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Clinical trials often collect data on multiple outcomes, such as overall survival (OS), progression-free survival (PFS), and response to treatment (RT). In most cases, however, study designs only use primary outcome data for interim and…

应用统计 · 统计学 2026-04-28 Massimiliano Russo , Steffen Ventz , Lorenzo Trippa

Reinforcement learning (RL) has been widely applied to game-playing and surpassed the best human-level performance in many domains, yet there are few use-cases in industrial or commercial settings. We introduce OR-Gym, an open-source…

Many settings involve sequential decision-making where a set of actions can be chosen at each time step, each action provides a stochastic reward, and the distribution for the reward of each action is initially unknown. However, frequent…

最优化与控制 · 数学 2019-10-21 Yonatan Mintz , Anil Aswani , Philip Kaminsky , Elena Flowers , Yoshimi Fukuoka

We propose a new computational-level objective function for theoretical biology and theoretical neuroscience that combines: reinforcement learning, the study of learning with feedback via rewards; rate-distortion theory, a branch of…

神经元与认知 · 定量生物学 2025-03-21 Sarah Marzen

Ordinary differential equation (ODE) is widely used in modeling biological and physical processes in science. In this article, we propose a new reproducing kernel-based approach for estimation and inference of ODE given noisy observations.…

统计方法学 · 统计学 2021-10-26 Xiaowu Dai , Lexin Li

Functional data analysis is a fast evolving branch of statistics. Estimation procedures for the popular functional linear model either suffer from lack of robustness or are computationally burdensome. To address these shortcomings, a…

统计方法学 · 统计学 2021-08-27 Ioannis Kalogridis , Stefan Van Aelst

We study offline constrained reinforcement learning from human feedback with multiple preference oracles. Motivated by applications that trade off performance with safety or fairness, we aim to maximize target population utility subject to…

机器学习 · 计算机科学 2026-04-02 Brenden Latham , Mehrdad Moharrami

In the causal adjustment setting, variable selection techniques based on one of either the outcome or treatment allocation model can result in the omission of confounders, which leads to bias, or the inclusion of spurious variables, which…

统计方法学 · 统计学 2015-11-30 Ashkan Ertefaie , Masoud Asgharian , David Stephens

The aim of this paper is to model an ordinal response variable in terms of vector-valued functional data included on a vector-valued RKHS. In particular, we focus on the vector-valued RKHS obtained when a geometrical object (body) is…

User performance is crucial in interactive systems, capturing how effectively users engage with task execution. Prospectively predicting performance enables the timely identification of users struggling with task demands. While ocular and…

机器学习 · 计算机科学 2026-03-20 Yufei Cao , Penny Sweetser , Ziyu Chen , Xuanying Zhu

A reduced-rank mixed effects model is developed for robust modeling of sparsely observed paired functional data. In this model, the curves for each functional variable are summarized using a few functional principal components, and the…

统计方法学 · 统计学 2023-08-08 Huiya Zhou , Xiaomeng Yan , Lan Zhou

The contextual bandit framework is widely used to solve sequential optimization problems where the reward of each decision depends on auxiliary context variables. In settings such as medicine, business, and engineering, the decision maker…

机器学习 · 统计学 2025-03-17 Kevin Li , Eric Laber

Artificial behavioral agents are often evaluated based on their consistent behaviors and performance to take sequential actions in an environment to maximize some notion of cumulative reward. However, human decision making in real life…

人工智能 · 计算机科学 2021-12-28 Baihan Lin , Guillermo Cecchi , Djallel Bouneffouf , Jenna Reinen , Irina Rish

Discrete but ordered covariates are quite common in applied statistics, and some regularized fitting procedures have been proposed for proper handling of ordinal predictors in statistical modeling. In this study, we show how quadratic…

统计方法学 · 统计学 2022-04-25 Jan Gertheiss , Fabian Scheipl , Tina Lauer , Harald Ehrhardt

We consider reinforcement learning in an environment modeled by an episodic, finite, stage-dependent Markov decision process of horizon $H$ with $S$ states, and $A$ actions. The performance of an agent is measured by the regret after…

Surveys that rely on ordinal polychotomous (Likert-like) items are widely employed to capture individual preferences because they allow respondents to express both the direction and strength of their preferences. Latent factor models…

统计方法学 · 统计学 2026-01-28 Rayleigh Lei , Abel Rodriguez

We study episodic reinforcement learning (RL) in non-stationary linear kernel Markov decision processes (MDPs). In this setting, both the reward function and the transition kernel are linear with respect to the given feature maps and are…

机器学习 · 计算机科学 2024-12-24 Han Zhong , Zhongren Chen , Zhuoran Yang , Zhaoran Wang , Csaba Szepesvári

Most off-policy evaluation methods for contextual bandits have focused on the expected outcome of a policy, which is estimated via methods that at best provide only asymptotic guarantees. However, in many applications, the expectation may…

机器学习 · 统计学 2022-10-27 Muhammad Faaiz Taufiq , Jean-Francois Ton , Rob Cornish , Yee Whye Teh , Arnaud Doucet

Learning neural set functions becomes increasingly more important in many applications like product recommendation and compound selection in AI-aided drug discovery. The majority of existing works study methodologies of set function…

机器学习 · 计算机科学 2023-05-24 Zijing Ou , Tingyang Xu , Qinliang Su , Yingzhen Li , Peilin Zhao , Yatao Bian

This paper introduces consensus-based primal-dual methods for distributed online optimization where the time-varying system objective function $f_t(\mathbf{x})$ is given as the sum of local agents' objective functions, i.e.,…

最优化与控制 · 数学 2017-06-01 Soomin Lee , Michael M. Zavlanos