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The bacterium Escherichia coli (E. coli) moves in its natural environment in a series of straight runs, interrupted by tumbles which cause change of direction. It performs chemotaxis towards chemo-attractants by extending the duration of…

定量方法 · 定量生物学 2010-07-12 Melissa Reneaux , Manoj Gopalakrishnan

Chemotaxis of bacterial swimmers that move in a run-and-turn pattern is well studied in uniform bulk fluid. It is primarily based on modulating the run time in dependence on the swimming direction with respect to the source of…

软凝聚态物质 · 物理学 2025-03-10 Sönke Beier , Veronika Pfeifer , Agniva Datta , Robert Großmann , Carsten Beta

Many motile cells exhibit migratory behaviors, such as chemotaxis (motion up or down a chemical gradient) or chemokinesis (when speed depends on concentration), which enable them to carry out vital functions including immune response, egg…

软凝聚态物质 · 物理学 2021-02-05 Jeffrey L. Moran , Philip M. Wheat , Nathan A. Marine , Jonathan D. Posner

Various microorganisms and some mammalian cells are able to swim in viscous fluids by performing nonreciprocal body deformations, such as rotating attached flagella or by distorting their entire body. In order to perform chemotaxis, i.e. to…

生物物理 · 物理学 2021-05-06 Benedikt Hartl , Maximilian Hübl , Gerhard Kahl , Andreas Zöttl

Chemotaxis plays a crucial role in a variety of processes in biology and ecology. Quite often it acts to improve efficiency of biological reactions. One example is the immune system signalling, where infected tissues release chemokines…

偏微分方程分析 · 数学 2020-04-15 Alexander Kiselev , Fedor Nazarov , Lenya Ryzhik , Yao Yao

Collective migration -- the directed, coordinated motion of many self-propelled agents -- is a fascinating emergent behavior exhibited by active matter that has key functional implications for biological systems. Extensive studies have…

生物物理 · 物理学 2022-06-07 Tapomoy Bhattacharjee , Daniel B. Amchin , Ricard Alert , J. A. Ott , Sujit S. Datta

Microorganisms can preferentially orient and move along gradients of a chemo-attractant (i.e., chemotax) while colonies of many microorganisms can collectively undergo complex dynamics in response to chemo-attractants that they themselves…

生物物理 · 物理学 2013-10-30 Enkeleida Lushi , Raymond E. Goldstein , Michael J. Shelley

Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to…

细胞行为 · 定量生物学 2015-12-09 Gabriele Micali , Robert G. Endres

Chemotaxis, the directional locomotion of cells towards a source of a chemical gradient, is an integral part of many biological processes - for example, bacteria motion, single-cell or multicellular organisms development, immune response,…

偏微分方程分析 · 数学 2021-03-29 Yishu Gong , Alexander Kiselev

Most of our understanding of bacterial chemotaxis comes from studies of Escherichia coli. However, recent evidence suggests significant departures from the E. coli paradigm in other bacterial species. This variation may stem from different…

细胞行为 · 定量生物学 2015-03-27 Martin Godány , Bhavin S. Khatri , Richard A. Goldstein

We study single cell E.coli chemotaxis in a spatio-temporally varying attractant environment. Modeling the attractant concentration in the form of a traveling sine wave, we measure in our simulations, the chemotactic drift velocity of the…

细胞行为 · 定量生物学 2025-06-06 Shobhan Dev Mandal , Sakuntala Chatterjee

Escherichia coli is a motile bacterium that moves up a chemoattractant gradient by performing a biased random walk composed of alternating runs and tumbles. Previous models of run and tumble chemotaxis neglect one or more features of the…

定量方法 · 定量生物学 2007-06-26 J. T. Locsei

Bacterial chemotaxis for E.coli is controlled by methylation of chemoreceptors, which in a biochemical pathway regulates the concentration of the CheY-P protein that finally controls the tumbling rate. As a consequence, the tumbling rate…

软凝聚态物质 · 物理学 2025-04-23 Manuel Mayo , Rodrigo Soto

Chemotaxis and haptotaxis have been a main theme in the macroscopic study of bacterial and cellular motility. In this work we investigate the influence these processes have on the shape and motility of fast migrating cells. We note that…

细胞行为 · 定量生物学 2016-12-08 Aaron Brunk , Niklas Kolbe , Nikolaos Sfakianakis

Collective cell migration in response to a chemical cue occurs in many biological processes such as morphogenesis and cancer metastasis. Clusters of migratory cells in these systems are capable of responding to gradients of less than 1%…

生物物理 · 物理学 2016-08-24 Julien Varennes , Bumsoo Han , Andrew Mugler

Bacterial chemotaxis systems are as diverse as the environments that bacteria inhabit, but how much environmental variation can cells tolerate with a single system? Diversification of a single chemotaxis system could serve as an…

E. coli chemotactic motion in the presence of a chemoattractant field has been extensively studied using wet laboratory experiments, stochastic computational models as well as partial differential equation-based models (PDEs). The most…

Experiments have recently shown the feasibility of utilising bacteria as micro-scale robotic devices, with special attention paid to the development of bacteria-driven micro-swimmers taking advantage of built-in actuation and sensing…

软凝聚态物质 · 物理学 2019-02-14 Christian Esparza Lopez , Albane Thery , Eric Lauga

Adaptation of the chemotaxis sensory pathway of the bacterium Escherichia coli is integral for detecting chemicals over a wide range of background concentrations, ultimately allowing cells to swim towards sources of attractant and away from…

细胞行为 · 定量生物学 2015-05-18 Diana Clausznitzer , Olga Oleksiuk , Linda Lovdok , Victor Sourjik , Robert G. Endres

Living cells are capable of interacting with their environments in a variety of ways, including cell signalling, adhesion, and directed motion. These behaviours are often mediated by receptor molecules embedded in the cell membrane, which…

生物物理 · 物理学 2023-10-17 Hannah Sleath , Bortolo Mognetti , Yuval Elani , Lorenzo Di Michele