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In genome-wide epigenetic studies, exposures (e.g., Single Nucleotide Polymorphisms) affect outcomes (e.g., gene expression) through intermediate variables such as DNA methylation. Mediation analysis offers a way to study these intermediate…

统计方法学 · 统计学 2025-12-08 Asmita Roy , Xianyang Zhang

Consider the multiple testing problem of testing null hypotheses $H_1,...,H_s$. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($\mathit{FWER}$),…

统计理论 · 数学 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

We address modelling and computational issues for multiple treatment effect inference under many potential confounders. Our main contribution is providing a trade-off between preventing the omission of relevant confounders, while not…

统计方法学 · 统计学 2025-02-04 Omiros Papaspiliopoulos , David Rossell , Miquel Torrens-i-Dinarès

In hypothesis testing, a false discovery occurs when a hypothesis is incorrectly rejected due to noise in the sample. When adaptively testing multiple hypotheses, the probability of a false discovery increases as more tests are performed.…

机器学习 · 统计学 2020-10-22 Wanrong Zhang , Gautam Kamath , Rachel Cummings

Many-Objective Feature Selection (MOFS) approaches use four or more objectives to determine the relevance of a subset of features in a supervised learning task. As a consequence, MOFS typically returns a large set of non-dominated…

机器学习 · 计算机科学 2023-12-01 Uchechukwu F. Njoku , Alberto Abelló , Besim Bilalli , Gianluca Bontempi

Recent large cancer studies have measured somatic alterations in an unprecedented number of tumours. These large datasets allow the identification of cancer-related sets of genetic alterations by identifying relevant combinatorial patterns.…

定量方法 · 定量生物学 2019-06-19 Rebecca Sarto Basso , Dorit S. Hochbaum , Fabio Vandin

The highly influential two-group model in testing a large number of statistical hypotheses assumes that the test statistics are drawn independently from a mixture of a high probability null distribution and a low probability alternative.…

统计方法学 · 统计学 2020-12-08 Ruth Heller , Saharon Rosset

The unscented Kalman filter (UKF) is a commonly used algorithm capable of estimating the states of nonlinear dynamic systems. It carefully chooses a set of sample points, called sigma points that capture the nonlinear system states…

信号处理 · 电气工程与系统科学 2026-04-07 Amit Levy , Itzik Klein

Using brain imaging quantitative traits (QTs) to identify the genetic risk factors is an important research topic in imaging genetics. Many efforts have been made via building linear models, e.g. linear regression (LR), to extract the…

Traditional recommender systems aim to estimate a user's rating to an item based on observed ratings from the population. As with all observational studies, hidden confounders, which are factors that affect both item exposures and user…

机器学习 · 计算机科学 2022-11-22 Yaochen Zhu , Jing Yi , Jiayi Xie , Zhenzhong Chen

In probability theory, the partition function is a factor used to reduce any probability function to a density function with total probability of one. Among other statistical models used to represent joint distribution, Markov random fields…

新兴技术 · 计算机科学 2025-01-03 Timothe Presles , Cyrille Enderli , Gilles Burel , El Houssain Baghious

Stochastic Closed-Loop Active Fault Diagnosis (CLAFD) aims to select the input sequentially in order to improve the discrimination of different models by minimizing the predicted error probability. As computation of these error…

系统与控制 · 电气工程与系统科学 2024-01-12 Jacques Noom , Oleg Soloviev , Carlas Smith , Michel Verhaegen

Markov random fields (MRFs) are invaluable tools across diverse fields, and spatiotemporal MRFs (STMRFs) amplify their effectiveness by integrating spatial and temporal dimensions. However, modeling spatiotemporal data introduces additional…

统计方法学 · 统计学 2024-04-30 Ning Ning

Kernel Adaptive Filtering (KAF) are mathematically principled methods which search for a function in a Reproducing Kernel Hilbert Space. While they work well for tasks such as time series prediction and system identification they are…

机器学习 · 计算机科学 2023-12-20 Benjamin Colburn , Jose C. Principe , Luis G. Sanchez Giraldo

Many important tasks of large-scale recommender systems can be naturally cast as testing multiple linear forms for noisy matrix completion. These problems, however, present unique challenges because of the subtle bias-and-variance tradeoff…

统计方法学 · 统计学 2025-03-12 Wanteng Ma , Lilun Du , Dong Xia , Ming Yuan

Control barrier functions (CBFs) have been widely used for synthesizing controllers in safety-critical applications. When used as a safety filter, it provides a simple and computationally efficient way to obtain safe controls from a…

系统与控制 · 电气工程与系统科学 2023-03-13 Bolun Dai , Heming Huang , Prashanth Krishnamurthy , Farshad Khorrami

The complex systems with edge computing require a huge amount of multi-feature data to extract appropriate insights for their decision making, so it is important to find a feasible feature selection method to improve the computational…

机器学习 · 计算机科学 2024-05-14 Wenjie Liu , Junxiu Chen , Yuxiang Wang , Peipei Gao , Zhibin Lei , Xu Ma

Multiple hypothesis testing is a central topic in statistics, but despite abundant work on the false discovery rate (FDR) and the corresponding Type-II error concept known as the false non-discovery rate (FNR), a fine-grained understanding…

统计理论 · 数学 2017-05-17 Maxim Rabinovich , Aaditya Ramdas , Michael I. Jordan , Martin J. Wainwright

Multi-frame algorithms for single-channel speech enhancement are able to take advantage from short-time correlations within the speech signal. Deep filtering (DF) recently demonstrated its capabilities for low-latency scenarios like hearing…

音频与语音处理 · 电气工程与系统科学 2023-05-16 Hendrik Schröter , Tobias Rosenkranz , Alberto N. Escalante-B. , Andreas Maier

Variable selection has played a critical role in modern statistical learning and scientific discoveries. Numerous regularization and Bayesian variable selection methods have been developed in the past two decades for variable selection, but…

统计方法学 · 统计学 2024-03-04 Travis Canida , Hongjie Ke , Shuo Chen , Zhenayo Ye , Tianzhou Ma
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