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Bilayer lipid membranes [BLMs] are an essential component of all biological systems, forming a functional barrier for cells and organelles from the surrounding environment. The lipid molecules that form membranes contain both permanent and…

生物物理 · 物理学 2015-03-17 Richard J. Bingham , Peter D. Olmsted , Stephen W. Smye

The influence of an electric field on a poorly conductive membrane such as a lipid bilayer is studied theoretically. The unbalanced electric stress created by an ionic current across a non-perfectly flat membrane gives rise to a…

软凝聚态物质 · 物理学 2009-11-07 Pierre Sens , Hervé Isambert

A mesoscopic coarse-grain model for computationally-efficient simulations of biomembranes is presented. It combines molecular dynamics simulations for the lipids, modeled as elastic chains of beads, with multiparticle collision dynamics for…

软凝聚态物质 · 物理学 2015-06-04 Mu-Jie Huang , Raymond Kapral , Alexander S. Mikhailov , Hsuan-Yi Chen

Colloids and proteins alike can bind to lipid bilayers and move laterally in these two-dimensional fluids. Inspired by proteins that generate membrane curvature, sense the underlying membrane geometry, and migrate to high curvature sites,…

A common mechanism for intracellular transport is the use of controlled deformations of the membrane to create spherical or tubular buds. While the basic physical properties of homogeneous membranes are relatively well-known, the effects of…

A phenomenological Landau elasticity for the shape, dilation, and lipid-tilt of bilayer membranes is developed. The shape mode couples with the sum of the monolayers' tilt, while the dilation mode couples with the difference of the…

软凝聚态物质 · 物理学 2009-10-31 J. -B. Fournier

We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from…

软凝聚态物质 · 物理学 2016-10-10 Andrew Callan-Jones , Marc Durand , Jean-Baptiste Fournier

The statistical physics and dynamics of double supported bilayers are studied theoretically. The main goal in designing double supported lipid bilayers is to obtain model systems of biomembranes: the upper bilayer is meant to be almost…

软凝聚态物质 · 物理学 2015-03-13 Manoel Manghi , Nicolas Destainville

For the past decade, droplet interface bilayers (DIBs) have had an increased prevalence in biomolecular and biophysical literature. However, much of the underlying physics of these platforms are poorly characterized. To further the…

Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of…

生物物理 · 物理学 2023-02-22 Carlos D. Alas , Christoph A. Haselwandter

Bilayer lipid membranes (BLMs) are an essential component of many biological systems, forming a functional barrier between the cell and the surrounding environment. When the membrane relaxes from a structural perturbation, the dynamics of…

软凝聚态物质 · 物理学 2015-07-27 R. J. Bingham , S. W. Smye , P. D. Olmsted

Field-theoretical method is proposed, that yields analytical expression for lateral pressure distribution across hydrophobic core of a bilayer lipid membrane. Lipid molecule, repelling entropicaly surrounding neighbors, is modeled as a…

软凝聚态物质 · 物理学 2007-05-23 Sergei I. Mukhin , Svetlana V. Baoukina

We have constructed a model for the kinetics of rupture of membranes under tension, applying physical principles relevant to lipid bilayers held together by hydrophobic interactions. The membrane is characterized by the bulk compressibility…

生物物理 · 物理学 2009-11-07 Luc Fournier , Bela Joos

Dynamic lateral transport of lipids, proteins, and self-assembled structures in biomembranes plays crucial roles in diverse cellular processes. In this study, we perform a coarse-grained molecular dynamics simulation on a vesicle composed…

软凝聚态物质 · 物理学 2023-11-27 Hiroaki Ito , Naofumi Shimokawa , Yuji Higuchi

In this paper, phase field models are developed for multi-component vesicle membranes with different lipid compositions and membranes with free boundary. These models are used to simulate the deformation of membranes under the elastic…

生物物理 · 物理学 2007-05-23 Xiaoqiang Wang , Qiang Du

The tensile force along a cylindrical lipid bilayer tube is proportional to the membrane's bending modulus and inversely proportional to the tube radius. We show that this relation, which is experimentally exploited to measure bending…

软凝聚态物质 · 物理学 2007-05-23 Vagelis A. Harmandaris , Markus Deserno

Consider a lipid membrane with a free exposed edge. The energy describing this membrane is quadratic in the extrinsic curvature of its geometry; that describing the edge is proportional to its length. In this note we determine the boundary…

软凝聚态物质 · 物理学 2009-11-07 R. Capovilla , J. Guven , J. A. Santiago

The eukaryotic cell membrane is connected to a dense actin rich cortex. We present FCS and STED experiments showing that dense membrane bound actin networks have severe influence on lipid phase separation. A minimal actin cortex was bound…

软凝聚态物质 · 物理学 2018-10-17 Alf Honigmann , Sina Sadeghi , Jan Keller , Stefan W. Hell , Christian Eggeling , Richard Vink

Morphological change of bilayer membrane in vivo is not a spontaneous procedure but modulated by various types of proteins in general. Most of these modulations are associated with the localization of related proteins in the crowded lipid…

定量方法 · 定量生物学 2016-06-30 Michael Mikucki , Y. C. Zhou

The interplay of membrane proteins is vital for many biological processes, such as cellular transport, cell division, and signal transduction between nerve cells. Theoretical considerations have led to the idea that the membrane itself…

软凝聚态物质 · 物理学 2016-11-28 Casper van der Wel , Afshin Vahid , Anđela Šarić , Timon Idema , Doris Heinrich , Daniela J. Kraft