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In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficient long time. However, one can explicitly assume that an unknown proportion of the population under…

统计方法学 · 统计学 2014-05-15 Vincent Bremhorst , Philippe Lambert

In this article, we study nonparametric inference for a covariate-adjusted regression function. This parameter captures the average association between a continuous exposure and an outcome after adjusting for other covariates. In…

统计方法学 · 统计学 2023-12-18 Kenta Takatsu , Ted Westling

We provide precise conditions for nonparametric identification of causal effects by high-frequency event study regressions, which have been used widely in the recent macroeconomics, financial economics and political economy literatures. The…

计量经济学 · 经济学 2025-07-24 Alessandro Casini , Adam McCloskey

Environmental epidemiologists are increasingly interested in establishing causality between exposures and health outcomes. A popular model for causal inference is the Rubin Causal Model (RCM), which typically seeks to estimate the average…

应用统计 · 统计学 2021-01-26 Keith W. Zirkle , Marie-Abele Bind , Jenise L. Swall , David C. Wheeler

In the first stage of a two-stage study, the researcher uses a statistical model to impute the unobserved exposures. In the second stage, imputed exposures serve as covariates in epidemiological models. Imputation error in the first stage…

应用统计 · 统计学 2021-07-19 Ron Sarafian , Itai Kloog , Jonathan D. Rosenblatt

Long-term behavioral and health risk factors constitute a primary focus of research on the etiology of chronic diseases. Yet, identifying critical time-windows during which risk factors have the strongest impact on disease risk is…

统计方法学 · 统计学 2022-01-14 Maude Wagner , Francine Grodstein , Karen Leffondre , Cécilia Samieri , Cécile Proust-Lima

A novel predictive modeling framework for the spread of infectious diseases using high dimensional partial differential equations is developed and implemented. A scalar function representing the infected population is defined on a…

种群与进化 · 定量生物学 2020-07-06 Sashikumaar Ganesan , Deepak Subramani

Having a precise knowledge of the dispersal ability of a population in a heterogeneous environment is of critical importance in agroecology and conservation biology as it can provide management tools to limit the effects of pests or to…

种群与进化 · 定量生物学 2015-03-19 L. Roques , E. Walker , P. Franck , S. Soubeyrand , E. K. Klein

We present a novel model to estimate biological effects caused by artificial radiation exposure, Whack-a-mole (WAM) model. It is important to take account of the recovery effects during the time course of the cellular reactions. The…

We study the problem of efficiently estimating the effect of an intervention on a single variable (atomic interventions) using observational samples in a causal Bayesian network. Our goal is to give algorithms that are efficient in both…

机器学习 · 计算机科学 2020-08-07 Arnab Bhattacharyya , Sutanu Gayen , Saravanan Kandasamy , Ashwin Maran , N. V. Vinodchandran

Composite endpoints are commonly used with an anticipation that clinically relevant endpoints as a whole would yield meaningful treatment benefits. The win ratio is a rank-based statistic to summarize composite endpoints, allowing…

统计方法学 · 统计学 2022-12-14 Di Zhang , Stephen R. Wisniewski , Jong-Hyeon Jeong

Many trials are designed to collect outcomes at or around pre-specified times after randomization. If there is variability in the times when participants are actually assessed, this can pose a challenge to learning the effect of treatment,…

统计方法学 · 统计学 2024-10-28 Bonnie B. Smith , Yujing Gao , Shu Yang , Ravi Varadhan , Andrea J. Apter , Daniel O. Scharfstein

A predictive model makes outcome predictions based on some given features, i.e., it estimates the conditional probability of the outcome given a feature vector. In general, a predictive model cannot estimate the causal effect of a feature…

机器学习 · 计算机科学 2023-04-11 Jiuyong Li , Lin Liu , Ziqi Xu , Ha Xuan Tran , Thuc Duy Le , Jixue Liu

We present a data-driven framework for reachability analysis of nonlinear dynamical systems that requires no explicit model. A denoising diffusion probabilistic model learns the time-evolving state distribution of a dynamical system from…

系统与控制 · 电气工程与系统科学 2026-04-02 Yanliang Huang , Peng Xie , Wenyuan Wu , Zhuoqi Zeng , Amr Alanwar

Inferring causal effects from an observational study is challenging because participants are not randomized to treatment. Observational studies in infectious disease research present the additional challenge that one participant's treatment…

统计方法学 · 统计学 2020-12-25 Brian G. Barkley , Michael G. Hudgens , John D. Clemens , Mohammad Ali , Michael E. Emch

The dynamics of contact networks and epidemics of infectious diseases often occur on comparable time scales. Ignoring one of these time scales may provide an incomplete understanding of the population dynamics of the infection process. We…

种群与进化 · 定量生物学 2021-02-09 Luis E C Rocha , Naoki Masuda

While machine learning is rapidly being developed and deployed in health settings such as influenza prediction, there are critical challenges in using data from one environment in another due to variability in features; even within disease…

机器学习 · 统计学 2020-03-10 Vishwali Mhasawade , Nabeel Abdur Rehman , Rumi Chunara

Interference arises when an individual's potential outcome depends on the individual treatment level, but also on the treatment level of others. A common assumption in the causal inference literature in the presence of interference is…

统计方法学 · 统计学 2018-05-15 Georgia Papadogeorgou , Fabrizia Mealli , Corwin M. Zigler

We consider a trait-structured population subject to mutation, birth and competition of logistic type, where the number of coexisting types may fluctuate. Applying a limit of rare mutations to this population while keeping the population…

概率论 · 数学 2011-12-05 Nicolas Champagnat , Amaury Lambert

Extreme natural hazards are increasing in frequency and intensity. These natural changes in our environment, combined with man-made pollution, have substantial economic, social and health impacts globally. The impact of the environment on…

统计方法学 · 统计学 2024-03-25 Aiden Price , Kerrie Mengersen , Michael Rigby , Paula Fiévez