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As the COVID-19 pandemic progresses, researchers are reporting findings of randomized trials comparing standard care with care augmented by experimental drugs. The trials have small sample sizes, so estimates of treatment effects are…

计量经济学 · 经济学 2020-06-02 Charles F. Manski , Aleksey Tetenov

Unbiased and consistent variance estimators generally do not exist for design-based treatment effect estimators because experimenters never observe more than one potential outcome for any unit. The problem is exacerbated by interference and…

统计方法学 · 统计学 2024-07-04 Christopher Harshaw , Joel A. Middleton , Fredrik Sävje

Policymakers in resource-constrained settings require experimental designs that satisfy strict budget limits while ensuring precise estimation of treatment effects. We propose a framework that applies a dependent randomized rounding…

机器学习 · 统计学 2025-06-17 Khurram Yamin , Edward Kennedy , Bryan Wilder

Mixed-effect models are very popular for analyzing data with a hierarchical structure, e.g. repeated observations within subjects in a longitudinal design, patients nested within centers in a multicenter design. However, recently, due to…

统计方法学 · 统计学 2019-05-09 Abhik Ghosh , Magne Thoresen

We systematically investigate issues due to mis-specification that arise in estimating causal effects when (treatment) interference is informed by a network available pre-intervention, i.e., in situations where the outcome of a unit may…

统计方法学 · 统计学 2018-10-22 Vishesh Karwa , Edoardo M. Airoldi

Clinical trials usually target average treatment effects, but treatment decisions are made for individuals. This tension motivates a common criticism of evidence-based medicine: a treatment that is beneficial on average may be inappropriate…

应用统计 · 统计学 2026-05-29 Zach Shahn , Mats Stensrud

This paper considers how to classify the effects of interventions in causal models for outcomes and exposures observed over time. First, we demonstrate the limitations of the most common uses of potential outcomes and causal directed…

统计方法学 · 统计学 2026-05-29 Russell Steele , Naftali Weinberger , Tess Baker , Ian Shrier

We define causal estimands for experiments on single time series, extending the potential outcome framework to dealing with temporal data. Our approach allows the estimation of some of these estimands and exact randomization based p-values…

统计方法学 · 统计学 2020-02-17 Iavor Bojinov , Neil Shephard

No man is an island, as individuals interact and influence one another daily in our society. When social influence takes place in experiments on a population of interconnected individuals, the treatment on a unit may affect the outcomes of…

统计方法学 · 统计学 2017-08-30 Edward K. Kao

Assessing the causal effects of interventions on ordinal outcomes is an important objective of many educational and behavioral studies. Under the potential outcomes framework, we can define causal effects as comparisons between the…

统计方法学 · 统计学 2018-04-06 Jiannan Lu , Peng Ding , Tirthankar Dasgupta

We study sequential experiments where sampling is costly and a decision-maker aims to determine the best treatment for full scale implementation by (1) adaptively allocating units between two possible treatments, and (2) stopping the…

计量经济学 · 经济学 2025-05-06 Karun Adusumilli

Consider the case that one observes a single time-series, where at each time t one observes a data record O(t) involving treatment nodes A(t), possible covariates L(t) and an outcome node Y(t). The data record at time t carries information…

统计理论 · 数学 2021-02-04 Mark J. van der Laan , Ivana Malenica

Causal effect moderation investigates how the effect of interventions (or treatments) on outcome variables changes based on observed characteristics of individuals, known as potential effect moderators. With advances in data collection,…

统计方法学 · 统计学 2024-11-26 Soham Bakshi , Walter Dempsey , Snigdha Panigrahi

Randomized experiments is a key part of product development in the tech industry. It is often necessary to run programs of exclusive experiments, i.e., experiments that cannot be run on the same units during the same time. These programs…

统计方法学 · 统计学 2020-12-21 Mårten Schultzberg , Oskar Kjellin , Johan Rydberg

In this paper, we study the design and analysis of experiments conducted on a set of units over multiple time periods where the starting time of the treatment may vary by unit. The design problem involves selecting an initial treatment time…

计量经济学 · 经济学 2023-09-27 Ruoxuan Xiong , Susan Athey , Mohsen Bayati , Guido Imbens

Trial engagement effects are effects of trial participation on the outcome that are not mediated by treatment assignment. Most work on extending (generalizing or transporting) causal inferences from a randomized trial to a target population…

统计方法学 · 统计学 2024-07-23 Lawson Ung , Tyler J. VanderWeele , Issa J. Dahabreh

Paired cluster-randomized experiments (pCRTs) are common across many disciplines because there is often natural clustering of individuals, and paired randomization can help balance baseline covariates to improve experimental precision.…

统计方法学 · 统计学 2024-07-03 Charlotte Z. Mann , Adam C. Sales , Johann A. Gagnon-Bartsch

The clustered observational study (COS) design is the observational study counterpart to the clustered randomized trial. In a COS, a treatment is assigned to intact groups, and all units within the group are exposed to the treatment.…

统计方法学 · 统计学 2022-06-22 Ting Ye , Ted Westling , Lindsay Page , Luke Keele

We consider the problem of evaluating designs for a two-arm randomized experiment with an incidence (binary) outcome under a nonparametric general response model. Our two main results are that the priori pair matching design of Greevy et…

统计方法学 · 统计学 2022-09-02 Adam Kapelner , Abba M. Krieger , David Azriel

Understanding treatment effect heterogeneity has become an increasingly popular task in various fields, as it helps design personalized advertisements in e-commerce or targeted treatment in biomedical studies. However, most of the existing…

统计方法学 · 统计学 2024-07-12 Waverly Wei , Xinwei Ma , Jingshen Wang
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