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Our sense of smell relies on sensitive, selective atomic-scale processes that are initiated when a scent molecule meets specific receptors in the nose. However, the physical mechanisms of detection are not clear. While odorant shape and…

生物物理 · 物理学 2015-06-26 Jennifer C. Brookes , Filio Hartoutsiou , A. P. Horsfield , A. M. Stoneham

The mechanism by which odorants are recognized by olfactory receptors remains primarily unresolved. While charge transport is believed to play a significant role, its precise nature is still unclear. Here, we present a novel perspective by…

化学物理 · 物理学 2025-06-30 Dominik Szczȩśniak , Ewa Drzazga-Szczȩśniak , Sabre Kais

The vibrational theory of olfaction was posited to explain subtle effects in the sense of smell inexplicable by models in which molecular structure alone determines an odorant's smell. Amazingly, behavioral and neurophysiological evidence…

生物物理 · 物理学 2019-05-01 Nishattasnim Liza , Enrique P. Blair

Inelastic electron transfer being regarded as one of the potential mechanisms to explain the odorant recognition in the atomic-scale processes is still a matter of intense debate. Here, we propose multiphonon processes of electrons transfer…

生物物理 · 物理学 2021-08-02 Shu-Quan Zhang , Yu Cui , Xue-Wei Li , Yong Sun , Zi-Wu Wang

Motivated by a proposed olfactory mechanism based on a vibrationally-activated molecular switch, we study electron transport within a donor-acceptor pair that is coupled to a vibrational mode and embedded in a surrounding environment. We…

介观与纳米尺度物理 · 物理学 2015-02-12 Agata Checinska , Felix A. Pollock , Libby Heaney , Ahsan Nazir

The standard model for molecular recognition of an odorant is that receptor sites discriminate by molecular geometry as evidenced that two chiral molecules may smell very differently. However, recent studies of isotopically labeled…

生物物理 · 物理学 2015-06-05 Eric R. Bittner , Adrian Madalan , Arkadiuz Czader , Gregg Roman

Odor-based Molecular Communication (OMC) employs odor molecules to convey information, contributing to the realization of the Internet of Everything (IoE) vision. Despite this, the practical deployment of OMC systems is currently limited by…

信号处理 · 电气工程与系统科学 2026-02-03 Ahmet B. Kilic , Fatih E. Bilgen , Ozgur B. Akan

The sense of smell is an important part of living organisms. It assists with the interaction of the living organism with its environment. The mechanism by which smell is detected and identified is not fully known. Earlier, shape theory was…

生物物理 · 物理学 2019-11-07 Chukwuemeka Asogwa

We introduce and study an artificial neural network, inspired by the probabilistic Receptor Affinity Distribution model of olfaction. Our system consists on N sensory neurons whose outputs converge on a single processing linear threshold…

无序系统与神经网络 · 物理学 2007-05-23 N. Caticha , J. E. Palo Tejada , D. Lancet , E. Domany

In this work we consider the question of whether a simple diffusive model can explain the scent tracking behaviours found in nature. For this behaviour to occur, both the concentration of a scent and its gradient must be above some…

软凝聚态物质 · 物理学 2021-03-31 Gerard McCaul , Andreas Mershin , Denys I. Bondar

Odor detection underpins food safety, environmental monitoring, medical diagnostics, and many more fields. The current artificial sensors developed for odor detection struggle with complex mixtures while non-invasive recordings lack…

机器学习 · 计算机科学 2025-08-14 Matin Hassanloo , Ali Zareh , Mehmet Kemal Özdemir

Neuromorphic computing is one of the few current approaches that have the potential to significantly reduce power consumption in Machine Learning and Artificial Intelligence. Imam & Cleland presented an odour-learning algorithm that runs on…

神经与进化计算 · 计算机科学 2023-09-22 Nik Dennler , André van Schaik , Michael Schmuker

We present a model of a coupled system of the olfactory bulb and cortex. Odor inputs to the epithelium are transformed to oscillatory bulbar activities. The cortex recognizes the odor by resonating to the bulbar oscillating pattern when the…

生物物理 · 物理学 2007-05-23 Zhaoping Li , John Hertz

Olfactory systems use a small number of broadly sensitive receptors to combinatorially encode a vast number of odors. We propose a method of decoding such distributed representations by exploiting a statistical fact: receptors that do not…

神经元与认知 · 定量生物学 2021-09-01 Vijay Singh , Martin Tchernookov , Vijay Balasubramanian

We present a model of an olfactory system that performs odor segmentation. Based on the anatomy and physiology of natural olfactory systems, it consists of a pair of coupled modules, bulb and cortex. The bulb encodes the odor inputs as…

无序系统与神经网络 · 物理学 2007-05-23 Zhaoping Li , John Hertz

Predicting olfactory perception directly from molecular structure is central to fragrance design that plays a role in a wide range of industries, such as perfumery, food and beverage, and health care. Among olfactory attributes, odor…

化学物理 · 物理学 2026-05-18 Peter Fichtelmann , Julia Westermayr

We present a generalized theoretical framework for olfactory representation and plasticity, using the theory of smooth manifolds and sheaves to depict categorical odor learning via distributed neural computation. Beginning with the space of…

神经元与认知 · 定量生物学 2023-10-13 Jack A. Cook , Thomas A. Cleland

We present a model of dissipative transport in the fractional quantum Hall regime. Our model takes account of tunneling through saddle points in the effective potential for excitations created by impurities. We predict the temperature range…

介观与纳米尺度物理 · 物理学 2011-03-28 N. d'Ambrumenil , B. I. Halperin , R. H. Morf

The olfactory system is constantly solving pattern-recognition problems by the creation of a large space to codify odour representations and optimizing their distribution within it. A model of the Olfactory Bulb was developed by Z. Li and…

适应与自组织系统 · 物理学 2019-05-16 Alexandra Pinto

Understanding how molecular structure gives rise to odor perception remains a long-standing challenge, with ongoing debate over whether olfaction is primarily governed by molecular shape, vibrational properties, or their interplay at the…

材料科学 · 物理学 2026-04-14 P. Zanineli , E. V. C. Lopes , G. R. Schleder , L. N. Lemos , F. Crasto de Lima , A. Fazzio
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