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DNA translocation through nanopores is one of the most promising strategies for the next-generation sequencing technologies. Most part of experimental and numerical works has focused on polymer translocation biased by electrophoresis, where…

软凝聚态物质 · 物理学 2018-02-07 Timothée Menais

We investigate the dynamics of polymer translocation through a nanopore using two-dimensional Langevin dynamics simulations. In the absence of external driving force, we consider a polymer which is initially placed in the middle of the pore…

软凝聚态物质 · 物理学 2007-05-23 Ilkka Huopaniemi , Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying

The translocation of a polymer through a pore in a membrane separating fluids of different viscosities is studied via several computational approaches. Starting with the polymer halfway, we find that as a viscosity difference across the…

软凝聚态物质 · 物理学 2013-04-17 Hendrick W. de Haan , Gary W. Slater

Polymer translocation has long been a topic of interest in the field of biological physics given its relevance in both biological (protein and DNA/RNA translocation through nuclear and cell membranes) and technological processes (nanopore…

软凝聚态物质 · 物理学 2023-09-11 Alejandro Sainz-Agost , Fernando Falo , Alessandro Fiasconaro

In this work we study the noise induced effects on the dynamics of short polymers crossing a potential barrier, in the presence of a metastable state. An improved version of the Rouse model for a flexible polymer has been adopted to mimic…

统计力学 · 物理学 2009-11-13 N. Pizzolato , A. Fiasconaro , B. Spagnolo

We study translocation of semiflexible polymers driven by force $f_d$ inside a nanometer-scale pore using our three-dimensional Langevin dynamics model. We show that the translocation time $\tau$ increases with increasing bending rigidity…

生物物理 · 物理学 2018-06-27 Pauli M. Suhonen , Riku P. Linna

We employ a three-dimensional molecular dynamics to simulate translocation of a polymer through a nanopore driven by an external force. The translocation is investigated for different three pore diameter and two different external forces.…

计算物理 · 物理学 2019-12-03 Mohammadreza Niknam Hamidabad , Rouhollah Haji Abdolvahab

We employ 3D Langevin Dynamics simulations to study the dynamics of polymer chains translocating through a nanopore in presence of asymmetric solvent conditions. Initially a large fraction ($>$ 50%) of the chain is placed at the…

软凝聚态物质 · 物理学 2010-06-09 Christopher Lorscher , Tapio Ala-Nissila , Aniket Bhattacharya

Using Langevin dynamics simulations in three dimensions (3D), we investigate the dynamics of polymer translocation into the regions between two parallel plane walls with separation $R$ under a driving force $F$, respectively. Compared with…

软凝聚态物质 · 物理学 2010-08-18 Kaifu Luo , Ralf Metzler

We investigate the translocation of stiff polymers in the presence of binding particles through a nanopore by two-dimensional Langevin dynamics simulations. We find that the mean translocation time shows a minimum as a function of the…

软凝聚态物质 · 物理学 2015-06-12 Wancheng Yu , Yiding Ma , Kaifu Luo

Polymer translocation is a promising strategy for the next-generation DNA sequencing technologies. The use of biological and synthetic nano-pores, however, still suffers from serious drawbacks. In particular, the width of the membrane layer…

软凝聚态物质 · 物理学 2017-11-30 Timothee Menais , Stefano Mossa , Arnaud Buhot

We consider the passage of long polymers of length N through a hole in a membrane. If the process is slow, it is in principle possible to focus on the dynamics of the number of monomers s on one side of the membrane, assuming that the two…

软凝聚态物质 · 物理学 2009-11-10 Yacov Kantor , Mehran Kardar

We consider the dynamics of a translocation process of a flexible linear polymer through a nanopore into an environment of active rods in the {\it trans} side. Using Langevin dynamics simulations we find that the rods facilitate…

软凝聚态物质 · 物理学 2022-11-15 Hamidreza Khalilian , Jalal Sarabadani , Tapio Ala-Nissila

We study the driven translocation of a flexible polymer through an interacting conical pore using Langevin dynamics simulations. We find that, for a fixed value of externally applied force and pore polymer interaction strength, the mean…

软凝聚态物质 · 物理学 2021-02-17 Rajneesh Kumar , Abhishek Chaudhuri , Rajeev Kapri

We investigate polymer translocation through a nanopore under a pulling force using Langevin dynamics simulations. We concentrate on the influence of the chain length $N$ and the pulling force $F$ on the translocation time $\tau$. The…

软凝聚态物质 · 物理学 2007-06-27 Ilkka Huopaniemi , Kaifu luo , Tapio Ala-Nissila , See-Chen Ying

Using two dimensional Langevin dynamics simulations, we investigate the dynamics of polymer translocation into a fluidic channel with diameter $R$ through a nanopore under a driving force $F$. Due to the crowding effect induced by the…

软凝聚态物质 · 物理学 2010-08-30 Kaifu Luo , Ralf Metzler

Motivated by identifying the origin of the bias dependence of tension propagation we investigate methods for measuring tension propagation quantitatively in computer simulations of driven polymer translocation. Here the motion of flexible…

生物物理 · 物理学 2017-12-18 P. M. Suhonen , J. Piili , R. P. Linna

The relaxation dynamics of a polymer wound around a fixed obstacle constitutes a fundamental instance of polymer with twist and torque and it is of relevance also for DNA denaturation dynamics. We investigate it by simulations and Langevin…

软凝聚态物质 · 物理学 2015-06-12 Jean-Charles Walter , Marco Baiesi , Gerard Barkema , Enrico Carlon

We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve translocation probability. At the same time, it also increases…

软凝聚态物质 · 物理学 2007-10-01 Kaifu Luo , Tapio Ala-Nissila , See-chen Ying , Aniket Bhattacharya

We study the translocation of a semiflexible polymer through extended pores with patterned stickiness, using Langevin dynamics simulations. We find that the consequence of pore patterning on the translocation time dynamics is dramatic and…

软凝聚态物质 · 物理学 2018-05-02 Rajneesh Kumar , Abhishek Chaudhuri , Rajeev Kapri
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