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Cerebral perfusion plays a crucial role in maintaining brain function and is tightly coupled with neuronal activity. While previous studies have examined cerebral perfusion trajectories across development and aging, precise characterization…

神经元与认知 · 定量生物学 2025-02-13 Xinglin Zeng , Yiran Li , Lin Hua , Ruoxi Lu , Lucas Lemos Franco , Peter Kochunov , Shuo Chen , John A Detre , Ze Wang

Learning requires the traversal of inherently distinct cognitive states to produce behavioral adaptation. Yet, tools to explicitly measure these states with non-invasive imaging -- and to assess their dynamics during learning -- remain…

Mammalian brains span about 4 orders of magnitude in cortical volume and have to operate in different environments that require diverse behavioral skills. Despite these geometric and behavioral diversities, the examination of cerebral…

神经元与认知 · 定量生物学 2014-05-19 Jan Karbowski

The cortical magnification matrix M is introduced founded on a notion similar to that of the scalar cortical magnification factor M. Unlike M, this matrix is suitable to describe anisotropy in cortical magnification, which is of particular…

神经元与认知 · 定量生物学 2012-11-01 Markus A. Dahlem , Jan Tusch

Our knowledge of the organisation of the human brain at the population-level is yet to translate into power to predict functional differences at the individual-level, limiting clinical applications, and casting doubt on the generalisability…

Brain imaging has allowed neuroscientists to analyze brain morphology in genetic and neurodevelopmental disorders, such as Down syndrome, pinpointing regions of interest to unravel the neuroanatomical underpinnings of cognitive impairment…

计算机视觉与模式识别 · 计算机科学 2024-09-23 Jordi Malé , Juan Fortea , Mateus Rozalem Aranha , Yann Heuzé , Neus Martínez-Abadías , Xavier Sevillano

A fundamental understanding of the network architecture of the brain is necessary for the further development of theories explicating circuit function. Perhaps as a derivative of its initial application to abstract informational systems,…

神经元与认知 · 定量生物学 2018-07-13 Jennifer Stiso , Danielle Bassett

Cellular elastomeric metamaterials are interesting for various applications, e.g. soft robotics, as they may exhibit multiple microstructural pattern transformations, each with its characteristic mechanical behavior. Numerical literature…

软凝聚态物质 · 物理学 2020-05-13 S. Maraghechi , J. P. M. Hoefnagels , R. H. J. Peerlings , O. Rokoš , M. G. D. Geers

Dynamical effects on healthy brains and brains affected by tumor are investigated via numerical simulations. The brains are modeled as multilayer networks consisting of neuronal oscillators, whose connectivities are extracted from Magnetic…

适应与自组织系统 · 物理学 2021-02-03 I. Koulierakis , D. A. Verganelakis , I. Omelchenko , A. Zakharova , E. Schoell , A. Provata

Backpropagation-optimized artificial neural networks, while precise, lack robustness, leading to unforeseen behaviors that affect their safety. Biological neural systems do solve some of these issues already. Unlike artificial models,…

神经与进化计算 · 计算机科学 2025-02-04 Konstantin Holzhausen , Mia Merlid , Håkon Olav Torvik , Anders Malthe-Sørenssen , Mikkel Elle Lepperød

Studying shape changing thick surfaces induced by differential growth helps us understand morphogenesis in biology and offers opportunities for device design. While ideal 2D differential growth maps have been well studied for both isotropic…

生物物理 · 物理学 2026-02-25 Wan Yee Yau , Carl D. Modes

A central idea in understanding brains and building artificial intelligence is that structure determines function. Yet, how the brain's complex structure arises from a limited set of genetic instructions remains a key question. The ultra…

神经元与认知 · 定量生物学 2026-01-28 Xingyu Liu , Yubin Li , Guozhang Chen

The formation of microparticles requires the bending of the plasma membrane away from the cytosol. The capcity of the cell membrane to form a microparticle, and the rate of membrane deformation, are controlled by multiple factors, including…

软凝聚态物质 · 物理学 2024-02-13 Arijit Mahapatra , Sage A. Malingen , Padmini Rangamani

Accurate diagnosis of psychiatric disorders plays a critical role in improving the quality of life for patients and potentially supports the development of new treatments. Many studies have been conducted on machine learning techniques that…

机器学习 · 统计学 2019-04-15 Takashi Matsubara , Tetsuo Tashiro , Kuniaki Uehara

Understanding human fetal neurodevelopment is of great clinical importance as abnormal development is linked to adverse neuropsychiatric outcomes after birth. Recent advances in functional Magnetic Resonance Imaging (fMRI) have provided new…

图像与视频处理 · 电气工程与系统科学 2019-06-11 Xiangrui Li , Jasmine Hect , Moriah Thomason , Dongxiao Zhu

The growth of several biological tissues is known to be controlled in part by local geometrical features, such as the curvature of the tissue interface. This control leads to changes in tissue shape that in turn can affect the tissue's…

组织与器官 · 定量生物学 2016-12-01 Almie Alias , Pascal R Buenzli

Neuronal circuits of the cerebral cortex are the structural basis of mammalian cognition. The same qualitative components and connectivity motifs are repeated across functionally specialized cortical areas and mammalian species, suggesting…

神经元与认知 · 定量生物学 2025-07-04 Arno Granier , Katharina A Wilmes , Mihai A Petrovici , Walter Senn

The functioning of an organ such as the brain emerges from interactions between its constituent parts. Further, this interaction is not immutable in time but rather unfolds in a succession of patterns, thereby allowing the brain to adapt to…

神经元与认知 · 定量生物学 2021-06-02 Emmanuelle Tognoli , Daniela Benites , J. A. Scott Kelso

What role does phenotypic complexity play in the systems-level function of an embodied agent? The organismal phenotype is a topologically complex structure that interacts with a genotype, developmental physics, and an informational…

神经元与认知 · 定量生物学 2022-08-15 Bradly Alicea , Jesse Parent

Numerous mathematical models have emerged in the medical literature over the past two decades attempting to characterize the pressure and volume dynamics the central nervous system compartment. These models have been used to study he…

数值分析 · 数学 2025-10-20 James M. Drake , Sivabal Sivaloganathan , Guiseppe Tenti