相关论文: Nonclassical phase diagram for virus bacterial co-…
The dynamics of the spread of contagions such as viruses, infectious diseases or even rumors/opinions over contact networks (graphs) have effectively been captured by the well known \textit{Susceptible-Infected-Susceptible} ($SIS$) epidemic…
Species sharing a prey or a predator species may go extinct due to exploitative or apparent competition. We examine whether evolution of the shared species acts as a coexistence mechanism and to what extent the answer depends on the genetic…
Background. In a number of recent experiments with food-and-mouth disease virus, a deleterious mutant, was found to avoid extinction and remain in the population for long periods of time. This observation was called quasispecies memory. The…
The paper deals with the setting where two viruses (say virus 1 and virus 2) coexist in a population, and they are not necessarily mutually exclusive, in the sense that infection due to one virus does not preclude the possibility of…
We investigate the time evolution of an initial step profile separating a bare substrate region from the rest of the compressively strained adsorbate layer near a commensurate to incommensurate transition. The rate of profile evolution as a…
Compartmental models are the most widely used framework for modeling infectious diseases. These models have been continuously refined to incorporate all the realistic mechanisms that can shape the course of an epidemic outbreak. Building on…
Computer viruses have many similarities to biological viruses, and their association may offer new perspectives and new opportunities in the effort to tackle and even eradicate them. Evolutionary game theory has been established as a useful…
Proliferation and motility are ubiquitous drivers of activity in biological systems. Here, we study a dense binary mixture of motile and proliferating particles with exclusively repulsive interactions, where homeostasis in the proliferating…
A critical step in the bacteriophage life cycle is genome ejection into host bacteria. The ejection process for double-stranded DNA phages has been studied thoroughly \textit{in vitro}, where after triggering with the cellular receptor the…
In this work we have investigated the evolutionary dynamics of a generalist pathogen, e.g. a virus population, that evolves towards specialisation in an environment with multiple host types. We have particularly explored under which…
We consider a stochastic model for a pathogen population in the presence of an immune response, in which pathogen types are partially ordered by ancestry and the immune system must eliminate ancestor types before it can eliminate their…
The coexistence of different viral strains (quasispecies) within the same host are nowadays observed for a growing number of viruses, most notably HIV, Marburg and Ebola, but the conditions for the formation and survival of new strains have…
Aging is a fundamental aspect of living systems that undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. Living systems, known as complex systems, require complexity…
We demonstrate diversification rather than optimisation for highly interacting organisms in a well mixed biological system by means of a simple model and reference to experiment, and find the cause to be the complex network of interactions…
CRISPR technology has enabled large-scale cell lineage tracing for complex multicellular organisms by mutating synthetic genomic barcodes during organismal development. However, these sophisticated biological tools currently use ad-hoc and…
We consider the diffusion approximation of branching processes in random environment (BPREs). This diffusion approximation is similar to and mathematically more tractable than BPREs. We obtain the exact asymptotic behavior of the survival…
Disease outbreaks affect many ecosystems threatening species that also fight against other natural enemies. We investigate a cyclic game system with $5$ species, whose organisms outcompete according to the rules of a generalised spatial…
Inferring dependencies between complex biological traits while accounting for evolutionary relationships between specimens is of great scientific interest yet remains infeasible when trait and specimen counts grow large. The…
Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells.…
We analyze the Susceptible-Infected-Recovered-Susceptible (SIRS) process, a continuous-time Markov chain frequently employed in epidemiology to model the spread of infections on networks. In this framework, infections spread as infected…