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Advances in spatial transcriptomics (ST) technologies enable systematic molecular characterization of tumor microenvironment, tumor gradients and gene regulatory networks. Cancer progression is known to vary along pathological gradients,…

To be feasible for computationally intensive applications such as parametric studies, optimization and control design, large-scale finite element analysis requires model order reduction. This is particularly true in nonlinear settings that…

计算物理 · 物理学 2015-05-22 Maciej Balajewicz , David Amsallem , Charbel Farhat

Stochastic gradient descent (SGD) is a widely adopted iterative method for optimizing differentiable objective functions. In this paper, we propose and discuss a novel approach to scale up SGD in applications involving non-convex functions…

机器学习 · 统计学 2022-10-07 Saad Mohamad , Hamad Alamri , Abdelhamid Bouchachia

This paper addresses the optimization problem of minimizing non-convex continuous functions, which is relevant in the context of high-dimensional machine learning applications characterized by over-parametrization. We analyze a randomized…

机器学习 · 计算机科学 2025-02-28 Jim Zhao , Aurelien Lucchi , Nikita Doikov

The concept of Gaussian process tomography along with nonnegative constraints is applied in the context of high-resolution image reconstruction using segmented planar detectors with few readout channels.Expanding on the concept of 2-D…

仪器与探测器 · 物理学 2020-08-26 D. Blyth , N. Mullins , E. Galyaev , J. Holmes

Stochastic gradient-based optimization is crucial to optimize neural networks. While popular approaches heuristically adapt the step size and direction by rescaling gradients, a more principled approach to improve optimizers requires…

机器学习 · 计算机科学 2023-11-01 Philipp Dahlinger , Philipp Becker , Maximilian Hüttenrauch , Gerhard Neumann

In recent years, random subspace methods have been actively studied for large-dimensional nonconvex problems. Recent subspace methods have improved theoretical guarantees such as iteration complexity and local convergence rate while…

最优化与控制 · 数学 2025-03-25 Rei Higuchi , Pierre-Louis Poirion , Akiko Takeda

We address the problem of reconstructing X-Ray tomographic images from scarce measurements by interpolating missing acquisitions using a self-supervised approach. To do so, we train shallow neural networks to combine two neighbouring…

图像与视频处理 · 电气工程与系统科学 2022-05-18 Emilien Valat , Katayoun Farrahi , Thomas Blumensath

We introduce a two-level trust-region method (TLTR) for solving unconstrained nonlinear optimization problems. Our method uses a composite iteration step, which is based on two distinct search directions. The first search direction is…

数值分析 · 数学 2024-09-10 Andrea Angino , Alena Kopaničáková , Rolf Krause

This work investigates a two-stage method for constructing projection-based reduced-order models (ROMs) of parameterized partial differential equations (PDEs). Based on established tensorial ROM methodology, the proposed approach reduces…

数值分析 · 数学 2026-04-30 Arjun Vijaywargia , Eric C. Cyr , Anthony Gruber

This paper studies stability and symmetry preserving $H^2$ optimal model reduction problems of linear systems which include linear gradient systems as a special case. The problem is formulated as a nonlinear optimization problem on the…

最优化与控制 · 数学 2018-03-13 Kazuhiro Sato , Hiroyuki Sato

Search is a key service within constraint programming systems, and it demands the restoration of previously accessed states during the exploration of a search tree. Restoration proceeds either bottom-up within the tree to roll back…

编程语言 · 计算机科学 2016-02-05 Yong Lin , Martin Henz

In this work we investigate the practicality of stochastic gradient descent and recently introduced variants with variance-reduction techniques in imaging inverse problems. Such algorithms have been shown in the machine learning literature…

最优化与控制 · 数学 2021-01-26 Junqi Tang , Karen Egiazarian , Mohammad Golbabaee , Mike Davies

Accurate reconstruction of latent environmental fields from sparse and indirect observations is a foundational challenge across scientific domains-from atmospheric science and geophysics to public health and aerospace safety. Traditional…

机器学习 · 计算机科学 2025-06-17 Kazuma Kobayashi , Samrendra Roy , Seid Koric , Diab Abueidda , Syed Bahauddin Alam

In distributed second order optimization, a standard strategy is to average many local estimates, each of which is based on a small sketch or batch of the data. However, the local estimates on each machine are typically biased, relative to…

机器学习 · 计算机科学 2020-07-06 Michał Dereziński , Burak Bartan , Mert Pilanci , Michael W. Mahoney

Reduced Order Modeling is of paramount importance for efficiently inferring high-dimensional spatio-temporal fields in parametric contexts, enabling computationally tractable parametric analyses, uncertainty quantification and control.…

机器学习 · 计算机科学 2025-02-18 Matteo Tomasetto , Jan P. Williams , Francesco Braghin , Andrea Manzoni , J. Nathan Kutz

This paper considers an explicit continuation method and the trust-region updating strategy for the unconstrained optimization problem. Moreover, in order to improve its computational efficiency and robustness, the new method uses the…

最优化与控制 · 数学 2021-02-16 Xin-long Luo , Hang Xiao , Jia-hui Lv , Sen Zhang

Compressed Sensing MRI (CS-MRI) has shown promise in reconstructing under-sampled MR images, offering the potential to reduce scan times. Classical techniques minimize a regularized least-squares cost function using an expensive iterative…

图像与视频处理 · 电气工程与系统科学 2020-07-30 Alan Q. Wang , Adrian V. Dalca , Mert R. Sabuncu

We propose a higher-order dimensionality reduction framework based on the Trace Ratio (TR) optimization problem. We establish conditions for existence and uniqueness of solutions and clarify the theoretical connection between the Trace…

数值分析 · 数学 2025-11-25 Alaeddine Zahir , Franck Dufrenois , Khalide Jbilou , Ahmed Ratnani

English: This paper concerns the image reconstruction from a few projections in Computed Tomography (CT). The main objective of this paper is to show that the problem is so ill posed that no classical method, such as analytical methods…

数据分析、统计与概率 · 物理学 2007-05-23 Ali Mohammad-Djafari