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Stochastic phenotype switching has been suggested to play a beneficial role in microbial populations by leading to the division of labour among cells, or ensuring that at least some of the population survives an unexpected change in…

种群与进化 · 定量生物学 2016-02-02 Andrew C. Tadrowski , Martin R. Evans , Bartlomiej Waclaw

The sedimentation process in a suspension of bacteria is the result of the competition between gravity and the intrinsic motion of the microorganisms. We perform simulations of run-and-tumble "squirmers" that move in a fluid medium,…

软凝聚态物质 · 物理学 2021-11-11 Andrea Scagliarini , Ignacio Pagonabarraga

In response to a concentration gradient of nutrient, E. coli bacterium modulates the rotational bias of flagellar motors which control its run-and-tumble motion, to migrate towards regions of high nutrient concentration. Presence of…

细胞行为 · 定量生物学 2018-04-04 Subrata Dev , Sakuntala Chatterjee

Organisms must acquire and use environmental information to guide their behaviors. However, it is unclear whether and how information quantitatively limits behavioral performance. Here, we relate information to behavioral performance in…

生物物理 · 物理学 2023-02-22 Henry H. Mattingly , Keita Kamino , Benjamin B. Machta , Thierry Emonet

The trajectories of microswimmers moving in narrow channels of widths comparable to their sizes are significantly altered when they encounter another microswimmer moving in the opposite direction. The consequence of these encounters is a…

Cell migration in vivo is often guided by chemical signals. Such chemotaxis, such as performed by immune cells migrating to a wound site, is complicated by the complex geometry inside living tissues. In this study, we extend our theoretical…

We formulate the Smoluchowski equation for a run-and-tumble particle. It includes the mean tumble rate in a chemical field, for which we derive a Markovian response theory. Using a multipole expansion and a reaction-diffusion equation for…

生物物理 · 物理学 2019-04-30 Maximilian Seyrich , Andrzej Palugniok , Holger Stark

In natural environments, solid surfaces present both opportunities and challenges for bacteria. On one hand, they serve as platforms for biofilm formation, crucial for bacterial colonization and resilience in harsh conditions. On the other…

生物物理 · 物理学 2025-07-01 Antai Tao , Guangzhe Liu , Rongjing Zhang , Junhua Yuan

Noise in transduction of chemotactic stimuli to the flagellar motor of E. coli will affect the random run-and-tumble motion of the cell and the ability to perform chemotaxis. Here we use numerical simulations to show that an intermediate…

细胞行为 · 定量生物学 2012-10-05 Marlo Flores , Thomas S. Shimuzu , Pieter Rein ten Wolde , Filipe Tostevin

The large scale behaviour of a population of cells that grow and interact through the concentration field of the chemicals they secrete is studied using dynamical renormalization group methods. The combination of the effective long-range…

细胞行为 · 定量生物学 2015-01-19 Anatolij Gelimson , Ramin Golestanian

We study methylation dynamics of the chemoreceptors as an {\sl E.coli} cell moves around in a spatially varying chemo-attractant environment. We consider attractant concentration with strong and weak spatial gradient. During the uphill and…

细胞行为 · 定量生物学 2022-01-28 Shobhan Dev Mandal , Sakuntala Chatterjee

A novel trait-structured Keller-Segel model that explores the dynamics of a migrating cell population guided by chemotaxis in response to an external ligand concentration is derived and analysed. Unlike traditional Keller-Segel models, this…

细胞行为 · 定量生物学 2025-02-27 Viktoria Freingruber , Tommaso Lorenzi , Kevin J. Painter , Mariya Ptashnyk

How systems are endowed with migration capacity is a fascinating question with implications ranging from the design of novel active systems to the control of microbial populations. Bacteria, which can be found in a variety of environments,…

生物物理 · 物理学 2017-07-03 Marc Hennes , Julien Tailleur , Gaëlle Charron , Adrian Daerr

The chemotactic pathway allows bacteria to respond and adapt to environmental changes, by tuning the tumbling and running motions that are due to clockwise and counterclockwise rotations of their flagella. The pathway is tightly regulated…

分子网络 · 定量生物学 2009-10-09 Daniela Besozzi , Paolo Cazzaniga , Matteo Dugo , Dario Pescini , Giancarlo Mauri

A common feature of biological self-organization is how active agents communicate with each other or their environment via chemical signaling. Such communications, mediated by self-generated chemical gradients, have consequences for both…

For navigation, microscopic agents such as biological cells rely on noisy sensory input. In cells performing chemotaxis, such noise arises from the stochastic binding of signaling molecules at low concentrations. Using chemotaxis of sperm…

The self-organization of microbial ecosystems involves a large variety of mechanisms, ranging from biochemical signaling to population dynamics. Among these, the role of motility regulation has been little studied, despite the importance of…

统计力学 · 物理学 2025-03-18 Alberto Dinelli , Ada Altieri , Julien Tailleur

We present a new algorithm based on a Cartesian mesh for the numerical approximation of kinetic models for chemosensitive movements set in an arbitrary geometry. We investigate the influence of the geometry on the collective behavior of…

数值分析 · 数学 2013-03-12 Francis Filbet , Chang Yang

Controlling bacterial surface adhesion and subsequent biofilm formation in fluid systems is crucial for the safety and efficacy of medical and industrial processes. Here, we theoretically examine the transport of bacteria close to surfaces,…

软凝聚态物质 · 物理学 2025-07-08 Edwina F. Yeo , Benjamin J. Walker , Philip Pearce , Mohit P. Dalwadi

Bacterial chemotaxis is controlled by the conformational changes of the receptors, in response to the change of the ambient chemical concentration. In a statistical mechanical approach, the signalling due to the conformational changes is a…

生物物理 · 物理学 2009-11-07 Yu Shi