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Medical deep learning models depend heavily on domain-specific knowledge to perform well on knowledge-intensive clinical tasks. Prior work has primarily leveraged unimodal knowledge graphs, such as the Unified Medical Language System…

人工智能 · 计算机科学 2025-05-26 Xiaochen Wang , Yuan Zhong , Lingwei Zhang , Lisong Dai , Ting Wang , Fenglong Ma

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

神经元与认知 · 定量生物学 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

It is prevalent to utilize external knowledge to help machine answer questions that need background commonsense, which faces a problem that unlimited knowledge will transmit noisy and misleading information. Towards the issue of introducing…

计算与语言 · 计算机科学 2021-07-06 Luxi Xing , Yue Hu , Jing Yu , Yuqiang Xie , Wei Peng

Diabetes is a worldwide health issue affecting millions of people. Machine learning methods have shown promising results in improving diabetes prediction, particularly through the analysis of diverse data types, namely gene expression data.…

机器学习 · 计算机科学 2024-04-24 Rita T. Sousa , Heiko Paulheim

Current general-purpose large language models (LLMs) commonly exhibit knowledge hallucination and insufficient domain-specific adaptability in domain-specific tasks, limiting their effectiveness in specialized question answering scenarios.…

信息检索 · 计算机科学 2025-09-16 Mengzheng Yang , Yanfei Ren , David Osei Opoku , Ruochang Li , Peng Ren , Chunxiao Xing

Much of biomedical and healthcare data is encoded in discrete, symbolic form such as text and medical codes. There is a wealth of expert-curated biomedical domain knowledge stored in knowledge bases and ontologies, but the lack of reliable…

人工智能 · 计算机科学 2020-06-25 David Chang , Ivana Balazevic , Carl Allen , Daniel Chawla , Cynthia Brandt , Richard Andrew Taylor

We introduced a methodology to efficiently exploit natural-language expressed biomedical knowledge for repurposing existing drugs towards diseases for which they were not initially intended. Leveraging on developments in Computational…

定量方法 · 定量生物学 2014-06-17 Ruggero Gramatica , T. Di Matteo , Stefano Giorgetti , Massimo Barbiani , Dorian Bevec , Tomaso Aste

Identification of disease genes, which are a set of genes associated with a disease, plays an important role in understanding and curing diseases. In this paper, we present a biomedical knowledge graph designed specifically for this…

Knowledge graphs and large language models (LLMs) are key tools for biomedical knowledge integration and reasoning, facilitating structured organization of scientific articles and discovery of complex semantic relationships. However,…

计算与语言 · 计算机科学 2025-04-01 Yichun Feng , Jiawei Wang , Ruikun He , Lu Zhou , Yixue Li

With the wide application of electronic health records (EHR) in healthcare facilities, health event prediction with deep learning has gained more and more attention. A common feature of EHR data used for deep-learning-based predictions is…

机器学习 · 计算机科学 2021-12-17 Chang Lu , Tian Han , Yue Ning

The healthcare environment is commonly referred to as "information-rich" but also "knowledge poor". Healthcare systems collect huge amounts of data from various sources: lab reports, medical letters, logs of medical tools or programs,…

计算与语言 · 计算机科学 2024-01-22 Elena-Simona Apostol , Ciprian-Octavian Truică

The detection and normalization of diseases in biomedical texts are key biomedical natural language processing tasks. Disease names need not only be identified, but also normalized or linked to clinical taxonomies describing diseases such…

计算与语言 · 计算机科学 2020-10-27 Dhruba Pujary , Camilo Thorne , Wilker Aziz

Sparse autoencoders (SAEs) extract millions of interpretable features from a language model, but flat feature inventories aren't very useful on their own. Domain concepts get mixed with generic and weakly grounded features, while related…

人工智能 · 计算机科学 2026-04-29 John Winnicki , Abeynaya Gnanasekaran , Eric Darve

Constructing large-scaled medical knowledge graphs can significantly boost healthcare applications for medical surveillance, bring much attention from recent research. An essential step in constructing large-scale MKG is extracting…

计算机视觉与模式识别 · 计算机科学 2021-10-27 Jialun Wu , Yang Liu , Zeyu Gao , Tieliang Gong , Chunbao Wang , Chen Li

Modern distributed decision-making systems face significant challenges arising from data heterogeneity, dynamic environments, and the need for decentralized coordination. This paper introduces the Knowledge Sharing paradigm as an innovative…

分布式、并行与集群计算 · 计算机科学 2026-02-10 Rosario Napoli , Gabriele Morabito , Antonio Celesti , Massimo Villari , Maria Fazio

Traditional Online Public Access Catalogues (OPACs) are becoming less effective due to the rapid growth of scholarly literature. Conventional search methods, such as keyword indexing and Boolean queries, often fail to support efficient…

数字图书馆 · 计算机科学 2026-04-03 M. S. Rajeevan , B. Mini Devi

With the proliferation of research means and computational methodologies, published biomedical literature is growing exponentially in numbers and volume. Cancer cell lines are frequently used models in biological and medical research that…

计算与语言 · 计算机科学 2024-02-13 Ellery Smith , Rahel Paloots , Dimitris Giagkos , Michael Baudis , Kurt Stockinger

Semantic web technologies have significantly contributed with effective solutions for the problems of data integration and knowledge graph creation. However, with the rapid growth of big data in diverse domains, different interoperability…

数据库 · 计算机科学 2022-09-22 Samaneh Jozashoori , Maria-Esther Vidal

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches…

图像与视频处理 · 电气工程与系统科学 2023-05-26 Reza Shirkavand , Liang Zhan , Heng Huang , Li Shen , Paul M. Thompson

The extraction of lung lesion information from clinical and medical imaging reports is crucial for research on and clinical care of lung-related diseases. Large language models (LLMs) can be effective at interpreting unstructured text in…

计算与语言 · 计算机科学 2024-11-18 Diya Li , Asim Kadav , Aijing Gao , Rui Li , Richard Bourgon