相关论文: Simplified calcium signaling cascade for synaptic …

Many cells use calcium signalling to carry information from the extracellular side of the plasma membrane to targets in their interior. Since virtually all cells employ a network of biochemical reactions for Ca2+ signalling, much effort has…

Continuum models of plasticity fail to capture the richness of microstructural evolution because the continuum is a homogeneous construction. The present study shows that an alternative way is available at the mesoscale in the form of truly…

We develop a spatially explicit biophysical model of the hippocampal CA3-CA1 presynaptic bouton to study local calcium dynamics leading to vesicle fusion. A kinetic model with two calcium sensors is formulated specifically for the CA3-CA1…

NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indicates that…

Most of the calcium in the body is stored in bone. The rest is stored elsewhere, and calcium signalling is one of the most important mechanisms of information propagation in the body. Yet, many questions remain open. In this work, we…

The N-methyl-D-aspartate receptor (NMDAR) is a crucial component of synaptic transmission, and its dysfunction is implicated in many neurological diseases and psychiatric conditions. NMDAR-based short-term postsynaptic plasticity (STPP) is…

We present efficient Bayesian methods for extracting neuronal spiking information from calcium imaging data. The goal of our methods is to sample from the posterior distribution of spike trains and model parameters (baseline concentration,…

We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain. This interaction enables the astrocyte to modulate the information flow from…

Understanding how biological neural networks carry out learning using spike-based local plasticity mechanisms can lead to the development of powerful, energy-efficient, and adaptive neuromorphic processing systems. A large number of…

Recent years have witnessed an increasing interest in neuron-glia communication. This interest stems from the realization that glia participates in cognitive functions and information processing and is involved in many brain disorders and…

Calcium is an ubiquitous second messenger that triggers a plethora of key physiological responses. The events are initiated in micro- or nano-sized compartments and determined by the complex interactions with calcium-binding proteins and…

The ATP-driven Plasma Membrane Calcium pump or Ca(2+)-ATPase (PMCA) is characterized by a high affinity to calcium and a low transport rate compared to other transmembrane calcium transport proteins. It plays a crucial role for calcium…

We introduce Spike Agreement Dependent Plasticity (SADP), a biologically inspired synaptic learning rule for Spiking Neural Networks (SNNs) that relies on the agreement between pre- and post-synaptic spike trains rather than precise…

Like many other biological processes, calcium dynamics in neurons containing an endoplasmic reticulum are governed by diffusion-reaction equations on interface-separated domains. Interface conditions are typically described by systems of…

Precise spatio-temporal patterns of neuronal action potentials underly e.g. sensory representations and control of muscle activities. However, it is not known how the synaptic efficacies in the neuronal networks of the brain adapt such that…

This paper presents an extension of the BrainScaleS accelerated analog neuromorphic hardware model. The scalable neuromorphic architecture is extended by the support for multi-compartment models and non-linear dendrites. These features are…

Short-term synaptic plasticity (STP) is often regarded as a presynaptic filter of spikes, independent of postsynaptic activity. Recent experiments, however, indicate an associative STP that depends on pre- and postsynaptic coactivation. We…

The brain can learn to execute a wide variety of tasks quickly and efficiently. Nevertheless, most of the mechanisms that enable us to learn are unclear or incredibly complicated. Recently, considerable efforts have been made in…

We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabilities for the opening/closing of channels which release…

In the mammalian nervous system, various synaptic plasticity rules act, either individually or synergistically, and over wide-ranging timescales to dictate the processes that enable learning and memory formation. To mimic biological…