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Chemical equilibrium is fully characterized by thermodynamics, while the rates of chemical reactions can be calculated for ideal solutions by using mass-action equations. The evaluation of the rates of reactions in a non-ideal system is…

化学物理 · 物理学 2025-01-20 Doriano Brogioli , Fabio La Mantia

Chemically accurate and comprehensive studies of the virtual space of all possible molecules are severely limited by the computational cost of quantum chemistry. We introduce a composite strategy that adds machine learning corrections to…

Model-based process simulation can be used to derive designs and operating conditions of chemical processes that optimally balance multiple objectives, such as quality, costs, or environmental impacts. This work focuses on identifying…

Estimating reaction rates and chemical stability is fundamental, yet efficient methods for large-scale simulations remain out of reach despite advances in modeling and exascale computing. Direct simulation is limited by short timescales;…

化学物理 · 物理学 2025-12-15 Rohit Goswami

Predicting monomer reactivity ratios is crucial for controlling monomer sequence distribution in copolymers and their properties. Traditional experimental methods of determining reactivity ratios are time-consuming and resource-intensive,…

化学物理 · 物理学 2025-12-24 Habibollah Safari , Mona Bavarian

Accurately modeling chemical reactions at the atomistic level requires high-level electronic structure theory due to the presence of unpaired electrons and the need to properly describe bond breaking and making energetics. Commonly used…

Computational quantum mechanics based molecular and materials design campaigns consume increasingly more high-performance compute resources, making improved job scheduling efficiency desirable in order to reduce carbon footprint or wasteful…

化学物理 · 物理学 2020-06-15 Stefan Heinen , Max Schwilk , Guido Falk von Rudorff , O. Anatole von Lilienfeld

Optimal operation of chemical processes is vital for energy, resource, and cost savings in chemical engineering. The problem of optimal operation can be tackled with reinforcement learning, but traditional reinforcement learning methods…

机器学习 · 计算机科学 2025-11-21 Dean Brandner , Sergio Lucia

Recent progress in machine learning has sparked increased interest in utilizing this technology to predict the outcomes of chemical reactions. The ultimate aim of such endeavors is to develop a universal model that can predict products for…

化学物理 · 物理学 2025-07-03 Daniel Julian , Jesús Pérez-Ríos

The use of reinforcement learning (RL) in scientific applications, such as materials design and automated chemistry, is increasing. A major challenge, however, lies in fact that measuring the state of the system is often costly and time…

机器学习 · 计算机科学 2022-04-08 Colin Bellinger , Andriy Drozdyuk , Mark Crowley , Isaac Tamblyn

Theoretical studies on chemical reaction mechanisms have been crucial in organic chemistry. Traditionally, calculating the manually constructed molecular conformations of transition states for chemical reactions using quantum chemical…

化学物理 · 物理学 2024-04-12 Sihao Yuan , Xu Han , Jun Zhang , Zhaoxin Xie , Cheng Fan , Yunlong Xiao , Yi Qin Gao , Yi Isaac Yang

A common workflow for many engineering design problems requires the evaluation of the design system to be investigated under a range of conditions. These conditions usually involve a combination of several parameters. To perform a complete…

计算工程、金融与科学 · 计算机科学 2020-09-18 J. H. Gaspar Elsas , N. A. G. Casaprima , I. F. M. Menezes

A novel approach is presented for the solution of instantaneous chemical equilibrium problems. The chemical equilibrium can be considered, due to its intrinsically local character, as a mapping of the three-dimensional parameter space…

天体物理学 · 物理学 2009-11-11 A. Asensio Ramos , H. Socas-Navarro

Calculating free energy differences is a topic of substantial interest and has many applications including molecular docking and hydration, solvation, and binding free energies which is used in computational drug discovery. However, in…

化学物理 · 物理学 2013-10-16 Asaf Farhi

A variety of natural phenomena comprises a huge number of competing reactions and short-lived intermediates. Any study of such processes requires the discovery and accurate modeling of their underlying reaction network. However, this task…

化学物理 · 物理学 2014-05-27 Paolo Elvati , Angela Violi

Computer-assisted synthesis planning aims to help chemists find better reaction pathways faster. Finding viable and short pathways from sugar molecules to value-added chemicals can be modeled as a retrosynthesis planning problem with a…

其他计算机科学 · 计算机科学 2019-11-19 Peihong Jiang , Hieu Doan , Sandeep Madireddy , Rajeev Surendran Assary , Prasanna Balaprakash

Large-scale electrification is vital to addressing the climate crisis, but several scientific and technological challenges remain to fully electrify both the chemical industry and transportation. In both of these areas, new electrochemical…

We present a machine learning based approach to address the study of transport processes, ubiquitous in continuous mechanics, with particular attention to those phenomena ruled by complex micro-physics, impractical to theoretical…

等离子体物理 · 物理学 2022-06-16 Francesco Miniati , Gianluca Gregori

Complex planning and scheduling problems have long been solved using various optimization or heuristic approaches. In recent years, imitation learning that aims to learn from expert demonstrations has been proposed as a viable alternative…

机器学习 · 计算机科学 2024-05-24 Qian Shao , Pradeep Varakantham , Shih-Fen Cheng

Recent advances in random-walk particle-tracking have enabled direct simulation of mixing and reactions on particles by allowing the particles to interact with each other using a multi-point mass transfer scheme. The mass transfer scheme…

计算物理 · 物理学 2019-04-22 Nicholas B. Engdahl , Michael J. Schmidt , David A. Benson