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Accurate computational identification of promoters remains a challenge as these key DNA regulatory regions have variable structures composed of functional motifs that provide gene specific initiation of transcription. In this paper we…

基因组学 · 定量生物学 2016-10-04 Victor Solovyev , Ramzan Umarov

Gene promoters are the key DNA regulatory elements positioned around the transcription start sites and are responsible for regulating gene transcription process. Various alignment-based, signal-based and content-based approaches are…

基因组学 · 定量生物学 2021-05-18 Nikita Bhandari , Satyajeet Khare , Rahee Walambe , Ketan Kotecha

Computational identification of promoters is notoriously difficult as human genes often have unique promoter sequences that provide regulation of transcription and interaction with transcription initiation complex. While there are many…

基因组学 · 定量生物学 2018-10-04 Ramzan Umarov , Hiroyuki Kuwahara , Yu Li , Xin Gao , Victor Solovyev

Locating the promoter region in DNA sequences is of paramount importance in the field of bioinformatics. This is a problem widely studied in the literature, however, not yet fully resolved. Some researchers have presented remarkable results…

机器学习 · 计算机科学 2021-12-08 Lauro Moraes , Pedro Silva , Eduardo Luz , Gladston Moreira

Background: In organisms' genomes, promoters are short DNA sequences on the upstream of structural genes, with the function of controlling genes' transcription. Promoters can be roughly divided into two classes: constitutive promoters and…

其他定量生物学 · 定量生物学 2019-02-19 Shangjie Zou

Our aim is to predict how often genic and non-genic promoters fire within a cell. We first review a parsimonious pan-genomic model for genome organization and gene regulation, where transcription rate is determined by proximity in 3D space…

生物物理 · 物理学 2024-12-04 Giuseppe Negro , Massimiliano Semeraro , Perter R Cook , Davide Marenduzzo

Most recent person re-identification approaches are based on the use of deep convolutional neural networks (CNNs). These networks, although effective in multiple tasks such as classification or object detection, tend to focus on the most…

计算机视觉与模式识别 · 计算机科学 2021-02-19 Abdallah Benzine , Mohamed El Amine Seddik , Julien Desmarais

Minimizers and convolutional neural networks (CNNs) are two quite distinct popular techniques that have both been employed to analyze categorical biological sequences. At face value, the methods seem entirely dissimilar. Minimizers use…

机器学习 · 计算机科学 2024-01-29 Yun William Yu

Human body consists of lot of cells, each cell consist of DeOxaRibo Nucleic Acid (DNA). Identifying the genes from the DNA sequences is a very difficult task. But identifying the coding regions is more complex task compared to the former.…

计算工程、金融与科学 · 计算机科学 2014-01-22 Pokkuluri Kiran Sree , Inampudi Ramesh Babu , SSSN Usha Devi N

Identifying polyps is challenging for automatic analysis of endoscopic images in computer-aided clinical support systems. Models based on convolutional networks (CNN), transformers, and their combinations have been proposed to segment…

计算机视觉与模式识别 · 计算机科学 2022-06-08 Nguyen Thanh Duc , Nguyen Thi Oanh , Nguyen Thi Thuy , Tran Minh Triet , Dinh Viet Sang

Transcription is one of the essential processes for cells to read genetic information encoded in genes, which is initiated by the binding of RNA polymerase to related promoter. Experiments have found that the nucleotide sequence of promoter…

基因组学 · 定量生物学 2015-03-13 Jingwei Li , Yunxin Zhang

A common problem in bioinformatics is related to identifying gene regulatory regions marked by relatively high frequencies of motifs, or deoxyribonucleic acid sequences that often code for transcription and enhancer proteins. Predicting…

基因组学 · 定量生物学 2021-01-22 Ethan Jacob Moyer , Anup Das

Surface defect inspection is of great importance for industrial manufacture and production. Though defect inspection methods based on deep learning have made significant progress, there are still some challenges for these methods, such as…

计算机视觉与模式识别 · 计算机科学 2023-09-25 Xiaoheng Jiang , Kaiyi Guo , Yang Lu , Feng Yan , Hao Liu , Jiale Cao , Mingliang Xu , Dacheng Tao

Convolutional neural networks (CNNs) achieved the state-of-the-art performance in medical image segmentation due to their ability to extract highly complex feature representations. However, it is argued in recent studies that traditional…

计算机视觉与模式识别 · 计算机科学 2025-03-31 Zhendi Gong , Andrew P. French , Guoping Qiu , Xin Chen

Convolutional neural networks (CNN) and Transformer have wildly succeeded in multimedia applications. However, more effort needs to be made to harmonize these two architectures effectively to satisfy speech enhancement. This paper aims to…

音频与语音处理 · 电气工程与系统科学 2023-07-31 Xinmeng Xu , Weiping Tu , Yuhong Yang

We propose introspective convolutional networks (ICN) that emphasize the importance of having convolutional neural networks empowered with generative capabilities. We employ a reclassification-by-synthesis algorithm to perform training…

计算机视觉与模式识别 · 计算机科学 2018-01-08 Long Jin , Justin Lazarow , Zhuowen Tu

Breeding by introgressive hybridization is a pivotal strategy to broaden the genetic basis of crops. Usually, the desired traits are monitored in consecutive crossing generations by marker-assisted selection, but their analyses fail in…

Gene-regulatory enhancers have been identified by many lines of evidence, including evolutionary conservation, regulatory protein binding, chromatin modifications, and DNA sequence motifs. To integrate these different approaches, we…

基因组学 · 定量生物学 2015-06-17 Genevieve D. Erwin , Rebecca M. Truty , Dennis Kostka , Katherine S. Pollard , John A. Capra

Most recent scribble-supervised segmentation methods commonly adopt a CNN framework with an encoder-decoder architecture. Despite its multiple benefits, this framework generally can only capture small-range feature dependency for the…

计算机视觉与模式识别 · 计算机科学 2024-02-06 Zihan Li , Yuan Zheng , Dandan Shan , Shuzhou Yang , Qingde Li , Beizhan Wang , Yuanting Zhang , Qingqi Hong , Dinggang Shen

Convolutional Neural Network (CNN) image classifiers are traditionally designed to have sequential convolutional layers with a single output layer. This is based on the assumption that all target classes should be treated equally and…

计算机视觉与模式识别 · 计算机科学 2017-10-06 Xinqi Zhu , Michael Bain
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