相关论文: Self-similar shapes under Errera division rule on …
Cross-sections of cell shapes in a tissue monolayer typically resemble a tiling of convex polygons. Yet, examples exist where the polygons are not convex with curved cell-cell interfaces, as seen in the adaxial epidermis. To date,…
During the development of an organism, cells must coordinate and organize to generate the correct shape, structure, and spatial patterns of tissues and organs, a process known as morphogenesis. The morphogenesis of embryonic tissues is…
This article examines the shape of a surface obtained by a hanging flexible, inelastic material with prescribed area and boundary curve. The shape of this surface, after being turned upside down, is a model for cupolas (or domes) under the…
In this paper, a different perspective of constructing the CA models is proposed. Its kernel, the Local Symmetric Distribution Principle, relates to some fundamental concepts in physics, which maybe raise a wide interest. With a rich…
An elastic bilayer, consisting of an equibiaxially pre-stretched sheet bonded to a stress-free one, spontaneously morphs into curved shapes in the absence of external loads or constraints. Using experiments and numerical simulations, we…
The integrated mean curvature of a simplicial manifold is well understood in both Regge Calculus and Discrete Differential Geometry. However, a well motivated pointwise definition of curvature requires a careful choice of volume over which…
In this paper we consider a random partition of the plane into cells, the partition being based on the nodes and links of a {\it random planar geometric graph}. The resulting structure generalises the \emph{random \tes}\ hitherto studied in…
The Vertex Model for epithelia models the apical surface of the tissue by a tiling, with polygons representing cells and edges representing cell-cell junctions. The mechanics are described by an energy governed by deviations from a target…
Real cortical tissue curves and folds according to experimental data. However, our current simulations only use unfolded cortical layers. This project extends the cortical slice model in order to be able to specify arbitrary curvatures to…
How the cells break symmetry and organize their edge activity to move directionally is a fun- damental question in cell biology. Physical models of cell motility commonly rely on gradients of regulatory factors and/or feedback from the…
Biological cells in soft materials can be modeled as anisotropic force contraction dipoles. The corresponding elastic interaction potentials are long-ranged ($\sim 1/r^3$ with distance $r$) and depend sensitively on elastic constants,…
The phenomenological model for cell shape deformation and cell migration (Chen et.al. 2018; Vermolen and Gefen 2012) is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell…
In this paper a model of subscriber telephone network based on the concept of cellular automata is elaborated. Some fractal properties inherent in the model are revealed that vary depending on parameters assigning its operation rules. The…
We investigate the use of an extension of rule-based modelling for cellular signalling to create a structured space of model variants. This enables the incremental development of rule sets that start from simple mechanisms and which, by a…
We investigate how thin structures change their shape in response to non-mechanical stimuli that can be interpreted as variations in the structure's natural curvature. Starting from the theory of non-Euclidean plates and shells, we derive…
The paper introduces a PDE model for the growth of a tree stem or a vine. The equations describe the elongation due to cell growth, and the response to gravity and to external obstacles. An additional term accounts for the tendency of a…
The organization of cells within tissues plays a vital role in various biological processes, including development and morphogenesis. As a result, understanding how cells self-organize in tissues has been an active area of research. In our…
Compliant environments can mediate interactions between mechanically active cells like fibroblasts. Starting with a phenomenological model for the behaviour of single cells, we use extensive Monte Carlo simulations to predict non-trivial…
The shape of a liquid surface bounded by an acute or obtuse planar angular sector is considered by using classical analysis methods. For acute angular sectors the two principal curvatures are of the order of the (fixed) mean curvature. But…
We formulate a theory of shape valid for objects of arbitrary dimension whose contours are path connected. We apply this theory to the design and modeling of viable trajectories of complex dynamical systems. Infinite families of…