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Motor-driven cytoskeletal remodeling in cellular systems can often be accompanied by a diffusive-like effect at local scales, but distinguishing the contributions of the ordering process, such as active contraction of a network, from this…

Molecular-motor generated active stresses drive the cytoskeleton away from equilibrium, endowing it with tunable mechanical properties that are essential for diverse functions such as cell division and motility[1-5]. Designing analogous…

Plasmodium of Physarym polycephalum is an ideal biological substrate for implementing concurrent and parallel computation, including combinatorial geometry and optimization on graphs. We report results of scoping experiments on Physarum…

In biological systems, molecular-scale forces and motions are pivotal for enabling processes like motility, shape change, and replication. These forces and motions are organized, amplified, and transmitted across macroscopic scales by…

We theoretically investigate the dynamics of a floating lipid bilayer membrane coupled with a two-dimensional cytoskeleton network, taking into explicitly account the intermonolayer friction, the discrete lattice structure of the…

The mechanical properties of a thin, planar material, perfused by an embedded flow network, can be changed locally and globally by the fluid transport and storage, resulting in small or large-scale deformation, such as out-of-plane…

In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long…

Many studies have shown that Physarum polycephalum slime mold is able to find the shortest path in a maze. In this paper we study this behavior in a network, using a hyperbolic model of chemotaxis. Suitable transmission and boundary…

Many cellular processes require a polarization axis which generally initially emerges as an inhomogeneous distribution of molecular markers in the cell. We present a simple analytical model of a general mechanism of cell polarization taking…

Acellular slime mould Physarum polycephalum is a monstrously large single cell visible by an unaided eye. It shows sophisticated behavioural traits in foraging for nutrients and developing an optimal transport network of protoplasmic tubes…

The observed spatio-temporal ciliary beat patterns on multiciliated epithelia are suspected to be the result of self-organizing processes on various levels. Here, we present an abstract epithelium model at the pluricellular level, which…

Motivated by recent experimental studies, we derive and analyze a twodimensional model for the contraction patterns observed in protoplasmic droplets of Physarum polycephalum. The model couples a model of an active poroelastic two-phase…

Belgium is amongst few artificial countries, established on purpose, when Dutch and French speaking parts were joined in a single unit. This makes Belgium a particularly interesting testbed for studying bio-inspired techniques for…

Turbulence plays a major role in shaping marine community structure as it affects organism dispersal and guides fundamental ecological interactions. Below oceanographic mesoscale dynamics, turbulence also impinges on subtle…

Mitochondrial networks exhibit a variety of complex behaviors, including coordinated cell-wide oscillations of energy states as well as a phase transition (depolarization) in response to oxidative stress. Since functional and structural…

Nowadays, multiscale modelling is recognized as the most suitable way to study biological processes. Indeed, almost every phenomenon in nature exhibits a multiscale behaviour, i.e., it is the outcome of interactions that occur at different…

Microorganism motility often takes place within complex, viscoelastic fluid environments, e.g., sperm in cervicovaginal mucus and bacteria in biofilms. In such complex fluids, strains and stresses generated by the microorganism are stored…

This paper presents an experimental investigation on pattern formation and evolution in bilayered tubular organs using swelling deformation of polydimethylsiloxane (PDMS) and aims at supplying a thorough comparison with theoretical and…

We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective…

Very simple organisms, such as the single-celled amoeboid slime mould Physarum polycephalum possess no neural tissue yet, despite this, are known to exhibit complex biological and computational behaviour. Given such limited resources, can…