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Neuronal cells present periodic trains of localized voltage spikes involving a large amount of different ionic channels. A relevant question is whether this is a cooperative effect or it could also be an intrinsic property of individual…

生物物理 · 物理学 2018-04-17 Laureano Ramírez-Piscina , José M. Sancho

Routing mechanisms for stochastic networks are often designed to produce state space collapse (SSC) in a heavy-traffic limit, i.e., to confine the limiting process to a lower-dimensional subset of its full state space. In a fluid limit, a…

概率论 · 数学 2014-07-29 Ohad Perry , Ward Whitt

Fluctuation analysis is a method which allows measurement of the single channel current of ion channels even when it is too small to be resolved directly with the patch clamp technique. This is the case for voltage-gated Ca2+ channels…

神经元与认知 · 定量生物学 2017-12-13 Christian Scheppach , Hugh P. C. Robinson

In this paper, we propose and validate a two-species Multiscale model for a Poisson-Nernst-Planck (PNP) system, focusing on the correlated motion of positive and negative ions under the influence of a trap. Specifically, we aim to model…

数值分析 · 数学 2026-04-28 Clarissa Astuto , Giovanni Russo

Particles in pressure-driven channel flow are often inhomogeneously distributed. Two modes of low-Reynolds number instability, absent in Poiseuille flow of clean fluid, are created by inhomogeneous particle loading, and their mechanism is…

流体动力学 · 物理学 2024-11-27 Anup Kumar , Rama Govindarajan

We present a two channel driven lattice gas model with oppositely directed species moving on two parallel lanes with lane switching processes. We study correlated lane switching mechanism for particles so that switching may occur with…

统计力学 · 物理学 2015-05-28 Sudipto Muhuri , Ignacio Pagonabarraga

The single-particle density of states and the tunneling conductance are studied for a two-dimensional BCS-like Hamiltonian with a d_{x^2-y^2}-gap and phase fluctuations. The latter are treated by a classical Monte Carlo simulation of an XY…

超导电性 · 物理学 2009-11-07 T. Eckl , D. J. Scalapino , E. Arrigoni , W. Hanke

Ion traps are a versatile tool to study nonequilibrium statistical physics, due to the tunability of dissipation and nonlinearity. We propose an experiment with a chain of trapped ions, where dissipation is provided by laser heating and…

斑图形成与孤子 · 物理学 2011-04-06 Tony E. Lee , M. C. Cross

Numerical methods are proposed for an advanced Poisson-Nernst-Planck-Fermi (PNPF) model for studying ion transport through biological ion channels. PNPF contains many more correlations than most models and simulations of channels, because…

生物大分子 · 定量生物学 2015-06-22 Jinn-Liang Liu , Bob Eisenberg

The dynamics and the steady states of a point-like tracer particle immersed in a confined critical fluid are studied. The fluid is modeled field-theoretically in terms of an order parameter (concentration or density field) obeying…

统计力学 · 物理学 2023-01-03 Markus Gross

A continuously measured quantum system with multiple jump channels gives rise to a stochastic process described by random jump times and random emitted symbols, representing each jump channel. While much is known about the waiting time…

量子物理 · 物理学 2023-06-21 Gabriel T. Landi

Canalization is a classic concept in Developmental Biology that is thought to be an important feature of evolving systems. In a Boolean network it is a form of network robustness in which a subset of the input signals control the behavior…

分子网络 · 定量生物学 2015-05-28 Matthew D. Reichl , Kevin E. Bassler

We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabilities for the opening/closing of channels which release…

patt-sol · 物理学 2009-10-31 Markus Baer , Martin Falcke , Herbert Levine , Lev S. Tsimring

It is shown that bifurcations of the mean-field dynamics of a Bose-Einstein condensate can be related with the quantum phase transitions of the original many-body system. As an example we explore the intra-band tunneling in the…

其他凝聚态物理 · 物理学 2009-11-13 V. S. Shchesnovich , V. V. Konotop

Gene expression has a stochastic component owing to the single molecule nature of the gene and the small number of copies of individual DNA binding proteins in the cell. We show how the statistics of such systems can be mapped on to quantum…

无序系统与神经网络 · 物理学 2009-11-10 Masaki Sasai , Peter G. Wolynes

Measured responses from visual cortical neurons show that spike times tend to be correlated rather than exactly Poisson distributed. Fano factors vary and are usually greater than 1 due to the tendency of spikes being clustered into bursts.…

神经元与认知 · 定量生物学 2007-05-23 Alexander Lerchner , Mandana Ahmadi , John Hertz

Gating mechanisms are widely used in neural network models, where they allow gradients to backpropagate more easily through depth or time. However, their saturation property introduces problems of its own. For example, in recurrent models…

神经与进化计算 · 计算机科学 2020-06-22 Albert Gu , Caglar Gulcehre , Tom Le Paine , Matt Hoffman , Razvan Pascanu

Key features of biological activity can often be captured by transitions between a finite number of semi-stable states that correspond to behaviors or decisions. We present here a broad class of dynamical systems that are ideal for modeling…

动力系统 · 数学 2022-12-14 Megan Morrison , Lai-Sang Young

We consider the overdamped dynamics of a paradigmatic long-range system of particles residing on the sites of a one-dimensional lattice, in the presence of thermal noise. The internal degree of freedom of each particle is a periodic…

统计力学 · 物理学 2013-12-03 Shamik Gupta , Alessandro Campa , Stefano Ruffo

We report and characterize the emergence of a noise-induced state of quenched disorder in a generic model describing a dense sheet of active polar disks with non-isotropic rotational and translational dynamics. In this state, randomly…

软凝聚态物质 · 物理学 2023-04-10 Guozheng Lin , Zhangang Han , Amir Shee , Cristián Huepe