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Single-cell RNA sequencing (scRNA-seq), especially temporally resolved datasets, enables genome-wide profiling of gene expression dynamics at single-cell resolution across discrete time points. However, current technologies provide only…

基因组学 · 定量生物学 2025-11-19 Yue Ling , Peiqi Zhang , Zhenyi Zhang , Peijie Zhou

Segmentation is a fundamental process in microscopic cell image analysis. With the advent of recent advances in deep learning, more accurate and high-throughput cell segmentation has become feasible. However, most existing deep…

计算机视觉与模式识别 · 计算机科学 2020-06-25 Hyeonsoo Lee , Won-Ki Jeong

We share our recent findings in an attempt to train a universal segmentation network for various cell types and imaging modalities. Our method was built on the generalized U-Net architecture, which allows the evaluation of each component…

计算机视觉与模式识别 · 计算机科学 2022-08-01 Tianqi Guo , Yin Wang , Luis Solorio , Jan P. Allebach

Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for…

定量方法 · 定量生物学 2025-08-26 Surajit Das , Gourav Roy , Pavel Zun

Segmentation, or the outlining of objects within images, is a critical step in the measurement and analysis of cells within microscopy images. While improvements continue to be made in tools that rely on classical methods for segmentation,…

定量方法 · 定量生物学 2024-03-15 Nodar Gogoberidze , Beth A. Cimini

Epigenetic Tracking is a mathematical model of biological cells, originally conceived to study embryonic development. Computer simulations proved the capacity of the model to generate complex 3-dimensional cellular structures, and the…

细胞行为 · 定量生物学 2015-07-07 Alessandro Fontana

Every year millions of people die due to disease of Cancer. Due to its invasive nature it is very complex to cure even in primary stages. Hence, only method to survive this disease completely is via forecasting by analyzing the early…

计算机视觉与模式识别 · 计算机科学 2018-08-24 Shivam Singh , Stuti Pathak

Recently, action proposal methods have played an important role in action recognition tasks, as they reduce the search space dramatically. Most unsupervised action proposal methods tend to generate hundreds of action proposals which include…

计算机视觉与模式识别 · 计算机科学 2017-04-05 Waqas Sultani , Dong Zhang , Mubarak Shah

Imaging assays of cellular function, especially those using fluorescent stains, are ubiquitous in the biological and medical sciences. Despite advances in computer vision, such images are often analyzed using only manual or rudimentary…

计算机视觉与模式识别 · 计算机科学 2017-06-06 Lena R. Bartell , Lawrence J. Bonassar , Itai Cohen

3D microscopy is key in the investigation of diverse biological systems, and the ever increasing availability of large datasets demands automatic cell identification methods that not only are accurate, but also can imply the uncertainty in…

计算机视觉与模式识别 · 计算机科学 2021-02-24 Alvaro Gomariz , Tiziano Portenier , César Nombela-Arrieta , Orcun Goksel

Cell segmentation for multi-modal microscopy images remains a challenge due to the complex textures, patterns, and cell shapes in these images. To tackle the problem, we first develop an automatic cell classification pipeline to label the…

计算机视觉与模式识别 · 计算机科学 2023-10-24 Wei Lou , Xinyi Yu , Chenyu Liu , Xiang Wan , Guanbin Li , Siqi Liu , Haofeng Li

We propose a weakly-supervised cell tracking method that can train a convolutional neural network (CNN) by using only the annotation of "cell detection" (i.e., the coordinates of cell positions) without association information, in which…

计算机视觉与模式识别 · 计算机科学 2020-07-31 Kazuya Nishimura , Junya Hayashida , Chenyang Wang , Dai Fei Elmer Ker , Ryoma Bise

We introduce CellSegmenter, a structured deep generative model and an amortized inference framework for unsupervised representation learning and instance segmentation tasks. The proposed inference algorithm is convolutional and…

计算机视觉与模式识别 · 计算机科学 2020-11-26 Luca D'Alessio , Mehrtash Babadi

In the effort to aid cytologic diagnostics by establishing automatic single cell screening using high throughput digital holographic microscopy for clinical studies thousands of images and millions of cells are captured. The bottleneck lies…

图像与视频处理 · 电气工程与系统科学 2024-10-28 Julia Sistermanns , Ellen Emken , Gregor Weirich , Oliver Hayden , Wolfgang Utschick

Microscopy images contain rich information about how cells respond to perturbations, making them essential to applications like drug screening. To quantify images, researchers often use representation extraction methods, and recent years…

计算机视觉与模式识别 · 计算机科学 2026-05-18 Emre Hayir , Lorin Crawford , Alex X. Lu

Accurately counting the number of cells in microscopy images is required in many medical diagnosis and biological studies. This task is tedious, time-consuming, and prone to subjective errors. However, designing automatic counting methods…

图像与视频处理 · 电气工程与系统科学 2020-11-11 Shenghua He , Kyaw Thu Minn , Lilianna Solnica-Krezel , Mark A. Anastasio , Hua Li

Classifying and analyzing human cells is a lengthy procedure, often involving a trained professional. In an attempt to expedite this process, an active area of research involves automating cell classification through use of deep…

计算机视觉与模式识别 · 计算机科学 2022-03-15 Reece Walsh , Mohamed H. Abdelpakey , Mohamed S. Shehata , Mostafa M. Mohamed

We contribute a deep-learning-based method that assists in designing analytical dashboards for analyzing a data table. Given a data table, data workers usually need to experience a tedious and time-consuming process to select meaningful…

人机交互 · 计算机科学 2021-07-19 Aoyu Wu , Yun Wang , Mengyu Zhou , Xinyi He , Haidong Zhang , Huamin Qu , Dongmei Zhang

In many multiobject tracking applications, including radar and sonar tracking, after prefiltering the received signal, measurement data is typically structured in cells. The cells, e.g., represent different range and bearing values.…

信号处理 · 电气工程与系统科学 2024-06-04 Thomas Kropfreiter , Jason L. Williams , Florian Meyer

The spatio-temporal nature of live-cell microscopy data poses challenges in the analysis of cell states which is fundamental in bioimaging. Deep-learning based segmentation or tracking methods rely on large amount of high quality…

计算机视觉与模式识别 · 计算机科学 2024-11-12 Cangxiong Chen , Vinay P. Namboodiri , Julia E. Sero