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Reactive synthesis is an automatic way to translate a human intention expressed in some logic into a system of some kind. This thesis has two parts, devoted to logic and to systems. In Part I, we develop two new approaches to CTL*…

计算机科学中的逻辑 · 计算机科学 2018-08-29 Ayrat Khalimov

In contrast to the natural capabilities of humans to learn new tasks in a sequential fashion, neural networks are known to suffer from catastrophic forgetting, where the model's performances on old tasks drop dramatically after being…

机器学习 · 计算机科学 2023-04-03 Sanghwan Kim , Lorenzo Noci , Antonio Orvieto , Thomas Hofmann

The potential of synthetic biology techniques for designing complex cellular circuits able to solve complicated computations opens a whole domain of exploration, beyond experiments and theory. Such cellular circuits could be used to carry…

神经元与认知 · 定量生物学 2013-10-21 Luís F. Seoane , Ricard V. Solé

We analyze in detail the subtle yet critical differences between the structural controllability and observability of the triplet $(A,B,C)$ in the two cases that this is viewed as a linear dynamical network of interconnected nodes or as a a…

动力系统 · 数学 2019-01-18 Francesco Lo Iudice , Francesco Sorrentino , Franco Garofalo

Cell adhesion complexes (CACs), which are activated by ligand binding, play key roles in many cellular functions ranging from cell cycle regulation to mediation of cell extracellular matrix adhesion. Inspired by single molecule pulling…

生物大分子 · 定量生物学 2018-04-04 Ngo Min Toan , D. Thirumalai

Abstraction is a key verification technique to improve scalability. However, its use for neural networks is so far extremely limited. Previous approaches for abstracting classification networks replace several neurons with one of them that…

计算机科学中的逻辑 · 计算机科学 2023-07-21 Calvin Chau , Jan Křetínský , Stefanie Mohr

Symmetry properties of the evolution equation and the state to be controlled are shown to determine the basic features of the linear control of unstable orbits. In particular, the selection of control parameters and their minimal number are…

chao-dyn · 物理学 2009-10-30 R. O. Grigoriev , M. C. Cross

The need for more transparency of the decision-making processes in artificial neural networks steadily increases driven by their applications in safety critical and ethically challenging domains such as autonomous driving or medical…

神经与进化计算 · 计算机科学 2020-05-12 Richard Meyes , Constantin Waubert de Puiseau , Andres Posada-Moreno , Tobias Meisen

The life of the modern world essentially depends on the work of the large artificial homogeneous networks, such as wired and wireless communication systems, networks of roads and pipelines. The support of their effective continuous…

最优化与控制 · 数学 2017-01-25 Dmitry Yu. Ignatov , Alexander N. Filippov , Andrey D. Ignatov , Xuecang Zhang

Self-assembly is ubiquitous in nature, particularly in biology, where it underlies the formation of protein quaternary structure and protein aggregation. Quaternary structure assembles deterministically and performs a wide range of…

新兴技术 · 计算机科学 2016-04-27 S. Tesoro , S. E. Ahnert

In recent years self organised critical neuronal models have provided insights regarding the origin of the experimentally observed avalanching behaviour of neuronal systems. It has been shown that dynamical synapses, as a form of short-term…

适应与自组织系统 · 物理学 2018-03-28 L. Michiels van Kessenich , M. Luković , L. de Arcangelis , H. J. Herrmann

Autophagy is a conserved biological stress response in mammalian cells that is responsible for clearing damaged proteins and organelles from the cytoplasm and recycling their contents via the lysosomal pathway. In cases of mild stress,…

分子网络 · 定量生物学 2015-05-11 I. Tavassoly , J. Parmar , A. N. Shajahan-Haq , R. Clarke , W. T. Baumann , J. J. Tyson

A perturbative method is developed for calculating the effects of recurrent synaptic interactions between neurons embedded in a network. A series expansion is constructed that converges for networks with noisy membrane potential and weak…

无序系统与神经网络 · 物理学 2009-11-10 Patrick D. Roberts

Cells are regulated by networks of controllers having many targets, and targets affected by many controllers, but these "many-to-many" combinatorial control systems are poorly understood. Here we analyze distinct cellular networks…

Dissipation can serve as a powerful resource for controlling the behavior of open quantum systems.Recently there has been a surge of interest in the influence of dissipative coupling on large quantum systems and, more specifically, how…

量子气体 · 物理学 2019-05-22 Samantha Lapp , Jackson Ang'ong'a , Fangzhao Alex An , Bryce Gadway

Complex networks have been shown to be robust against random structural perturbations, but vulnerable against targeted attacks. Robustness analysis usually simulates the removal of individual or sets of nodes, followed by the assessment of…

分子网络 · 定量生物学 2012-11-13 Oriol Güell , Francesc Sagués , Georg Basler , Zoran Nikoloski , M. Ángeles Serrano

In the scope of discrete finite-state models of interacting components, we present a novel algorithm for identifying sets of local states of components whose activity is necessary for the reachability of a given local state. If all the…

系统与控制 · 计算机科学 2013-07-15 Loïc Paulevé , Geoffroy Andrieux , Heinz Koeppl

We study the generic limit sets of one-dimensional cellular automata, which intuitively capture their asymptotic dynamics while discarding transient phenomena. As our main results, we characterize the automata whose generic limit set is a…

动力系统 · 数学 2021-08-31 Ilkka Törmä

We present an automated method to track and identify neurons in C. elegans, called "fast Deep Learning Correspondence" or fDLC, based on the transformer network architecture. The model is trained once on empirically derived synthetic data…

定量方法 · 定量生物学 2021-07-16 Xinwei Yu , Matthew S. Creamer , Francesco Randi , Anuj K. Sharma , Scott W. Linderman , Andrew M. Leifer

The initiation of directional cell motion requires symmetry breaking that can happen both with or without external stimuli. During cell crawling, forces generated by the cytoskeleton and their transmission through mechanosensitive adhesions…

细胞行为 · 定量生物学 2023-06-02 Yuzhu Chen , David Saintillan , Padmini Rangamani