相关论文: OPENMENDEL: A Cooperative Programming Project for …

Understanding how genetic variants influence cellular-level processes is an important step towards understanding how they influence important organismal-level traits, or "phenotypes", including human disease susceptibility. To this end…

Reward Modeling is critical in evaluating and improving the generation of Large Language Models (LLMs). While numerous recent works have shown its feasibility in improving safety, helpfulness, reasoning, and instruction-following ability,…

Generative models have demonstrated remarkable potential in time series analysis tasks, like synthesis, forecasting, imputation, etc. However, offering limited coverage for generative models, existing time series libraries are mainly…

Sampling algorithms, hypergraph degree sequences, and polytopes play a crucial role in statistical analysis of network data. This article offers a brief overview of open problems in this area of discrete mathematics from the point of view…

In the ever-changing realm of research software development, it is crucial for the scientific community to grasp current trends to identify gaps that can potentially hinder scientific progress. The adherence to the FAIR (Findable,…

Identifying disease-associated genes enables the development of precision medicine and the understanding of biological processes. Genome-wide association studies (GWAS), gene expression data, biological pathway analysis, and protein network…

With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches.…

In order to associate complex traits with genetic polymorphisms, genome-wide association studies process huge datasets involving tens of thousands of individuals genotyped for millions of polymorphisms. When handling these datasets, which…

Drug discovery is a complex process that involves multiple stages and tasks. However, existing molecular generative models can only tackle some of these tasks. We present Generalist Molecular generative model (GenMol), a versatile framework…

The reproducibility and transparency of large language models are crucial for advancing open research, ensuring the trustworthiness of results, and enabling investigations into data and model biases, as well as potential risks. To this end,…

Identifying similar documents within extensive volumes of data poses a significant challenge. To tackle this issue, researchers have developed a variety of effective distributed computing techniques. With the advancement of computing power…

Many sciences have made significant breakthroughs by adopting online tools that help organize, structure and mine information that is too detailed to be printed in journals. In this paper, we introduce OpenML, a place for machine learning…

Deep neural networks (DNNs) face significant challenges when deployed on resource-constrained extreme edge devices due to their computational and data-intensive nature. While standalone accelerators tailored for specific application…

Intelligent assistive technologies are increasingly recognized as critical daily-use enablers for people with disabilities and age-related functional decline. Longitudinal studies, curation of quality datasets, live monitoring in activities…

Genome-wide association studies(GWAS) have proven to be highly useful in revealing the genetic basis of complex diseases. At present, most GWAS are studies of a particular single disease diagnosis against controls. However, in practice, an…

General Effect Modelling (GEM) is an umbrella over different methods that utilise effects in the analyses of data with multiple design variables and multivariate responses. To demonstrate the methodology, we here use GEM in gene expression…

This paper provides a global picture about the deployment of networked processing services for genomic data sets. Many current research make an extensive use genomic data, which are massive and rapidly increasing over time. They are…

Over the last several decades, there has been rapid growth in the number and scope of agricultural genetics, genomics and breeding (GGB) databases and resources. The AgBioData Consortium (https://www.agbiodata.org/) currently represents 44…

This work describes the setup of an advanced technical infrastructure for collaborative software development (CDE) in large, distributed projects based on GitLab. We present its customization and extension, additional features and processes…

Publicly available data from open sources (e.g., United States Census Bureau (Census), World Health Organization (WHO), Intergovernmental Panel on Climate Change (IPCC)) are vital resources for policy makers, students and researchers across…