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Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite…

In this work, we propose a dynamical systems perspective on the modeling of sepsis and its organ-damaging consequences. We develop a functional two-layer network model for sepsis based upon the interaction of parenchymal cells and immune…

Sepsis is a life-threatening and serious global health issue. This study combines knowledge with available hospital data to investigate the potential causes of Sepsis that can be affected by policy decisions. We investigate the underlying…

Sepsis is a life-threatening organ malfunction caused by the host's inability to fight infection, which can lead to death without proper and immediate treatment. Therefore, early diagnosis and medical treatment of sepsis in critically ill…

Sepsis is an organ dysfunction caused by a deregulated immune response to an infection. Early sepsis prediction and identification allow for timely intervention, leading to improved clinical outcomes. Clinical calculators (e.g., the…

Sepsis is a condition caused by the body's overwhelming and life-threatening response to infection, which can lead to tissue damage, organ failure, and finally death. Common signs and symptoms include fever, increased heart rate, increased…

Atherosclerosis, a chronic lesion of vascular wall, remains a leading cause of death and loss of life years. Classical hypotheses for atherosclerosis are long-standing mainly to explain atherogenesis. Unfortunately, these hypotheses may not…

When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as Sepsis and can culminate in organ failure and…

Sepsis affects millions of people worldwide each year. It occurs when a normal human immune response to a bacterial, viral or fungal infection becomes dysfunctional and triggers widespread inflammation that results in severe tissue damage…

Atherosclerosis is a disease characterized by the development of atherosclerotic plaques (APs) in arterial endothelium. The APs in part of an arterial wall are inhomogeneous on size and on distribution. In order to understand this…

Objective: Sepsis is one of the most serious hospital conditions associated with high mortality. Sepsis is the result of a dysregulated immune response to infection that can lead to multiple organ dysfunction and death. Due to the wide…

Sepsis is a life threatening medical condition that occurs when the body has an extreme response to infection, leading to widespread inflammation, organ failure, and potentially death. Because sepsis can worsen rapidly, early detection is…

Atherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL…

Sepsis is the leading cause of in-hospital mortality in the USA. Early sepsis onset prediction and diagnosis could significantly improve the survival of sepsis patients. Existing predictive models are usually trained on high-quality data…

Sepsis is a life-threatening condition with organ dysfunction and is a leading cause of death and critical illness worldwide. Even a few hours of delay in the treatment of sepsis results in increased mortality. Early detection of sepsis…

Age-related muscle decline, a condition referred to as sarcopenia and defined as loss in muscle mass and muscle strength over time, is one of the most pervasive problems of the elderly, such that significant declines in strength and…

Focal cortical dysplasias (FCDs) are the most common cause of treatment resistant epilepsy affecting the pediatric population. Most individuals with FCD have seizure onset during the first five years of life and the majority will have…

Epilepsy is a neurological disorder characterized by seizures and epileptic events intertwined with religious and personal beliefs since prehistoric times. This review paper explores the historical context and challenges in defining…

Sepsis, characterized by a dysregulated immune response to infection, results in significant mortality, morbidity, and healthcare costs. The timely prediction of sepsis progression is crucial for reducing adverse outcomes through early…

Multiple Sclerosis (MS) is a disorder that usually appears in adults in their thirties. It has a prevalence that ranges between 2 and 150 per 100 000. Epidemiological studies of MS have provided hints on possible causes for the disease…