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Linkage maps are used to identify the location of genes responsible for traits and diseases. New sequencing techniques have created opportunities to substantially increase the density of genetic markers. Such revolutionary advances in…

应用统计 · 统计学 2018-04-04 Pariya Behrouzi , Ernst C. Wit

We study isospectrality for mixed Dirichlet-Neumann boundary conditions, and extend the previously derived graph-theoretic formulation of the transplantation method. Led by the theory of Brownian motion, we introduce vertex-colored and…

谱理论 · 数学 2015-04-14 Peter Herbrich

Phylogenetic networks generalize phylogenetic trees, and have been introduced in order to describe evolution in the case of transfer of genetic material between coexisting species. There are many classes of phylogenetic networks, which can…

组合数学 · 数学 2020-03-13 Mathilde Bouvel , Philippe Gambette , Marefatollah Mansouri

Motivation: Alignment-free distance and similarity functions (AF functions, for short) are a well established alternative to two and multiple sequence alignments for many genomic, metagenomic and epigenomic tasks. Due to data-intensive…

分布式、并行与集群计算 · 计算机科学 2021-10-26 Umberto Ferraro Petrillo , Francesco Palini , Giuseppe Cattaneo , Raffaele Giancarlo

The total-evidence approach to divergence-time dating uses molecular and morphological data from extant and fossil species to infer phylogenetic relationships, species divergence times, and macroevolutionary parameters in a single coherent…

种群与进化 · 定量生物学 2017-01-25 Alexandra Gavryushkina , Tracy A. Heath , Daniel T. Ksepka , Tanja Stadler , David Welch , Alexei J. Drummond

Rooted binary perfect phylogenies provide a generalization of rooted binary unlabeled trees in which each leaf is assigned a positive integer value that corresponds in a biological setting to the count of the number of indistinguishable…

种群与进化 · 定量生物学 2024-10-22 Chloe E. Shiff , Noah A. Rosenberg

Index structures are a building block of query processing and computer science in general. Since the dawn of computer technology there have been index structures. And since then, a myriad of index structures are being invented and published…

数据库 · 计算机科学 2021-09-17 Jens Dittrich , Joris Nix , Christian Schön

Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…

种群与进化 · 定量生物学 2026-04-28 Aleksandr Koshkarov , Nadia Tahiri

Rooted phylogenetic networks are used to describe evolutionary histories that contain non-treelike evolutionary events such as hybridization and horizontal gene transfer. In some cases, such histories can be described by a phylogenetic…

种群与进化 · 定量生物学 2016-10-03 Laura Jetten , Leo van Iersel

Thread-like structures are pervasive across scales, from polymeric proteins to root systems to galaxy filaments, and their characteristics can be readily investigated in the network formalism. Yet, network links usually represent only parts…

数据结构与算法 · 计算机科学 2017-06-01 David Breuer , Zoran Nikoloski

The recent advances in sequencing technologies enables the assembly of individual genomes to the reference quality. How to integrate multiple genomes from the same species and to make the integrated representation accessible to biologists…

基因组学 · 定量生物学 2020-03-16 Heng Li , Xiaowen Feng , Chong Chu

Horizontal gene transfer events partition a gene tree $T$ and thus, its leaf set into subsets of genes whose evolutionary history is described by speciation and duplication events alone. Indirect phylogenetic methods can be used to infer…

离散数学 · 计算机科学 2021-12-02 David Schaller , Marc Hellmuth , Peter F. Stadler

A large class of phylogenetic networks can be obtained from trees by the addition of horizontal edges between the tree edges. These networks are called tree based networks. Reticulation-visible networks and child-sibling networks are all…

种群与进化 · 定量生物学 2015-09-09 Louxin Zhang

The de novo assembly of large, complex genomes is a significant challenge with currently available DNA sequencing technology. While many de novo assembly software packages are available, comparatively little attention has been paid to…

基因组学 · 定量生物学 2013-07-31 Jared T. Simpson

We propose a new approach to interactive full-image semantic segmentation which enables quickly collecting training data for new datasets with previously unseen semantic classes (A demo is available at https://youtu.be/yUk8D5gEX-o). We…

计算机视觉与模式识别 · 计算机科学 2020-07-17 Mykhaylo Andriluka , Stefano Pellegrini , Stefan Popov , Vittorio Ferrari

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

种群与进化 · 定量生物学 2022-07-27 Brandon Legried , Sebastien Roch

Phylogenetic inference, grounded in molecular evolution models, is essential for understanding the evolutionary relationships in biological data. Accounting for the uncertainty of phylogenetic tree variables, which include tree topologies…

机器学习 · 计算机科学 2023-12-04 Takahiro Mimori , Michiaki Hamada

We propose Dirichlet Process mixtures of Generalized Linear Models (DP-GLM), a new method of nonparametric regression that accommodates continuous and categorical inputs, and responses that can be modeled by a generalized linear model. We…

机器学习 · 统计学 2010-07-16 Lauren A. Hannah , David M. Blei , Warren B. Powell

In this work, we translate at the level of decorated trees some of the crucial arguments which have been used in arXiv:2112.10739 for proposing a diagram-free approach for the convergence of the model in Regularity Structures. This allows…

概率论 · 数学 2023-10-05 Yvain Bruned , Usama Nadeem

In this paper we propose a nonparametric graphical test based on optimal matching, for assessing the equality of multiple unknown multivariate probability distributions. Our procedure pools the data from the different classes to create a…