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While the Artificial Pancreas is effective in regulating the blood glucose in the safe range of 70-180 mg/dl in type 1 diabetic patients, the high intra-patient variability, as well as exogenous meal disturbances, poses a serious challenge.…

系统与控制 · 电气工程与系统科学 2022-06-30 Bhabani Shankar Dey , Anirudh Nath , Abhilash Patel , Indra Narayan Kar

In this paper, we present a model free approach to calculate long-acting insulin doses for Type 2 Diabetic (T2D) subjects in order to bring their blood glucose (BG) concentration to be within a safe range. The proposed strategy tunes the…

系统与控制 · 电气工程与系统科学 2022-12-29 Mohamad Al Ahdab , Torben Knudsen , Jakob Stoustrup , John Leth

Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…

定量方法 · 定量生物学 2025-02-04 Soon Jynn Chu , Nalaka Amarasiri , Sandesh Giri , Priyata Kafle

Sustained high levels of blood glucose in type 2 diabetes (T2DM) can have disastrous long-term health consequences. An essential component of clinical interventions for T2DM is monitoring dietary intake to keep plasma glucose levels within…

We present the design and \textit{in-silico} evaluation of a closed-loop insulin delivery algorithm to treat type 1 diabetes (T1D) consisting in a data-driven multi-step-ahead blood glucose (BG) predictor integrated into a Linear…

系统与控制 · 电气工程与系统科学 2023-07-25 Eleonora Maria Aiello , Mehrad Jaloli , Marzia Cescon

Precise glucose level monitoring is critical for people with diabetes to avoid serious complications. While there are several methods for continuous glucose level monitoring, research on maintenance devices is limited. To mitigate the gap,…

机器学习 · 计算机科学 2024-06-10 Azmine Toushik Wasi

Diabetes is a serious chronic metabolic disease. In the recent years, more and more consumer technology enterprises focusing on human health are committed to implementing accurate and non-invasive blood glucose algorithm in their products.…

机器学习 · 计算机科学 2025-03-05 Yiting Wei , Bingo Wing-Kuen Ling , Qing Liu , Jiaxin Liu

The human insulin-glucose metabolism is a time-varying process, which is partly caused by the changing insulin sensitivity of the body. This insulin sensitivity follows a circadian rhythm and its effects should be anticipated by any…

系统与控制 · 电气工程与系统科学 2021-01-29 Lukas Ortmann , Dawei Shi , Eyal Dassau , Francis J. Doyle , Berno J. E. Misgeld , Steffen Leonhardt

Regular physical activity is known to be beneficial to people suffering from diabetes type 2. Nevertheless, most such people are sedentary. Smartphones create new possibilities for helping people to adhere to their physical activity goals,…

计算机与社会 · 计算机科学 2018-05-16 Irit Hochberg , Guy Feraru , Mark Kozdoba , Shie Mannor , Moshe Tennenholtz , Elad Yom-Tov

Patients with Type I Diabetes (T1D) must take insulin injections to prevent the serious long term effects of hyperglycemia - high blood glucose (BG). Patients must also be careful not to inject too much insulin because this could induce…

机器学习 · 计算机科学 2019-04-01 Neil C. Borle , Edmond A. Ryan , Russell Greiner

Diabetes is one of the deadliest diseases in the world and affects nearly 10 percent of the global adult population. Fortunately, powerful new technologies allow for a consistent and reliable treatment plan for people with diabetes. One…

其他定量生物学 · 定量生物学 2021-01-08 Julia Ann Jose , Trae Waggoner , Sudarsan Manikandan

In type 2 diabetes (T2D) treatment, finding a safe and effective basal insulin dose is a challenge. The dose-response is highly individual and to ensure safety, people with T2D titrate by slowly increasing the daily insulin dose to meet…

系统与控制 · 电气工程与系统科学 2022-11-28 Sarah Ellinor Engell , Tinna Björk Aradóttir , Tobias K. S. Ritschel , Henrik Bengtsson , John Bagterp Jørgensen

In the U.S., over a third of adults are pre-diabetic, with 80\% unaware of their status. This underlines the need for better glucose monitoring to prevent type 2 diabetes and related heart diseases. Existing wearable glucose monitors are…

信号处理 · 电气工程与系统科学 2024-06-26 Yidong Zhu , Nadia B Aimandi , Mohammad Arif Ul Alam

The problem of real time prediction of blood glucose (BG) levels based on the readings from a continuous glucose monitoring (CGM) device is a problem of great importance in diabetes care, and therefore, has attracted a lot of research in…

机器学习 · 计算机科学 2021-06-30 H. N. Mhaskar , S. V. Pereverzyev , M. D. van der Walt

Blood glucose (BG) management is crucial for type-1 diabetes patients resulting in the necessity of reliable artificial pancreas or insulin infusion systems. In recent years, deep learning techniques have been utilized for a more accurate…

机器学习 · 计算机科学 2021-01-19 Md Fazle Rabby , Yazhou Tu , Md Imran Hossen , Insup Le , Anthony S Maida , Xiali Hei

Objective: The design of an Artificial Pancreas (AP) to regulate blood glucose levels requires reliable control methods. Model Predictive Control has emerged as a promising approach for glycemia control. However, model--based control…

最优化与控制 · 数学 2022-02-02 Claudia Lopez-Zazueta , Øyvind Stavdahl , Anders Lyngvi Fougner

In this paper, a novel robust tracking control scheme for a general class of discrete-time nonlinear systems affected by unknown bounded uncertainty is presented. By solving a parameterized optimal tracking control problem subject to the…

系统与控制 · 电气工程与系统科学 2023-12-08 Alexandros Tanzanakis , John Lygeros

Postprandial glucose collected through continuous glucose monitoring (CGM) provides critical information for assessing metabolic capacity and guiding dietary recommendations. Traditional approaches summarize these data into scalar measures,…

定量方法 · 定量生物学 2026-04-03 Marcos Matabuena , Joe Sartini , Francisco Gude

Artificial intelligence (AI) algorithms are a critical part of state-of-the-art digital health technology for diabetes management. Yet, access to large high-quality datasets is creating barriers that impede development of robust AI…

人工智能 · 计算机科学 2025-07-21 Temiloluwa Prioleau , Baiying Lu , Yanjun Cui

Research in diabetes, especially when it comes to building data-driven models to forecast future glucose values, is hindered by the sensitive nature of the data. Because researchers do not share the same data between studies, progress is…

定量方法 · 定量生物学 2020-09-10 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi