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Cellular Electron Cryo-Tomography (CECT) is a powerful imaging technique for the 3D visualization of cellular structure and organization at submolecular resolution. It enables analyzing the native structures of macromolecular complexes and…

定量方法 · 定量生物学 2018-05-16 Chang Liu , Xiangrui Zeng , Ruogu Lin , Xiaodan Liang , Zachary Freyberg , Eric Xing , Min Xu

Cellular processes are governed by macromolecular complexes inside the cell. Study of the native structures of macromolecular complexes has been extremely difficult due to lack of data. With recent breakthroughs in Cellular electron cryo…

定量方法 · 定量生物学 2018-06-12 Chengqian Che , Ruogu Lin , Xiangrui Zeng , Karim Elmaaroufi , John Galeotti , Min Xu

Deep learning model trained by imbalanced data may not work satisfactorily since it could be determined by major classes and thus may ignore the classes with small amount of data. In this paper, we apply deep learning based imbalanced data…

图像与视频处理 · 电气工程与系统科学 2019-08-28 Ziqian Luo , Xiangrui Zeng , Zhipeng Bao , Min Xu

Motivation: Cellular Electron CryoTomography (CECT) enables 3D visualization of cellular organization at near-native state and in sub-molecular resolution, making it a powerful tool for analyzing structures of macromolecular complexes and…

定量方法 · 定量生物学 2017-04-14 Min Xu , Xiaoqi Chai , Hariank Muthakana , Xiaodan Liang , Ge Yang , Tzviya Zeev-Ben-Mordehai , Eric Xing

Cellular Electron Cryo-Tomography (CECT) is a powerful 3D imaging tool for studying the native structure and organization of macromolecules inside single cells. For systematic recognition and recovery of macromolecular structures captured…

计算机视觉与模式识别 · 计算机科学 2018-07-04 Chang Liu , Xiangrui Zeng , Kaiwen Wang , Qiang Guo , Min Xu

Cellular Electron Cryotomography (CryoET) offers the ability to look inside cells and observe macromolecules frozen in action. A primary challenge for this technique is identifying and extracting the molecular components within the crowded…

定量方法 · 定量生物学 2021-08-04 Muyuan Chen , Wei Dai , Ying Sun , Darius Jonasch , Cynthia Y He , Michael F. Schmid , Wah Chiu , Steven J Ludtke

Deploying trained convolutional neural networks (CNNs) to mobile devices is a challenging task because of the simultaneous requirements of the deployed model to be fast, lightweight and accurate. Designing and training a CNN architecture…

Deep neural networks have achieved strong performance in image classification tasks due to their ability to learn complex patterns from high-dimensional data. However, their large computational and memory requirements often limit deployment…

计算机视觉与模式识别 · 计算机科学 2026-03-06 Sai Shi

Cryo-electron tomography (Cryo-ET) is a 3D imaging technique that enables the systemic study of shape, abundance, and distribution of macromolecular structures in single cells in near-atomic resolution. However, the systematic and efficient…

生物大分子 · 定量生物学 2021-06-29 Kai Yi , Jianye Pang , Yungeng Zhang , Xiangrui Zeng , Min Xu

Convolutional neural networks (CNNs) for biomedical image analysis are often of very large size, resulting in high memory requirement and high latency of operations. Searching for an acceptable compressed representation of the base CNN for…

计算机视觉与模式识别 · 计算机科学 2019-09-10 Suraj Mishra , Peixian Liang , Adam Czajka , Danny Z. Chen , X. Sharon Hu

Cryo-electron tomography (cryo-ET) is an imaging technique that allows three-dimensional visualization of macro-molecular assemblies under near-native conditions. Cryo-ET comes with a number of challenges, mainly low signal-to-noise and…

Cellular Electron CryoTomography (CECT) is a 3D imaging technique that captures information about the structure and spatial organization of macromolecular complexes within single cells, in near-native state and at sub-molecular resolution.…

定量方法 · 定量生物学 2018-07-04 Kai Wen Wang , Xiangrui Zeng , Xiaodan Liang , Zhiguang Huo , Eric P. Xing , Min Xu

Compression is a standard procedure for making convolutional neural networks (CNNs) adhere to some specific computing resource constraints. However, searching for a compressed architecture typically involves a series of time-consuming…

图像与视频处理 · 电气工程与系统科学 2021-07-08 Suraj Mishra , Danny Z. Chen , X. Sharon Hu

The deployment of deep convolutional neural networks (CNNs) in many real world applications is largely hindered by their high computational cost. In this paper, we propose a novel learning scheme for CNNs to simultaneously 1) reduce the…

计算机视觉与模式识别 · 计算机科学 2017-08-23 Zhuang Liu , Jianguo Li , Zhiqiang Shen , Gao Huang , Shoumeng Yan , Changshui Zhang

The concept of compressing deep Convolutional Neural Networks (CNNs) is essential to use limited computation, power, and memory resources on embedded devices. However, existing methods achieve this objective at the cost of a drop in…

计算机视觉与模式识别 · 计算机科学 2021-04-20 Waqar Ahmed , Andrea Zunino , Pietro Morerio , Vittorio Murino

Cryogenic electron microscopy (Cryo-EM) has become an essential tool for capturing high-resolution biological structures. Despite its advantage in visualizations, the large storage size of Cryo-EM data file poses significant challenges for…

机器学习 · 计算机科学 2025-12-16 Chunyu Zou

The ability to automatically detect certain types of cells or cellular subunits in microscopy images is of significant interest to a wide range of biomedical research and clinical practices. Cell detection methods have evolved from…

计算机视觉与模式识别 · 计算机科学 2018-02-22 Yao Xue , Nilanjan Ray

Ensemble models comprising of deep Convolutional Neural Networks (CNN) have shown significant improvements in model generalization but at the cost of large computation and memory requirements. In this paper, we present a framework for…

计算机视觉与模式识别 · 计算机科学 2020-04-03 Umar Asif , Jianbin Tang , Stefan Harrer

Background: Single-particle cryo-electron microscopy (cryo-EM) has become a popular tool for structural determination of biological macromolecular complexes. High-resolution cryo-EM reconstruction often requires hundreds of thousands of…

数据分析、统计与概率 · 物理学 2017-09-05 Yanan Zhu , Qi Ouyang , Youdong Mao

Deep convolutional neural networks have shown high efficiency in computer visions and other applications. However, with the increase in the depth of the networks, the computational complexity is growing exponentially. In this paper, we…

机器学习 · 计算机科学 2021-01-08 Ali Mirzaeian , Sai Manoj , Ashkan Vakil , Houman Homayoun , Avesta Sasan
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