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Left ventricular assist devices (LVADs) can provide mechanical support for a failing heart as bridge to transplant and destination therapy. Physiological control systems for LVADs should be designed to respond to changes in hemodynamic…

系统与控制 · 电气工程与系统科学 2020-02-14 Masoud Fetanat , Michael Stevens , Christopher Hayward , Nigel Hamilton Lovell

Left ventricular assist devices (LVADs) are surgically implanted mechanical pumps that improve survival rates for individuals with advanced heart failure. While life-saving, LVAD therapy is also associated with high morbidity, which can be…

信号处理 · 电气工程与系统科学 2020-02-28 Xinlin J. Chen , Emma T. LaPorte , Leslie M. Collins , Priyesh Patel , Ravi Karra , Boyla O. Mainsah

Left ventricular assist devices (LVADs) are mechanical pumps, which can be used to support heart failure (HF) patients as bridge to transplant and destination therapy. To automatically adjust the LVAD speed, a physiological control system…

系统与控制 · 电气工程与系统科学 2021-05-04 Masoud Fetanat , Michael Stevens , Christopher Hayward , Nigel H. Lovell

Medical therapy for patients with severe heart disease often relies on left ventricular assist devices (LVADs). It is an ongoing topic of research how complications like stagnation and thrombosis can be prevented by using artificial…

流体动力学 · 物理学 2025-03-31 Maximilian R. Schuster , Nico Dirkes , Fabian Key , Stefanie Elgeti , Marek Behr

Left ventricular assist devices (LVADs) are used to provide haemodynamic support to patients with critical cardiac failure. Severe complications can occur because of the modifications of the blood flow in the aortic region. In this work,…

The heart is the central part of the cardiovascular network. Its role is to pump blood to various body organs. Many cardiovascular diseases occur due to an abnormal functioning of the heart. A diseased heart leads to severe complications…

医学物理 · 物理学 2024-11-19 Mahesh S. Nagargoje , Eneko Lazpita , Jesús Garicano-Mena , Soledad Le Clainche

Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by…

组织与器官 · 定量生物学 2019-04-19 Masoud Farahmand , Minoo N. Kavarana , Ethan O. Kung

Percutaneous catheter pumps are intraventricular temporary mechanical circulatory support (MCS) devices that are positioned across the aortic valve into the left ventricle (LV) and provide continuous antegrade blood flow from the LV into…

医学物理 · 物理学 2023-12-11 Greg W. Burgreen , Mansur Zhussupbekov , Rodrigo Méndez Rojano , James F. Antaki

The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly…

流体动力学 · 物理学 2021-03-30 Francesco Viola , Valentina Meschini , Roberto Verzicco

Valvular heart diseases are growing concern in impoverished parts of the world, such as Southern-Africa, claiming more than 31 % of total deaths related to cardiovascular diseases. The ability to model the effects of regurgitant and…

医学物理 · 物理学 2022-04-11 Ryno Laubscher , Jacques Liebenberg , Philip Herbst

Left ventricular diastolic dysfunction (LVDD) is a group of diseases that adversely affect the passive phase of the cardiac cycle and can lead to heart failure. While left ventricular end-diastolic pressure (LVEDP) is a valuable prognostic…

组织与器官 · 定量生物学 2025-01-23 Emilio A. Mendiola , Raza Rana Mehdi , Dipan J. Shah , Reza Avazmohammadi

Left ventricular (LV) function is an important factor in terms of patient management, outcome, and long-term survival of patients with heart disease. The most recently published clinical guidelines for heart failure recognise that over…

Left ventricular assist devices (LVADs) are an increasingly common therapy for patients with advanced heart failure. However, implantation of the LVAD increases the risk of stroke, infection, bleeding, and other serious adverse events…

The present focus of heart flow studies is largely based on flow within the left ventricle and how this flow changes when subject to disease. However, despite recent advancements, a simple tractable model of even healthy left ventricular…

流体动力学 · 物理学 2019-03-18 Giuseppe Di Labbio , Lyes Kadem

More than 23 million people are suffered by Heart failure worldwide. Despite the modern transplant operation is well established, the lack of heart donations becomes a big restriction on transplantation frequency. With respect to this…

流体动力学 · 物理学 2017-06-29 Chen Song , Vincent Heuveline

This paper presents a delay-dependent parameter-varying control design approach to address the automated blood pressure regulation problem in the critical patient resuscitation using closed-loop administration of vasopressors. The mean…

系统与控制 · 电气工程与系统科学 2019-10-03 Shahin Tasoujian , Karolos Grigoriadis , Matthew Franchek

Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. The contraction and relaxation of left ventricle (LV) is the main driving force of blood circulation. Altered LV hemodynamics is believed to be associated with…

医学物理 · 物理学 2019-11-04 Fanwei Kong , Christoph Augustin , Kevin Sack , Shawn Shadden

- Modeling Human cardiovascular system is always an important issue. One of the most effective methods is using lumped model to reach to a complete model of human cardiovascular system. Such modeling with advanced considerations is used in…

Accurate estimates of left ventricle elastances based on non-invasive measurements are required for clinical decision-making during treatment of valvular diseases. The present study proposes a parameter discovery approach based on a lumped…

医学物理 · 物理学 2022-05-26 Ryno Laubscher , Johan Van Der Merwe , Jacques Liebenberg , Philip Herbst

A minimal model for mechanical motion of the left ventricle is proposed. The model assumes the left ventricle to be a harmonic oscillator with two distinct phases, simulating the systolic and diastolic phases, at which both the amplitude…

医学物理 · 物理学 2007-05-23 S. Dubi , C. Dubi , Y. Dubi
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