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Through genome-wide association studies (GWAS), disease susceptible genetic variables can be identified by comparing the genetic data of individuals with and without a specific disease. However, the discovery of these associations poses a…

机器学习 · 计算机科学 2023-08-15 Zhendong Sha , Yuanzhu Chen , Ting Hu

Affordable, high-quality whole-genome assemblies have made it possible to construct rich pangenomes that capture haplotype diversity across many species. As these datasets grow, they motivate the development of specialized techniques…

基因组学 · 定量生物学 2025-12-19 Gorkem Kadir Solun , Ugur Dogrusoz

Genetic algorithms, computer programs that simulate natural evolution, are increasingly applied across many disciplines. They have been used to solve various optimisation problems from neural network architecture search to strategic games,…

神经与进化计算 · 计算机科学 2021-09-14 Aymeric Vie , Alissa M. Kleinnijenhuis , Doyne J. Farmer

Correlation Plenoptic Imaging (CPI) is a novel technological imaging modality enabling to overcome drawbacks of standard plenoptic devices, while preserving their advantages. However, a major challenge in view of real-time application of…

During genomics life science research, the data volume of whole genomics and life science algorithm is going bigger and bigger, which is calculated as TB, PB or EB etc. The key problem will be how to store and analyze the data with…

数据库 · 计算机科学 2017-02-01 Hao Li

In this work, we present an extension of Gaussian process (GP) models with sophisticated parallelization and GPU acceleration. The parallelization scheme arises naturally from the modular computational structure w.r.t. datapoints in the…

分布式、并行与集群计算 · 计算机科学 2014-10-21 Zhenwen Dai , Andreas Damianou , James Hensman , Neil Lawrence

Approximate Nearest Neighbor Search (ANNS) underpins many large-scale data mining and machine learning applications, with efficient retrieval increasingly hinging on GPU acceleration as dataset sizes grow. Although graph-based approaches…

In this paper, we study the problem of graph similarity search with graph edit distance (GED) constraints. Due to the NP-hardness of GED computation, existing solutions to this problem adopt the filtering-and-verification framework with a…

数据库 · 计算机科学 2020-04-03 Jongik Kim

Support Vector Machines (SVM), a popular machine learning technique, has been applied to a wide range of domains such as science, finance, and social networks for supervised learning. Whether it is identifying high-risk patients by…

分布式、并行与集群计算 · 计算机科学 2014-06-20 Jeyanthi Narasimhan , Abhinav Vishnu , Lawrence Holder , Adolfy Hoisie

The introduction of accelerator devices such as graphics processing units (GPUs) has had profound impact on molecular dynamics simulations and has enabled order-of-magnitude performance advances using commodity hardware. To fully reap these…

There have been extensive works dealing with genetic algorithms (GAs) for seeking optimal solutions of shop scheduling problems. Due to the NP hardness, the time cost is always heavy. With the development of high performance computing (HPC)…

分布式、并行与集群计算 · 计算机科学 2019-04-09 Jia Luo , Didier El Baz

Approximate Nearest Neighbor Search (ANNS) has become fundamental to modern deep learning applications, having gained particular prominence through its integration into recent generative models that work with increasingly complex datasets…

分布式、并行与集群计算 · 计算机科学 2025-03-28 Yuntao Gui , Peiqi Yin , Xiao Yan , Chaorui Zhang , Weixi Zhang , James Cheng

AI accelerator processing capabilities and memory constraints largely dictate the scale in which machine learning workloads (e.g., training and inference) can be executed within a desirable time frame. Training a state of the art,…

分布式、并行与集群计算 · 计算机科学 2023-10-12 Michael Benington , Leo Phan , Chris Pierre Paul , Evan Shoemaker , Priyanka Ranade , Torstein Collett , Grant Hodgson Perez , Christopher Krieger

The computation of distance measures between nodes in graphs is inefficient and does not scale to large graphs. We explore dense vector representations as an effective way to approximate the same information: we introduce a simple yet…

计算与语言 · 计算机科学 2019-06-18 Andrey Kutuzov , Mohammad Dorgham , Oleksiy Oliynyk , Chris Biemann , Alexander Panchenko

We present EvoSort, a general-purpose adaptive parallel parallel sorting framework accessible at the Python level. EvoSort employs a Genetic Algorithm (GA) to automatically discover and refine critical parameters, including insertion sort…

分布式、并行与集群计算 · 计算机科学 2026-01-05 Shashank Raj , Kalyanmoy Deb

Genome-wide association studies generate very large datasets that require scalable analysis algorithms. In this report we describe the GEDI software package, which implements efficient algorithms for performing several common tasks in the…

数据结构与算法 · 计算机科学 2016-09-08 Justin Kennedy , Ion I. Mandoiu , Bogdan Pasaniuc

Since the emergence of genome-wide association studies (GWASs), estimation of the narrow sense heritability explained by common single-nucleotide polymorphisms (SNPs) via linear mixed model approaches became widely used. As in most GWASs,…

统计方法学 · 统计学 2015-07-31 Najla Saad Elhezzani

We develop methods for accelerating metric similarity search that are effective on modern hardware. Our algorithms factor into easily parallelizable components, making them simple to deploy and efficient on multicore CPUs and GPUs. Despite…

数据库 · 计算机科学 2016-11-15 Lawrence Cayton

The identification of disease-associated genes has recently gathered much attention for uncovering disease complex mechanisms that could lead to new insights into the treatment of diseases. For exploring disease-susceptible genes, not only…

计算工程、金融与科学 · 计算机科学 2016-04-27 Zahra Razaghi-Moghadam , Razieh Abdollahi , Sama Goliaei , Morteza Ebrahimi

The exponential growth of DNA sequencing data has outpaced traditional heuristic-based methods, which struggle to scale effectively. Efficient computational approaches are urgently needed to support large-scale similarity search, a…