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Self-regulation of living tissue as an example of self-organization phenomena in active fractal systems of biological, ecological, and social nature is under consideration. The characteristic feature of these systems is the absence of any…

组织与器官 · 定量生物学 2008-12-02 Wassily Lubashevsky , Ihor Lubashevsky , Reinhard Mahnke

The intracellular transport process plays an important role in delivering essential materials throughout branched geometries of neurons for their survival and function. Many neurodegenerative diseases have been associated with the…

生物物理 · 物理学 2021-08-31 Angran Li , Yongjie Jessica Zhang

A variety of complex mechanisms, from chemical reaction pathways to active fluctuations, orchestrate molecular transport in intracellular environments. Despite significant recent progress in visualizing and probing these processes, little…

统计力学 · 物理学 2024-07-29 Ardra Suchitran , Sreekanth K Manikandan

We consider a Stokes flow coupled with advective-diffusive transport in an evolving domain with boundary conditions allowing for inflow and outflow. The evolution of the domain is induced by the transport process, leading to a fully coupled…

偏微分方程分析 · 数学 2026-02-10 Kilian Hacker , Maria Neuss-Radu

Transport networks are crucial for the functioning of natural and technological systems. We study a mathematical model of vascular network adaptation, where the network structure dynamically adjusts to changes in blood flow and pressure.…

适应与自组织系统 · 物理学 2023-06-01 Konstantin Klemm , Erik Andreas Martens

By assuming that tau protein can be in seven kinetic states, we developed a model of tau protein transport in the axon and in the axon initial segment (AIS). Two separate sets of kinetic constants were determined, one in the axon and the…

亚细胞过程 · 定量生物学 2020-10-02 Ivan A. Kuznetsov , Andrey V. Kuznetsov

The vascular network of leaves, comprising xylem and phloem, is a highly optimized system for the delivery of water, nutrients, and sugars. The design rules for these naturally occurring networks have been studied since the time of Leonardo…

生物物理 · 物理学 2024-11-01 Lars Erik J. Skjegstad , Julius B. Kirkegaard

Transport networks are crucial to the functioning of natural and technological systems. Nature features transport networks that are adaptive over a vast range of parameters, thus providing an impressive level of robustness in supply.…

适应与自组织系统 · 物理学 2017-11-28 Erik Andreas Martens , Konstantin Klemm

Many foraging microorganisms rely upon cellular transport networks to deliver nutrients, fluid and organelles between different parts of the organism. Networked organisms ranging from filamentous fungi to slime molds demonstrate a…

适应与自组织系统 · 物理学 2020-12-08 Cassidy Mentus , Marcus Roper

Inspired by experiments on the actin driven propulsion of micrometer sized beads we develop and study a minimal mechanical model of a two-dimensional network of stiff elastic filaments grown from the surface of a cylinder. Starting out from…

软凝聚态物质 · 物理学 2010-11-16 Denis Caillerie , Karin John , Chaouqi Misbah , Philippe Peyla , Annie Raoult

Cell polarization relies on long-range cortical flows, which are driven by active stresses and resisted by the cytoskeletal network. While the general mechanisms that contribute to cortical flows are known, a quantitative understanding of…

Biological transport networks adapt through dynamic interactions between material transport and structural modification during growth and development. In this work, we present a model of transport network growth driven by local material…

生物物理 · 物理学 2025-03-27 Chanoknun Sintavanuruk , Yoichiro Mori , Reza Farhadifar , Eleni Katifori

Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on…

生物物理 · 物理学 2022-06-22 Harmen Wierenga , Pieter Rein ten Wolde

We examine the mechanism of bundling of cytoskeletal actin filaments by two representative bundling proteins, fascin and espin. Small-angle X-ray studies show that increased binding from linkers drives a systematic \textit{overtwist} of…

软凝聚态物质 · 物理学 2015-05-14 Homin Shin , Kirstin R. Purdy Drew , James R. Bartles , Gerard C. L. Wong , Gregory M. Grason

Active gels are a class of biologically-relevant material containing embedded agents that spontaneously generate forces acting on a sparse filament network. In vitro experiments of protein filaments and molecular motors have revealed a…

软凝聚态物质 · 物理学 2024-06-03 David A. Head , Gerhard Gompper , W. J. Briels

Myosin II molecular motors slide actin filaments relatively to each other and are essential for force generation, motility and mechanosensing in animal cells. For non-muscle cells, evolution has resulted in three different isoforms, which…

细胞行为 · 定量生物学 2025-08-28 Nils O. Winkler , Oliver M. Drozdowski , Falko Ziebert , Ulrich S. Schwarz

Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large. The cytoskeleton,…

生物物理 · 物理学 2017-09-20 Cecile Appert-Rolland , Maximilian Ebbinghaus , Ludger Santen

Within cells, vesicles and proteins are actively transported several micrometers along the cytoskeletal filaments. The transport along microtubules is propelled by dynein and kinesin motors, which carry the cargo in opposite directions.…

生物物理 · 物理学 2020-05-20 Robin Jose , Ludger Santen

We give a description of cell diffusion in a soft tissue, paying special attention to the coupling of force, matter, and microforce balance laws through a suitable dissipation principle. To this end, we cast our framework into a multi-level…

软凝聚态物质 · 物理学 2024-12-19 Amabile Tatone , Filippo Recrosi , Giuseppe Tomassetti

Following up on a previous work we examine a model of transportation network in some source-sink flow paradigm subjected to growth and resource allocation. The model is inspired from plants, and we add rules and factors that are analogous…

适应与自组织系统 · 物理学 2021-02-03 Olivier Bui , Xavier Leoncini