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Genes are connected in complex networks of interactions where often the product of one gene is a transcription factor that alters the expression of another. Many of these networks are based on a few fundamental motifs leading to switches…

分子网络 · 定量生物学 2026-03-05 Zitao Yang , Rebecca J. Rousseau , Sara D. Mahdavi , Hernan G. Garcia , Rob Phillips

The design of quantum circuits is often still done manually, for instance by following certain patterns or rule of thumb. While this approach may work well for some problems, it can be a tedious task and present quite the challenge in other…

量子物理 · 物理学 2023-05-11 Leo Sünkel , Darya Martyniuk , Denny Mattern , Johannes Jung , Adrian Paschke

Linear response theory has found many applications in statistical physics. One of these is to compute minimal-work protocols that drive nonequilibrium systems between different thermodynamic states, which are useful for designing engineered…

统计力学 · 物理学 2026-01-19 Samuel. H. DAmbrosia , Adrianne Zhong , Michael R. DeWeese

We describe modeling approaches to a "network" of connected enzyme-catalyzed reactions, with added (bio)chemical processes that introduce biochemical filtering steps into the functioning of such a biocatalytic cascade. Theoretical…

分子网络 · 定量生物学 2016-12-13 Vladimir Privman

Scientific studies often require the precise calculation of derivatives. In many cases an analytical calculation is not feasible and one resorts to evaluating derivatives numerically. These are error-prone, especially for higher-order…

高能物理 - 唯象学 · 物理学 2010-05-28 Mathias Wagner , Andrea Walther , Bernd-Jochen Schaefer

For simple digital circuits, conventional method of designing circuits can easily be applied. But for complex digital circuits, the conventional method of designing circuits is not fruitfully applicable because it is time-consuming. On the…

神经与进化计算 · 计算机科学 2013-04-10 S. M. Ashik Eftekhar , Sk. Mahbub Habib , M. M. A. Hashem

We advance here an algorithm of a synthesis of an electric circuit based on prescribed quadratic Lagrangian. That is the circuit evolution equations are equivalent to the relevant Euler-Lagrange equations. The proposed synthesis is a…

应用物理 · 物理学 2021-05-11 Alexander Figotin

In various provers and deductive verification tools, logical transformations are used extensively in order to reduce a proof task into a number of simpler tasks. Logical transformations are often part of the trusted base of such tools. In…

计算机科学中的逻辑 · 计算机科学 2021-07-07 Quentin Garchery

This article exhibits a particular encoding of logic circuits into a sheaf formalism. The central result of this article is that there exists strictly more information available to a circuit designer in this setting than exists in static…

硬件体系结构 · 计算机科学 2010-08-17 Michael Robinson

Logic synthesis is a crucial phase in the circuit design process, responsible for transforming hardware description language (HDL) designs into optimized netlists. However, traditional logic synthesis methods are computationally intensive,…

Training large language models (LLMs) with synthetic reasoning data has become a popular approach to enhancing their reasoning capabilities, while a key factor influencing the effectiveness of this paradigm is the quality of the generated…

人工智能 · 计算机科学 2026-03-24 Zhuojie Yang , Wentao Wan , Keze Wang

Rule-based systems remain central in safety-critical domains but often struggle with scalability, brittleness, and goal misspecification. These limitations can lead to reward hacking and failures in formal verification, as AI systems tend…

计算机科学中的逻辑 · 计算机科学 2026-05-12 Zainab Rehan , Christian Medeiros Adriano , Sona Ghahremani , Holger Giese

Limit cycles are self-sustained, closed trajectories in phase space representing (un)-stable, periodic behavior in nonlinear dynamical systems. They underpin diverse natural phenomena, from neuronal firing patterns to engineering…

适应与自组织系统 · 物理学 2025-08-15 Sandip Saha , Suvam Pal , Dibakar Ghosh

Transform methods, like Laplace and Fourier, are frequently used for analyzing the dynamical behaviour of engineering and physical systems, based on their transfer function, and frequency response or the solutions of their corresponding…

计算机科学中的逻辑 · 计算机科学 2017-05-30 Adnan Rashid , Osman Hasan

Genetic Programming is an evolutionary algorithm that generates computer programs, or mathematical expressions, to solve complex problems. In this Guide, we demonstrate how to use Genetic Programming to develop surrogate models to mitigate…

We present new techniques for synthesizing programs through sequences of mutations. Among these are (1) a method of local scoring assigning a score to each expression in a program, allowing us to more precisely identify buggy code, (2)…

神经与进化计算 · 计算机科学 2023-01-26 Max Vistrup

Demonstrating quantum advantage using conventional quantum algorithms remains challenging on current noisy gate-based quantum computers. Automated quantum circuit synthesis via quantum machine learning has emerged as a promising solution,…

量子物理 · 物理学 2025-04-14 Shubing Xie , Aritra Sarkar , Sebastian Feld

Many natural systems exhibit cyclo-stationary behavior characterized by periodic forcing such as annual and diurnal cycles. We present a data-driven method leveraging recent advances in score-based generative modeling to construct…

混沌动力学 · 物理学 2025-09-03 Ludovico Theo Giorgini , Tobias Bischoff , Andre Noguiera Souza

Given a discrete-state continuous-time reactive system, like a digital circuit, the classical approach is to first model it as a state transition system and then prove its properties. Our contribution advocates a different approach: to…

分布式、并行与集群计算 · 计算机科学 2022-08-18 Matthias Fuegger , Christoph Lenzen , Ulrich Schmid

A central goal of evolutionary biology is to explain the origins and distribution of diversity across life. Beyond species or genetic diversity, we also observe diversity in the circuits (genetic or otherwise) underlying complex functional…

种群与进化 · 定量生物学 2018-06-06 Ali Tehrani-Saleh , Thomas LaBar , Christoph Adami