial growth. Given that effective mixing is vital for initiating biochemical reactions in many…

流体动力学 · 物理学 2024-02-13 Ali Kheirkhah Barzoki

Combinations of spectroscopic analysis and microscopic techniques are used across many disciplines of scientific research, including material science, chemistry and biology. X-ray spectromicroscopy, in particular, is a powerful tool used…

医学物理 · 物理学 2023-10-17 Oliver Townsend , Silvia Gazzola , Sergey Dolgov , Paul Quinn

Optical investigations on the dynamics of dense suspensions are challenging due to reduced optical accessibility. Furthermore, the suspension particle image size can strongly deviate from the optimal particle image size for PIV…

流体动力学 · 物理学 2021-09-22 Sebastian Blahout , Simon R. Reinecke , Harald Kruggel-Emden , Jeanette Hussong

The evolution of the scanning modules for scanning transmission electron microscopes (STEM) has realized the possibility to generate arbitrary scan pathways, an approach currently explored to improve acquisition speed and to reduce electron…

We study the stability of filaments in equilibrium between gravity and internal as well as external pressure using the grid based AMR-code RAMSES. A homogeneous, straight cylinder below a critical line mass is marginally stable. However, if…

太阳与恒星天体物理 · 物理学 2017-01-18 Matthias Gritschneder , Stefan Heigl , Andreas Burkert

In a previous work, we have shown that a spatially localized transmembrane pH gradient, produced by acid micro-injection near the external side of cardiolipin-containing giant unilamellar vesicles, leads to the formation of tubules that…

In medical imaging, most of the image registration methods implicitly assume a one-to-one correspondence between the source and target images (i.e., diffeomorphism). However, this is not necessarily the case when dealing with pathological…

图像与视频处理 · 电气工程与系统科学 2022-02-03 Matthis Maillard , Anton François , Joan Glaunès , Isabelle Bloch , Pietro Gori

Plasmonic systems have attracted remarkable interest due to their application to the subwavelength confinement of light and the associated enhancement of light-matter interactions. However, this requires light to dwell at a given spatial…

光学 · 物理学 2020-04-22 Lizhen Lu , Emanuele Galiffi , Kun Ding , Tianyu Dong , Xikui Ma , John Pendry

The g-ratio, quantifying the comparative thickness of the myelin sheath encasing an axon, is a geometrical invariant that has high functional relevance because of its importance in determining neuronal conduction velocity. Advances in MRI…

定量方法 · 定量生物学 2020-05-28 Siawoosh Mohammadi , Martina F. Callaghan

Fluorescence spectroscopy is an image correlation technique to analyze and characterize the molecular dynamics from a sequence of fluorescence images. Many image correlation techniques have been developed for different applications [1]. But…

定量方法 · 定量生物学 2017-10-24 C. Chen , P. Paul-Gilloteaux , T. Vignaud , J. Salamero , F. Waharte