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We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy…

机器学习 · 统计学 2018-12-06 Ruidi Chen , Ioannis Paschalidis

The Predictive Approaches to Treatment Effect Heterogeneity statement focused on baseline risk as a robust predictor of treatment effect and provided guidance on risk-based assessment of treatment effect heterogeneity in the RCT setting.…

The quality of healthcare provided by hospitals is subject to considerable variability. Consequently, accurate measurements of hospital performance are essential for various decision-makers, including patients, hospital managers and health…

应用统计 · 统计学 2020-11-16 Eva van Weenen , Stefan Feuerriegel

In the standard difference-in-differences research design, the parallel trends assumption may be violated when the relationship between the exposure trend and the outcome trend is confounded by unmeasured confounders. Progress can be made…

Building models for health prediction based on Electronic Health Records (EHR) has become an active research area. EHR patient journey data consists of patient time-ordered clinical events/visits from patients. Most existing studies focus…

机器学习 · 计算机科学 2022-07-18 Yuxi Liu , Zhenhao Zhang , Antonio Jimeno Yepes , Flora D. Salim

Modelling disease progression of iron deficiency anaemia (IDA) following oral iron supplement prescriptions is a prerequisite for evaluating the cost-effectiveness of oral iron supplements. Electronic health records (EHRs) from the Clinical…

应用统计 · 统计学 2021-07-30 Li Su , Yafeng Cheng , Dora I. A. Pereira , Jonathan J. Powell

This paper examines the identification and estimation of heterogeneous treatment effects in event studies, emphasizing the importance of both lagged dependent variables and treatment effect heterogeneity. We show that omitting lagged…

计量经济学 · 经济学 2025-09-18 Irene Botosaru , Laura Liu

A recent literature has shown that when adoption of a treatment is staggered and average treatment effects vary across groups and over time, difference-in-differences regression does not identify an easily interpretable measure of the…

计量经济学 · 经济学 2022-07-14 John Gardner

Electronic health records (EHR) consist of longitudinal clinical observations portrayed with sparsity, irregularity, and high-dimensionality, which become major obstacles in drawing reliable downstream clinical outcomes. Although there…

机器学习 · 计算机科学 2020-11-17 Ahmad Wisnu Mulyadi , Eunji Jun , Heung-Il Suk

Electronic health records (EHR) often contain varying levels of missing data. This study compared different imputation strategies to identify the most suitable approach for predicting central line-associated bloodstream infection (CLABSI)…

Machine learning provides many powerful and effective techniques for analysing heterogeneous electronic health records (EHR). Administrative Health Records (AHR) are a subset of EHR collected for administrative purposes, and the use of…

机器学习 · 计算机科学 2023-08-29 Adrian Caruana , Madhushi Bandara , Katarzyna Musial , Daniel Catchpoole , Paul J. Kennedy

Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…

计算机与社会 · 计算机科学 2020-11-05 Hua Zheng , Ilya O. Ryzhov , Wei Xie , Judy Zhong

Due to potential applications in chronic disease management and personalized healthcare, the EHRs data analysis has attracted much attention of both researchers and practitioners. There are three main challenges in modeling longitudinal and…

机器学习 · 计算机科学 2019-12-03 Yi Huang , Xiaoshan Yang , Changsheng Xu

Medical studies that depend on electronic health records (EHR) data are often subject to measurement error, as the data are not collected to support research questions under study. These data errors, if not accounted for in study analyses,…

统计方法学 · 统计学 2020-03-10 Eric J. Oh , Bryan E. Shepherd , Thomas Lumley , Pamela A. Shaw

In longitudinal studies using routinely collected data, such as electronic health records (EHRs), patients tend to have more measurements when they are unwell; this informative observation pattern may lead to bias. While semi-parametric…

统计方法学 · 统计学 2024-10-02 Rose Garrett , Brian Feldman , Eleanor Pullenayegum

Intra-physician prescribing variability, the probability that one physician issues discordant decisions for two patients deemed comparable on observed covariates, holds great impact in quality of care, safety and cost. However, there are no…

Linear Discriminant Analysis (LDA) is a well-known technique for feature extraction and dimension reduction. The performance of classical LDA, however, significantly degrades on the High Dimension Low Sample Size (HDLSS) data for the…

机器学习 · 计算机科学 2023-03-09 Sijia Yang , Haoyi Xiong , Kaibo Xu , Licheng Wang , Jiang Bian , Zeyi Sun

This study investigates the impact of quantity and diversity of data on the performance of various machine-learning models for detecting general EEG pathology. We utilized an EEG dataset of 2,993 recordings from Temple University Hospital…

Harmonizing medication data across Electronic Health Record (EHR) systems is a persistent barrier to monitoring medications for opioid use disorder (MOUD). In heterogeneous EHR systems, key prescription attributes are scattered across…

Electronic health records (EHRs) provide an efficient approach to generating rich longitudinal datasets. However, since patients visit as needed, the assessment times are typically irregular and may be related to the patient's health.…

统计方法学 · 统计学 2024-06-07 Rose Garrett , Masum Patel , Brian Feldman , Eleanor Pullenayegum