相关论文: GlnK facilitates the dynamic regulation of bacteri…
It is natural to ask how bacteria coordinate metabolism when depletion of an essential nutrient limits their growth, and they must slow their entire rate of biosynthesis. A major nutrient with a fluctuating abundance is nitrogen. The growth…
The genetic regulatory network (GRN) plays a key role in controlling the response of the cell to changes in the environment. Although the structure of GRNs has been the subject of many studies, their large scale structure in the light of…
The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in response to the…
The E. coli glucose-galactose chemosensory receptor is a 309 residue, 32 kDa protein consisting of two distinct structural domains. In this computational study, we studied the protein's thermal fluctuations, including both the large scale…
The Gene Regulatory Network (GRN) of biological cells governs a number of key functionalities that enables them to adapt and survive through different environmental conditions. Close observation of the GRN shows that the structure and…
Active galactic nuclei (AGN) are accreting supermassive black holes co-evolving with their host galaxies through a complex interplay of feeding and feedback. In this chapter, we first discuss AGN fuelling in galaxies, both in interacting…
Dynamical mechanisms are essential to exchange angular momentum in galaxies, drive the gas to the center, and fuel the central super-massive black holes. While at 100pc scale, the gas is sometimes stalled in nuclear rings, recent…
Dual active galactic nuclei (AGN) offer a unique opportunity to probe the relationship between super massive black holes (SMBH) and their host galaxies as well as the role of major mergers in triggering AGN activity. The confirmed dual AGN…
A combination of Fourier transform infrared and phase transition measurements as well as molecular computer simulations, and thermodynamic modeling were performed to probe the mechanisms by which guanidinium salts influence the stability of…
The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations in order to maintain a proper energy balance in cells. We show here that suckling-weaning and…
Understanding the link between structure and function in proteins is fundamental in molecular biology and proteomics. A central question in this context is whether allostery - where the binding of a molecule at one site affects the activity…
To sustain metabolism, intracellular ATP concentration must be regulated within an appropriate range. This coordination is achieved through the function of the AMP-activated protein kinase (AMPK), a cellular "fuel gauge" that is expressed…
An amphiphilic nature of the surfactant-like peptides is responsible for their propensity to aggregate at the nanoscale. These peptides can be readily used for a non-covalent functionalization of nanoparticles and macromolecules. This work…
Recently, there has been a lot of effort in understanding sRNA mediated regulation of gene expression and how this mode of regulation differs from transcriptional regulation.In E.coli, in the presence of oxidative stress, the synthesis of…
Gene regulatory networks (GRN) govern phenotypic adaptations and reflect the trade-offs between physiological responses and evolutionary adaptation that act at different time scales. To identify patterns of molecular function and genetic…
In order to understand the physical mechanisms at work during the formation of massive early-type galaxies, we performed six zoomed hydrodynamical cosmological simulations of halos in the mass range 4.3 10^12 < M_vir < 8.0 10^13 M_sun at…
The accurate prediction of physicochemical properties of chemical compounds in mixtures (such as the activity coefficient at infinite dilution $\gamma_{ij}^\infty$) is essential for developing novel and more sustainable chemical processes.…
Why sex is maintained in nature is a fundamental question in biology. Natural genetic transformation (NGT) is a sexual process by which bacteria actively take up exogenous DNA and use it to replace homologous chromosomal sequences. As it…
Grokking - the delayed transition from memorisation to generalisation in neural networks - remains poorly understood. We study this phenomenon through the geometry of learned representations and identify a consistent empirical signature…
A popular self--enrichment scenario for the formation of globular clusters assumes that the abundance anomalies shown by the stars in many clusters are due to a second stage of star formation occurring from the matter lost by the winds of…